Published in Cellular Physiology and Biochemistry
Background/Aims: Osteoarthritis (OA) is a joint degenerative biomechanical disorder involving immunity, metabolic alterations, inflammation, and cartilage degradation, where chondrocytes play a pivotal role. OA has not effective pharmacological treatments and new therapeutic targets are needed. Adipokines contribute to the low-grade systemic inflam...
Published in Pharmacology
Remifentanil-induced hyperalgesia (RIH) is known to be associated with oxidative stress and inflammation. Betulinic acid (BA) was reported to reduce visceral pain owing to its anti-oxidative and anti-inflammatory potential. Here, we explored whether BA can attenuate RIH through inhibiting oxidative stress and inflammation in spinal dorsal horn. Sp...
Published in Biomolecular Concepts
Members of the small heat shock protein (sHSP) family are molecular chaperones with a critical role in the maintenance of cellular homeostasis under unfavorable conditions. The chaperone properties of sHSPs prevent protein aggregation, and sHSP deregulation underlies the pathology of several diseases, including neurodegenerative disorders. Recent e...
Excessive consumption of lipids in the diet is a problem in the feeding of current society, contributing to the development of diseases and cancers such as breast, prostate and colon. Lipids can have direct action on the prostate gland, or by cellular mediators derived from them and unbalance levels of sexual steroids. However, some dietary compone...
Published in Pathobiology
Objective: β-Aminoisobutyric acid (BAIBA), a myokine, is a thymine catabolite that is induced during exercise, leading to browning of white fat, hepatic fatty acid oxidation, and suppression of hepatic lipogenesis. However, the effects of BAIBA on the progression of atherosclerosis remain unclear. Methods: We performed a Western blot analyses to de...
Published in Biochemical and biophysical research communications
Accumulating evidence indicates that a number of tissues are damaged due to build-up of abnormal amount of Advanced Glycation End products (AGEs) in several diseases including diabetes. Currently AGE inhibitors are scarce in clinical use indicating a need for development of new anti-AGE agents. The aim of the current study is to identify the new AG...
Raw data sets and example images used in publication
Published in Neuropsychobiology
Background: Immune dysregulation has been hypothesized to be important in the development and pathophysiology of compulsive disorders such as obsessive compulsive disorder (OCD), which has a high comorbid overlap with trichotillomania (both are OC-related disorders). The role of inflammation in the pathophysiology of trichotillomania has garnered l...
ABSTRACT Researches has been conducted to investigate the relationship between chronic inflammation in the oral cavity and deleterious effects on various systems of the body. Periodontal disease (PD) characterized as an infection and oral inflammation is associated with the production of inflammatory cytokines, such as tumor necrosis factor-alpha (...
The research leading to these results received funding from the European Union Seventh Framework Programme [FP7–2007-2013] under grant agreement number HEALTH-F4–2011-281608 (TIMER), from the São Paulo Research Foundation (FAPESP) under grant agreements number 2011/19670–0 (Projeto Temático) and 2013/08216–2 (Center for Research in Inflammatory Fig...
