Balzano, Tiziano Pineda-Pardo, José A Esteban-García, Noelia López-Aguirre, Miguel Reinares-Sebastián, Alejandro Trigo-Damas, Inés Takada, Masahiko Obeso, José A Blesa, Javier
Published in
Journal of controlled release : official journal of the Controlled Release Society
Low-intensity focused ultrasound (LIFU) combined with intravenously circulating microbubbles has recently emerged as a novel approach for increasing delivery through the blood-brain barrier (BBB). This technique safely and transiently enables therapeutic agents to overcome the BBB, which typically poses a significant obstacle for treatment of brain...
Nakajima, Mayuka Kapate, Neha Clegg, John R Ikeda-Imafuku, Mayumi Park, Kyung Soo Kumbhojkar, Ninad Suja, Vinny Chandran Prakash, Supriya Wang, Lily Li-Wen Tabeta, Koichi
...
Published in
Journal of controlled release : official journal of the Controlled Release Society
Cell immunotherapy is a promising therapeutic modality to combat unmet medical needs. Macrophages offer a prominent cell therapy modality since their phenotypic plasticity allows them to perform a variety of roles including defending against pathogens, inducing/suppressing adaptive immunity, and aiding in wound healing. At the same time, this plast...
Zhou, Xueyan Xu, Zunkai Dong, Yanliang Cai, Maoyu Chen, Zhixia Mu, Jingqing Yuan, Bo Hua, Xia Yuan, Xiaoyong Guo, Shutao
...
Published in
Journal of controlled release : official journal of the Controlled Release Society
Long-acting injectable formulations of dexamethasone with minimal invasiveness are highly desired to manage chronic ocular inflammatory conditions. Here, we applied microcrystals (MCs) of a hydrophobic acetone-based ketal-linked prodrug of dexamethasone (SKD) to treat postoperative ocular inflammation. We compared the efficacy and safety of SKD MCs...
Chimienti, Raniero Torchio, Silvia Siracusano, Gabriel Zamarian, Valentina Monaco, Laura Lombardo, Marta Tiffany Pellegrini, Silvia Manenti, Fabio Cuozzo, Federica Rossi, Greta
...
Published in
Diabetologia
Wolfram syndrome 1 (WS1) is an inherited condition mainly manifesting in childhood-onset diabetes mellitus and progressive optic nerve atrophy. The causative gene, WFS1, encodes wolframin, a master regulator of several cellular responses, and the gene's mutations associate with clinical variability. Indeed, nonsense/frameshift variants correlate wi...
Jolink, Tatum A Way, Baldwin M Younge, Ayana Algoe, Sara B
Published in
Brain, behavior, and immunity
Much evidence on heightened inflammation and social behavior focuses on social withdrawal. Building on recent theory (Muscatell and Inagaki, 2021), we focused instead on the socially affiliative experience of sex. We investigated the interplay between immunology and motivation on sexual well-being among 158 individuals in romantic relationships. In...
Alley, Jenna Gassen, Jeffrey Slavich, George M
Published in
Brain, behavior, and immunity
Although early adversity is now recognized as a major public health concern, it remains unclear if the effects of early-life stressors on disease biology and health differ by sex or stressor type. Because childhood stressors often covary, examining whether such stressors typically occur together (e.g., cumulative adversity) or in distinct multivari...
Meier, Daniel T de Paula Souza, Joyce Donath, Marc Y
Published in
Diabetologia
Increased activity of the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome-IL-1β pathway is observed in obesity and contributes to the development of type 2 diabetes and its complications. In this review, we describe the pathological activation of IL-1β by metabolic stress, ageing and the microbiome and present data on the role ...
Choo, Charlene Cote, Olivia Bostwick, Karina Regueiro, Matthew Wells, Jill Grossniklaus, Hans E Gonzales, John Yeh, Steven Hinterwirth, Armin Doan, Thuy
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PurposeTo compare the diagnostic utility of metagenomic deep sequencing (MDS) to cytology, flow cytometry and gene rearrangement by PCR in ocular samples of patients with suspected vitreoretinal lymphoma (VRL).MethodsPatients with suspected VRL underwent ocular sampling of one or both eyes at the Emory Eye Center from September 2017 to June 2022. O...
Lundin, Jessica I Peters, Ulrike Hu, Yao Ammous, Farah Avery, Christy L Benjamin, Emelia J Bis, Joshua C Brody, Jennifer A Carlson, Chris Cushman, Mary
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Systemic low-grade inflammation is a feature of chronic disease. C-reactive protein (CRP) is a common biomarker of inflammation and used as an indicator of disease risk; however, the role of inflammation in disease is not completely understood. Methylation is an epigenetic modification in the DNA which plays a pivotal role in gene expression. In th...
Nevzati, Edin Rey, Jeannine Spiessberger, Alexander Moser, Manuel Roethlisberger, Michel Grüter, Basil Erwin Widmer, Hans Rudolf Coluccia, Daniel Marbacher, Serge
Published in
Journal of neurointerventional surgery
Biodegradable materials that dissolve after aneurysm healing are promising techniques in the field of neurointerventional surgery. We investigated the effects of various bioabsorable materials in combination with degradable magnesium alloy stents and evaluated aneurysm healing in a rat aneurysm model. Saccular aneurysms were created by end-to-side ...
