Pokutnaya, Darya Van Panhuis, Willem G Childers, Bruce Hawkins, Marquis S Arcury-Quandt, Alice E Matlack, Meghan Carpio, Kharlya Hochheiser, Harry
Published in
BMC infectious diseases
Infectious disease computational modeling studies have been widely published during the coronavirus disease 2019 (COVID-19) pandemic, yet they have limited reproducibility. Developed through an iterative testing process with multiple reviewers, the Infectious Disease Modeling Reproducibility Checklist (IDMRC) enumerates the minimal elements necessa...
Greenbaum, Wyatt H Greenbaum, Garrett J Spiezio, Anna
Over past few decades, new insight has been revealed in the scientific community about the importance of the human gut microbiome relating to general health. It is known that imbalances in the species that reside in the human gut can cause organism-wide problems in humans. When prescribing or injecting oral medications, the thought of the downstrea...
Fredericks-Younger, Janine Feldman, Cecile Allareddy, Veerasathpurush Funkhouser, Ellen McBurnie, MaryAnn Meyerowitz, Cyril Ragusa, Pat Chapman-Greene, Julie Coker, Modupe Fine, Daniel H
...
Published in
Research square
The COVID-19 pandemic highlights the need for practitioners to enhance workflows to increase safety and mitigate risk. As dental practice creates a highly aerosolized environment, pre-visit testing for SARS-CoV-2 has the potential to be an effective mitigation strategy to minimize disease transmission in dental offices. The Pragmatic Return to Effe...
Ruland, Jürgen
Published in
Cell
Microbial and danger signals result in inflammasome activation and release of inflammatory cytokines through mechanisms that remain elusive. Cai et al. and Lu et al. show that triggering of inflammasome sensors induces prion-like polymerization of the adaptor ASC into filaments. These structures function as platforms for inflammatory cytokine produ...
Jiang, Yvonne Angeletti, Peter C. Hoffman, Amy J.
This literature review examines the mechanisms of how exercise, specifically in the form of resistance training, may lead to pain relief in the cancer population. Primary data from three different cancer populations: breast, prostate, and lung, will be examined. A number of experimental studies have been conducted to confirm the effectiveness of re...
Sexton, Nicole R. Cline, Parker Parker Gallichotte, Emily N. Fitzmeyer, Emily Young, Michael C. Janich, Ashley J. Pabilonia, Kristy L. Ehrhart, Nicole Ebel, Gregory D.
SARS-CoV-2 belongs to the family Coronaviridae which includes multiple human pathogens that have an outsized impact on aging populations. As a novel human pathogen, SARS-CoV-2 is undergoing continuous adaptation to this new host species and there is evidence of this throughout the scientific and public literature. However, most investigations of SA...
Julius, Peter Siyumbwa, Stepfanie N. Maate, Fred Moonga, Phyllis Kang, Guobin Kaile, Trevor T., John T. Wood, Charles
Yes-associated protein-1 (YAP-1) is a Hippo system transcription factor, which serves as an oncogene in squamous cell carcinoma, and several solid tumors when the Hippo pathway is dysregulated. Yet, the activity of YAP-1 in ocular surface squamous neoplasia (OSSN) has not been determined. Here, we investigate the relationship between YAP-1 overexpr...
Esmael, Ahmed Agarkova, Irina V. Dunigan, David D Zhou, You Van Etten, James L.
Many chloroviruses replicate in Chlorella variabilis algal strains that are ex-endosymbionts isolated from the protozoan Paramecium bursaria, including the NC64A and Syngen 2-3 strains. We noticed that indigenous water samples produced a higher number of plaque-forming viruses on C. variabilis Syngen 2-3 lawns than on C. variabilis NC64A lawns. The...
Sreenivasan, Chithra C. Liu, Runxia Gao, Rongyuan Guo, Yicheng Hause, Ben M. Thomas, Milton Naveed, Ahsan Clement, Travis Rausch, Dana Christopher-Hennings, Jane
...
Influenza C virus (ICV) is increasingly associated with community-acquired pneumonia (CAP) in children and its disease severity is worse than the influenza B virus, but similar to influenza A virus associated CAP. Despite the ubiquitous infection landscape of ICV in humans, little is known about its replication and pathobiology in animals. The goal...
Petro-Turnquist, Erika M. Pekarek, Matthew J. Jeanjaquet, Nicholas Wooledge, Cedric Steffen, David J. Vu, Hiep Weaver, Eric A.
Current methods of vaccination against swine Influenza A Virus (IAV-S) in pigs are infrequently updated, induce strain-specific responses, and have a limited duration of protection. Here, we characterize the onset and duration of adaptive immune responses after vaccination with an adenoviral-vectored Epigraph vaccine. In this longitudinal study we ...
