Green, Jeremy Bin Mahmood, Syed Usman Mori, Makoto Yousef, Sameh Mangi, Abeel A. Geirsson, Arnar
Published in
Journal of Cardiothoracic Surgery
BackgroundElevated white blood cell counts and leukocyte ratios are recognized markers of systemic inflammation associated with poor surgical outcomes. We analyzed the temporal stability and prognostic value of the preoperative Neutrophil-to-Lymphocyte ratio (NLR) and Lymphocyte-to-Neutrophil ratio (LNR) in patients undergoing coronary artery bypas...
Leavey, Nick Hammond, Simon P. Shepstone, Lee Cross, Jane Zetterberg, Henrik Cunningham, Colm MacLullich, Alasdair Leiv Otto Watne, Minihane, Anne Marie Ballard, Clive
...
Published in
BMC Neurology
BackgroundHip fracture represents a substantial acute inflammatory trauma, which may constitute a significant insult to the degenerating brain. Research suggests that an injury of this kind can affect memory and thinking in the future but it is unclear whether, and how, inflammatory trauma injures the brain. The impact of Acute SystematiC inflammat...
D’Addabbo, Jessica Wardak, Mirwais Nguyen, Patricia K.
Published in
Current Cardiovascular Imaging Reports
Purpose of ReviewDespite advances in medical and surgical therapy, some patients after a myocardial infarction still develop heart failure, a devastating disease that has a high rate of morbidity and mortality. Differences in the immune response to the myocardial damage may affect the healing process. Molecular imaging enables the interrogation of ...
Mxinwa, Vuyolwethu Nyambuya, Tawanda M. Dludla, Phiwayinkosi V. Nkambule, Bongani B.
Published in
Systematic Reviews
BackgroundPersistent levels of low-grade inflammation and T lymphocyte activation are associated with insulin resistance and type 2 diabetes that eventually lead to the development of cardiovascular diseases. Interestingly, increasing studies report on an emerging role of innate lymphoid cells in the development of both type 2 diabetes and cardiova...
Flannagan, Kerry S. Sjaarda, Lindsey A. Hill, Micah J. Connell, Matthew T. Zolton, Jessica R. Perkins, Neil J. Mumford, Sunni L. Plowden, Torie C. Andriessen, Victoria C. Radoc, Jeannie G.
...
Published in
Reproductive Health
BackgroundInflammation and elevated blood lipids are associated with infertility. Aspirin and statin therapy may improve infertility treatment outcomes among overweight and obese women with systemic inflammation, but little is known about the short-term effects of statins in this population. We conducted a pilot study of aspirin, pravastatin, or co...
Ebert, Gregor Paradkar, Prasad N. Londrigan, Sarah L.
Published in
Virology Journal
The aim of this article is to summarise the virology content presented at the 9th Lorne Infection and Immunity Conference, Australia, in February 2019. The broad program included virology as a key theme, and the commentary herein highlights several key virology presentations at the meeting.
Domingues, Cleyton C. Kundu, Nabanita Kropotova, Yana Ahmadi, Neeki Sen, Sabyasachi
Published in
Stem Cell Research & Therapy
BackgroundThe incidence of obesity and diabetes is increasing rapidly. Optimal management is still elusive. Obesity associated with type 2 diabetes is known to cause adipose tissue inflammation, increase oxidative stress, and cause white fat hyperplasia and mitochondrial dysfunction. In this study, we investigated whether mitochondrial and cytosoli...
Karakula-Juchnowicz, Hanna Rog, Joanna Juchnowicz, Dariusz Łoniewski, Igor Skonieczna-Żydecka, Karolina Krukow, Paweł Futyma-Jedrzejewska, Malgorzata Kaczmarczyk, Mariusz
Published in
Nutrition Journal
BackgroundCurrent treatment of major depressive disorder (MDD) often does not achieve full remission of symptoms. Therefore, new forms of treatment and/or adjunct therapy are needed. Evidence has confirmed the modulation of the gut–brain–microbiota axis as a promising approach in MDD patients. The overall purpose of the SANGUT study—a 12-week, rand...
Shen, Hsin-Hsueh Yang, Chien-Yi Kung, Ching-Wen Chen, Shu-Ying Wu, Hong-Min Cheng, Pao-Yun Lam, Kwok-Keung Lee, Yen-Mei
Published in
Journal of Biomedical Science
BackgroundLoss of ovarian function, as in menopause or after ovariectomy (OVX), is closely associated with obesity and white adipose tissue (WAT) inflammation. Estrogen replacement protects against postmenopausal obesity but increases the risks of carcinogenesis. In the present study, we investigated the effects of long-term treatment of raloxifene...
Vecchio, Federica Messina, Gloria Giovenzana, Anna Petrelli, Alessandra
Published in
Current Diabetes Reports
Purpose of ReviewType 1 diabetes (T1D) is one of the most frequent chronic autoimmune diseases in humans, characterized by the lack of insulin production resulting in high blood glucose levels and lifelong requirement of exogenous insulin administration for survival. It is now recognized that the autoimmune process begins years before the clinical ...
