Hoppe, Charis Holt, Derick G Arnold, Benjamin F Thinda, Sumeer Padmanabhan, Sriranjani P Oatts, Julius T
PurposeTo evaluate refractive and structural outcomes for patients treated for retinopathy of prematurity (ROP) with the anti-vascular endothelial growth factor (anti-VEGF) agent ranibizumab and "delayed laser," defined as any laser photocoagulation treatment administered at least 2 weeks and
Sié, Ali Bountogo, Mamadou Zakane, Alphonse Compaoré, Guillaume Ouedraogo, Thierry Lebas, Elodie Nyatigo, Fanice Hu, Huiyu Brogdon, Jessica Arnold, Benjamin F
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Mass azithromycin distribution reduces all-cause childhood mortality in some high-mortality settings in sub-Saharan Africa. Although the greatest benefits have been shown in children 1 to 5 months old living in areas with high mortality rates, no evidence of a benefit was found of neonatal azithromycin in a low-mortality setting on mortality at 6 m...
Wang, Yuejun Jessie Zhang, Xicheng Lam, Chi Keung Guo, Hongchao Wang, Cheng Zhang, Sai Wu, Joseph C Snyder, Michael Li, Jingjing
Despite a strong genetic component, only a few genes have been identified in congenital heart diseases (CHDs). We introduced systems analyses to uncover the hidden organization on biological networks of mutations in CHDs and leveraged network analysis to integrate the protein interactome, patient exomes, and single-cell transcriptomes of the develo...
Blair, Alden Hooper Openshaw, Maria Mphande, Isaac Jana, Oveka Malirakwenda, Richard Muller, Anna Rankin, Sally Baltzell, Kimberly
IntroductionDespite successful efforts to improve clinical access and skilled birth attendance in Malawi, it still faces high rates of maternal and neonatal mortality. In 2017, the UCSF-GAIN partnership began a nurse-midwifery clinical education and longitudinal mentorship program. While it has received positive reviews, it is unclear whether routi...
Eick, Stephanie M Cushing, Lara Goin, Dana E Padula, Amy M Andrade, Aileen DeMicco, Erin Woodruff, Tracey J Morello-Frosch, Rachel
Living in a disadvantaged neighborhood has been associated with adverse birth outcomes. Most prior studies have conceptualized neighborhoods using census boundaries and few have examined the role of neighborhood perceptions, which may better capture the neighborhood environment. In the present study, we examined associations between extrinsic and p...
Bakhtsiyarava, Maryia Ortigoza, Ana Sánchez, Brisa N Braverman-Bronstein, Ariela Kephart, Josiah L Rodríguez López, Santiago Rodríguez, Jordan Diez Roux, Ana V
BackgroundExtreme temperatures may lead to adverse pregnancy and birth outcomes, including low birthweight. Studies on the impact of temperature on birthweight have been inconclusive due to methodological challenges related to operationalizing temperature exposure, the definitions of exposure windows, accounting for gestational age, and a limited g...
Neves, Paulo Augusto Ribeiro Vaz, Juliana S Ricardo, Luiza IC Armenta-Paulino, Nancy N Barros, Aluísio JD Richter, Linda Rollins, Nigel Peréz-Escamilla, Rafael
BACKGROUND: Early initiation of breast feeding (EIBF) reduces the risk of neonatal mortality. However, only 45% of newborns are breast-fed within the first hour after birth and prelacteal feeding (PLF) is widely prevalent in low- and middle-income countries (LMICs). OBJECTIVE: To assess within- and between-country disparities in EIBF and PLF practi...
Giuliani, Francesca Oros, Daniel Gunier, Robert B Deantoni, Sonia Rauch, Stephen Casale, Roberto Nieto, Ricardo Bertino, Enrico Rego, Albertina Menis, Camilla
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BackgroundThe effect of COVID-19 in pregnancy on maternal outcomes and its association with preeclampsia and gestational diabetes mellitus have been reported; however, a detailed understanding of the effects of maternal positivity, delivery mode, and perinatal practices on fetal and neonatal outcomes is urgently needed.ObjectiveTo evaluate the impa...
Chen, Melissa J Kair, Laura R Schwarz, E Bimla Creinin, Mitchell D Chang, Judy C
BackgroundPostpartum contraception counseling and method use vary widely among patients who had a preterm birth. We performed this study to explore what issues and concerns individuals with preterm infants requiring intensive care describe as influencing their postpartum contraceptive choices.MethodsWe conducted a qualitative study using semi-struc...
Vaaben, Anna V Levan, Justine Nguyen, Catherine BT Callaway, Perri C Prahl, Mary Warrier, Lakshmi Nankya, Felistas Musinguzi, Kenneth Kakuru, Abel Muhindo, Mary K
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BackgroundCongenital cytomegalovirus (CMV) infection is the most common infectious cause of birth defects and neurological damage in newborns. Despite a well-established role for natural killer (NK) cells in control of CMV infection in older children and adults, it remains unknown whether fetal NK cells can sense and respond to CMV infection acquir...