Morello, William; Baskin, Esra; Jankauskiene, Augustina; Yalcinkaya, Fatos; Zurowska, Aleksandra; Puccio, Giuseppe; Serafinelli, Jessica; La Manna, Angela; Krzemień, Grażyna; Pennesi, Marco;
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BACKGROUND: The efficacy of continuous antibiotic prophylaxis in preventing urinary tract infection (UTI) in infants with grade III, IV, or V vesicoureteral reflux is controversial. METHODS: In this investigator-initiated, randomized, open-label trial performed in 39 European centers, we randomly assigned infants 1 to 5 months of age with grade III...
Valabregue, R Girka, F Pron, A Rousseau, F Auzias, G
Brain segmentation from neonatal MRI images is a very challenging task due to large changes in the shape of cerebral structures and variations in signal intensities reflecting the gestational process. In this context, there is a clear need for segmentation techniques that are robust to variations in image contrast and to the spatial configuration o...
Choe, Goun Park, Su-Kyoung Kim, Bong Jik
Published in
Clinical and experimental pediatrics
Hearing in neonates and infants is crucial for their development of language and communication skills. Unless hearing loss is appropriately managed early, it can cause a significant socioeconomic burden considering its detrimental impact on the child's development and its common nature. It is also the most common congenital sensory deficit, with an...
Wu, Yvonne Monsell, Sarah Glass, Hannah Wisnowski, Jessica Mathur, Amit McKinstry, Robert Bluml, Stefan Comstock, Bryan Heagerty, Patrick Juul, Sandra
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BACKGROUND: In newborns with hypoxic-ischemic encephalopathy (HIE), the correlation between neonatal neuroimaging and the degree of neurodevelopmental impairment (NDI) is unclear. METHODS: Infants with HIE enrolled in a randomized controlled trial underwent neonatal MRI/MR spectroscopy (MRS) using a harmonized protocol at 4-6 days of age. The sever...
Mei, Jenny Mok, Thalia Cambou, Mary Fuller, Trevon Fajardo, Viviana Kerin, Tara Han, Christina Nielsen-Saines, Karin Rao, Rashmi
BACKGROUND: On the basis of available data, at least 1 ultrasound assessment of pregnancies recovering from SARS-CoV-2 infection is recommended. However, reports on prenatal imaging findings and potential associations with neonatal outcomes following SARS-CoV-2 infection in pregnancy have been inconclusive. OBJECTIVE: This study aimed to describe t...
Lee, Martin Rechtman, David Sun, Adam Autran, Chloe Niklas, Victoria Jacobs, Jonathan
Human milk contains over 200 distinct oligosaccharides, which are critical to shaping the developing neonatal gut microbiome. To investigate whether a complex mixture of human milk oligosaccharides (HMOs) would similarly modulate the adult gut microbiome, HMO-Concentrate derived from pooled donor breast milk was administered orally to 32 healthy ad...
Prem, Kiesha Choi, Yoon Hong Bénard, Élodie Burger, Emily A Hadley, Liza Laprise, Jean-François Regan, Mary Caroline Drolet, Mélanie Sy, Stephen Portnoy, Allison
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Funder: Fonds de recherche du Québec – Nature et technologies / Funder: Compute Canada / BackgroundTo eliminate cervical cancer as a public health problem, the World Health Organization had recommended routine vaccination of adolescent girls with two doses of the human papillomavirus (HPV) vaccine before sexual initiation. However, many countries h...
Clark, Kristen Lunn, Mitchell Bosse, Jordon Weiss, Sandra Lubensky, Micah Obedin-Maliver, Juno Flentje, Annesa Dawson-Rose, Carol Sevelius, Jeanne
BACKGROUND: Gender minority (GM; individuals whose gender is not aligned with that traditionally associated with the sex that was assigned to them at birth) people have widely reported mistreatment in healthcare settings. Mistreatment is enacted by individuals within society who hold stigmatizing beliefs. However, the relationship between healthcar...
Gay, Caryl Hoffmann, Thomas Kriz, Rebecca Bisgaard, Robin Cormier, Diana Joe, Priscilla Lothe, Brittany Sun, Yao Franck, Linda
BACKGROUND: Involvement in caregiving and tailored support services may reduce the risk of mental health symptoms for mothers after their preterm infants neonatal intensive care unit (NICU) discharge. We aimed to compare Family-Centered Care (FCC) with mobile-enhanced Family-Integrated Care (mFICare) on post-discharge maternal mental health symptom...
Kasim, Hanis Hidayu Olga, Laurentya Snowden, Stuart Cropp, Eliza Koulman, Albert Beardsall, Kathryn
BACKGROUND: Desaturase enzymes play a key role in several pathways including biosynthesis of poly- and mono- unsaturated fatty acids (PUFAs, MUFA). In preterm infants, desaturase enzyme activity (DA) may be a rate-limiting step in maintaining PUFAs levels during this critical developmental window and impact on long term metabolic health. The study ...