Dioh, W. Chabane, M. Tourette, C. Azbekyan, A. Morelot-Panzini, C. Hajjar, L. A. Lins, M. Nair, G. B. Whitehouse, T. Mariani, J.
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Published in
Trials
ObjectivesAs of December, 1st, 2020, coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2, resulted in more than 1 472 917 deaths worldwide and death toll is still increasing exponentially. Many COVID-19 infected people are asymptomatic or experience moderate symptoms and recover without medical intervention. However, older people and those wit...
Galea, Nicola Marchitelli, Livia Pambianchi, Giacomo Catapano, Federica Cundari, Giulia Birtolo, Lucia Ilaria Maestrini, Viviana Mancone, Massimo Fedele, Francesco Catalano, Carlo
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Published in
Journal of Cardiovascular Magnetic Resonance
BackgroundEarly detection of myocardial involvement can be relevant in coronavirus disease 2019 (COVID-19) patients to timely target symptomatic treatment and decrease the occurrence of the cardiac sequelae of the infection. The aim of the present study was to assess the clinical value of cardiovascular magnetic resonance (CMR) in characterizing my...
Vahdat, Mahsa Hosseini, Seyed Ahmad Soltani, Farhad Cheraghian, Bahman Namjoonia, Masih
Published in
Nutrition Journal
BackgroundTraumatic brain injury is a public health concern and is the main cause of death among various types of trauma. The inflammatory conditions due to TBI are associated with unfavorable clinical outcomes. Taurine has been reported to have immune-modulatory effects. Thus, the aim of this study was to survey the effect of taurine supplementati...
Aksnes, Mari Aass, Hans Christian D. Tiiman, Ann Edwin, Trine Holt Terenius, Lars Bogdanović, Nenad Vukojević, Vladana Knapskog, Anne-Brita
Published in
Translational Neurodegeneration
BackgroundThe aggregation of amyloid β (Aβ) is central in the pathogenesis of Alzheimer’s disease (AD). Recently it has been shown that specifically, larger, Thioflavin T-binding Aβ aggregates are associated with increased neuroinflammation and cytokine release. This study was aimed to quantify fibrillary amyloid aggregates, so-called nanoplaques, ...
Hur, Benjamin Gupta, Vinod K. Huang, Harvey Wright, Kerry A. Warrington, Kenneth J. Taneja, Veena Davis, John M. III Sung, Jaeyun
Published in
Arthritis Research & Therapy
BackgroundRheumatoid arthritis (RA) is a chronic, autoimmune disorder characterized by joint inflammation and pain. In patients with RA, metabolomic approaches, i.e., high-throughput profiling of small-molecule metabolites, on plasma or serum has thus far enabled the discovery of biomarkers for clinical subgroups, risk factors, and predictors of tr...
Liu, Keyun Sun, Jia Shao, Lingling He, Hongwei Liu, Qinglin Li, Youxiang Ge, Huijian
Published in
Chinese Neurosurgical Journal
BackgroundWe investigated whether periodontal diseases, specifically, periodontitis and gingivitis, could be risk factors of the incidence of intracranial aneurysms (IAs).MethodsWe performed a case–control study to compare the differences in the periodontal disease parameters of 281 cases that were divided into the IAs group and non-IAs group. All ...
Wang, Sijiao Jiang, Zhilong Li, Liyang Zhang, Jun Zhang, Cuiping Shao, Changzhou
Published in
Respiratory Research
BackgroundRespiratory fungal exposure is known to be associated with various allergic pulmonary disorders. Eosinophils have been implicated in tissue homeostasis of allergic inflammation as both destructive effector cells and immune regulators. What contributions eosinophils have in Aspergillus fumigatus (Af)-induced allergic lung inflammation is w...
Yang, Huan Lundbäck, Peter Ottosson, Lars Erlandsson-Harris, Helena Venereau, Emilie Bianchi, Marco E. Al-Abed, Yousef Andersson, Ulf Tracey, Kevin J.
Published in
Molecular Medicine
BackgroundHigh mobility group box 1 (HMGB1) is a nuclear protein with extracellular inflammatory cytokine activity. It is passively released during cell death and secreted by activated cells of many lineages. HMGB1 contains three conserved redox-sensitive cysteine residues: cysteines in position 23 and 45 (C23 and C45) can form an intramolecular di...
Zhou, Danling Huang, Hong Yu, Junrong Hu, Zuming
Published in
Microchimica Acta
Lysosome-targetable selenium-doped carbon nanodots (Lyso-Se-CDs) that can efficiently scavenge lysosomal •OH in living cells and mice were designed in this research. Se-CDs with redox-responsive fluorescence (λex = 379 nm, λem = 471 nm, quantum yield = 7.1%) were initially synthesized from selenocystine by a facile hydrothermal method, followed by ...
Faura, Júlia Bustamante, Alejandro Miró-Mur, Francesc Montaner, Joan
Published in
Journal of Neuroinflammation
Stroke produces a powerful inflammatory cascade in the brain, but also a suppression of the peripheral immune system, which is also called stroke-induced immunosuppression (SIIS). The main processes that lead to SIIS are a shift from a lymphocyte phenotype T-helper (Th) 1 to a Th2 phenotype, a decrease of the lymphocyte counts and NK cells in the b...
