Dioh, W. Chabane, M. Tourette, C. Azbekyan, A. Morelot-Panzini, C. Hajjar, L. A. Lins, M. Nair, G. B. Whitehouse, T. Mariani, J.
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Published in
Trials
ObjectivesAs of December, 1st, 2020, coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2, resulted in more than 1 472 917 deaths worldwide and death toll is still increasing exponentially. Many COVID-19 infected people are asymptomatic or experience moderate symptoms and recover without medical intervention. However, older people and those wit...
Kizilay Mancini, Ozge Huynh, David N Menard, Liliane Shum-Tim, Dominique Ong, Huy Marleau, Sylvie Colmegna, Ines Servant, Marc J
Published in
Cardiovascular research
Diabetes is a conventional risk factor for atherosclerotic cardiovascular disease and myocardial infarction (MI) is the most common cause of death among these patients. Mesenchymal stromal cells (MSCs) in patients with type 2 diabetes mellitus (T2DM) and atherosclerosis have impaired ability to suppress activated T-cells (i.e. reduced immunopotency...
Cooper, Hannah A Cicalese, Stephanie Preston, Kyle J Kawai, Tatsuo Okuno, Keisuke Choi, Eric T Kasahara, Shingo Uchida, Haruhito A Otaka, Nozomu Scalia, Rosario
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Published in
Cardiovascular research
Angiotensin II (AngII) is a potential contributor to the development of abdominal aortic aneurysm (AAA). In aortic vascular smooth muscle cells (VSMCs), exposure to AngII induces mitochondrial fission via dynamin-related protein 1 (Drp1). However, pathophysiological relevance of mitochondrial morphology in AngII-associated AAA remains unexplored. H...
Li, Yutian Deng, Shan Wang, Xiaohong Huang, Wei Chen, Jing Robbins, Nathan Mu, Xingjiang Essandoh, Kobina Peng, Tianqing Jegga, Anil G
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Published in
Cardiovascular research
Cardiac dysfunction is a prevalent comorbidity of disrupted inflammatory homeostasis observed in conditions such as sepsis (acute) or obesity (chronic). Secreted and transmembrane protein 1a (Sectm1a) has previously been implicated to regulate inflammatory responses, yet its role in inflammation-associated cardiac dysfunction is virtually unknown. ...
Kunnumakkara, Ajaikumar B. Rana, Varsha Parama, Dey Banik, Kishore Girisa, Sosmitha Sahu, Henamayee Thakur, Krishan Kumar Dutta, Uma Garodia, Prachi Gupta, Subash C.
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Published in
Life Sciences
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Maul, Holger Kunze, Mirjam Berger, Richard
Published in
Der Gynakologe
Bei ca. 3 % der Schwangerschaften kommt es zu einem frühen vorzeitigen Blasensprung („preterm premature rupture of the membranes“, PPROM). Da bei PPROM mit hoher Wahrscheinlichkeit mit einer MIAC („microbial invasion of the amniotic cavity“) – bereits vorbestehend oder sekundär nach Blasensprung – zu rechnen ist, ist auch die Wahrscheinlichkeit für...
Rinaldi, Fabio Trink, Anna Giuliani, Giammaria Pinto, Daniela
Published in
Dermatology and Therapy
Introduction The inflammation storm involved in coronavirus disease 2019 (COVID-19) infection and worsening and the psychological stress derived from current quarantine conditions can affect the course of many skin and scalp conditions. This study examined the possible effects of COVID‐19 on alopecia areata (AA) relapse in patients suffering from t...
Xia, Guozhi Fan, Di Ma, Chaoran He, Yanru Wang, Ming Zhu, Yaowu Zheng, Qiangsun
Published in
The American Journal of the Medical Sciences
Background Coronavirus disease 2019 (COVID-19) is still ongoing throughout the world and has resulted in considerable fatality. Inflammation and cardiac injury are commonly observed in these cases. However, the association between the hyper-inflammatory response and cardiac injury among patients with COVID-19 remains unknown. Methods The study was ...
Patt, Nadine Kool, Jan Hersche, Ruth Oberste, Max Walzik, David Joisten, Niklas Caminada, Daniel Ferrara, Francesca Gonzenbach, Roman Nigg, Claudio Renato
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Published in
BMC neurology
Persons with multiple sclerosis (PwMS) often have reduced aerobic capacity and report fatigue as the most disabling symptom impacting their health-related quality of life (HRQoL). A multidisciplinary rehabilitation approach is recommended for successful management of symptoms, although there is little supporting evidence. The aim of this study is t...
Sun, Minghui Wang, Weijun Min, Lingtian Chen, Cheng Li, Qing Weng, Wenjie
Published in
Journal of orthopaedic surgery and research
Secreted frizzled-related protein 5 (SFRP5) is an endogenous inhibitor of Wnt5a (wingless-type family member 5a), which has been implicated in anti-inflammatory response. In this study, we aimed to investigate whether SFRP5 could protect chondrocytes against LPS-induced inflammation and apoptosis. ATDC5 cells that overexpressed with SFRP5 or not we...
