Kumar, Anand Teslova, Tatiana Taub, Erin Miller, Joshua D Lukin, Dana J
Published in
Digestive diseases and sciences
Diabetes mellitus (DM) and inflammatory bowel diseases (IBD) are chronic systemic illnesses associated with chronic inflammation, dysbiosis, impaired immune function, and infection risk. The impact of DM in modifying disease activity in patients with IBD remains largely unknown. To investigate the impact of DM on IBD-related disease outcomes, morta...
Fariñas, Maria Carmen González-Rico, Claudia Fernández-Martínez, Marta Fortún, Jesús Escudero-Sanchez, Rosa Moreno, Asunción Bodro, Marta Muñoz, Patricia Valerio, Maricela Montejo, Miguel
...
Published in
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
To evaluate the efficacy of oral colistin-neomycin in preventing multidrug-resistant Enterobacterales (MDR-E) infections in solid organ transplant (SOT) recipients. Multicentre, open-label, parallel-group, controlled trial with balanced (1:1) randomization in five transplant units. SOT recipients were screened for MDR-E intestinal colonization (ext...
Nudel, Ron Allesøe, Rosa Lundbye Thompson, Wesley K. Werge, Thomas Rasmussen, Simon Benros, Michael E.
Published in
Journal of Translational Medicine
BackgroundInfections are a major disease burden worldwide. While they are caused by external pathogens, host genetics also plays a part in susceptibility to infections. Past studies have reported diverse associations between human leukocyte antigen (HLA) alleles and infections, but many were limited by small sample sizes and/or focused on only one ...
Botwe, Akua Kyerewaa Oppong, Felix Boakye Gyaase, Stephaney Owusu-Agyei, Seth Asghar, Muhammad Asante, Kwaku Poku Färnert, Anna Osier, Faith
Published in
Malaria Journal
BackgroundUnderstanding why some infants tolerate infections, remaining asymptomatic while others succumb to repeated symptomatic malaria is beneficial for studies of naturally acquired immunity and can guide control interventions. This study compared demographic, host and maternal factors associated with being either parasite negative or having as...
Li, Hang Long Feng, Qi Tsoi, Man Fung Fei, Yue Cheung, Bernard M Y
Published in
European heart journal. Cardiovascular pharmacotherapy
Ticagrelor has been shown to reduce the risk of pneumonia and improve lung function, but the findings across studies were inconsistent. The objective is to investigate the relative safety of ticagrelor vs. clopidogrel on infection outcomes in patients with cardiovascular diseases. We searched MEDLINE, Embase, Cochrane Library, and ClinicalTrials.go...
Smith, Tyler Ellis Kister, Ilya
Published in
Current Neurology and Neuroscience Reports
Purpose of ReviewThe newer, higher-efficacy disease-modifying therapies (DMTs) for multiple sclerosis (MS)—orals and monoclonals—have more profound immunomodulatory and immunosuppressive properties than the older, injectable therapies and require risk mitigation strategies to reduce the risk of serious infections. This review will provide a systema...
Angermund, Almuth Inglese, Gary Goldstine, Jimena Iserloh, Laura Libutzki, Berit
Published in
BMC Urology
BackgroundIntermittent catheterization (IC) is a common medical technique to drain urine from the bladder when this is no longer possible by natural means. The objective of this study was to evaluate the standard of care and the burden of illness in German individuals who perform intermittent catheterization and obtain recommendations for improveme...
Alford, Elizabeth N Chagoya, Gustavo Elsayed, Galal A Bernstock, Joshua D Bentley, J Nicole Romeo, Andrew Guthrie, Barton
Published in
Neurosurgical review
Retrosigmoid craniotomy for microvascular decompression (MVD) has been traditionally performed via craniectomy. Various closure techniques have been described, yet factors associated with wound-related complications remain undetermined. Accordingly, herein, we sought to identify risk factors associated with wound-related complications after such pr...
Thomas, Konstantinos Argyriou, Evangelia Kapsala, Noemin Panagiotopoulos, Alexandros Chalkia, Aglaia Hadziyannis, Emilia Boki, Kyriaki Katsimbri, Pelagia Boumpas, Dimitrios T. Giannou, Panagiota
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Published in
Arthritis Research & Therapy
BackgroundSerious infections (SI) are common in patients with ANCA-associated vasculitides (AAV) like granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). Real-life data regarding their incidence and predisposing factors—after the introduction of B cell depleting agents—are limited while data quantifying the risk per treatment...
Keyßer, Gernot
Published in
Zeitschrift Fur Rheumatologie
Glukokortikoide (GC) werden für die initiale Therapie der RA nach wie vor empfohlen – zeitlich befristet und in geringstmöglicher Dosierung. Ihre komplexe Wirkweise geht mit Nebenwirkungen einher, die v. a. in der Dauertherapie oberhalb von 5 mg Prednisolon pro Tag eine Rolle spielen. In diesem Dosisbereich begünstigen sie Osteoporose, Diabetes/Hyp...
