Surendran, Harshini Nandakumar, Swapna Reddy K, Vijay Bhaskar Stoddard, Jonathan Mohan K, Varsha Upadhyay, Pramod K. McGill, Trevor J. Pal, Rajarshi
Published in
Stem Cell Research & Therapy
Background Age-related macular degeneration (AMD) is a result of degeneration/damage of the retinal pigment epithelium (RPE) while retinitis pigmentosa (RP), an inherited early-onset disease, results from premature loss of photoreceptors. A promising therapeutic approach for both is the replacement of lost/damaged cells with human induced pluripote...
Wu, Chia-Lung Dicks, Amanda Steward, Nancy Tang, Ruhang Katz, Dakota B. Choi, Yun-Rak Guilak, Farshid
Published in
Nature Communications
Application of human induced pluripotent stem cells (hiPSCs) for tissue regeneration is hindered by off-target cell differentiation. Here, the authors use bulk and single cell RNA-sequencing to identify WNT and MITF as off-target hubs during chondrogenic differentiation; inhibiting these pathways enhanced homogeneity and yield.
Borys, Breanna S. Dang, Tiffany So, Tania Rohani, Leili Revay, Tamas Walsh, Tylor Thompson, Madalynn Argiropoulos, Bob Rancourt, Derrick E. Jung, Sunghoon
...
Published in
Stem Cell Research & Therapy
BackgroundHuman induced pluripotent stem cells (hiPSCs) hold enormous promise in accelerating breakthroughs in understanding human development, drug screening, disease modeling, and cell and gene therapies. Their potential, however, has been bottlenecked in a mostly laboratory setting due to bioprocess challenges in the scale-up of large quantities...
Zhao, Qingguo Hai, Bo Kelly, Jack Wu, Samuel Liu, Fei
Published in
Stem Cell Research & Therapy
BackgroundExtracellular vesicles (EVs) and their mimics from mesenchymal stem cells (MSCs) are promising drug carriers to improve cancer treatment, but their application is hindered by donor variations and expansion limitations of conventional tissue-derived MSCs. To circumvent these issues, we made EV-mimicking nanovesicles from standardized MSCs ...
Jiang, Yu Sun, Si-Jia Zhen, Zhe Wei, Rui Zhang, Nannan Liao, Song-Yan Tse, Hung-Fat
Published in
Stem Cell Research & Therapy
BackgroundThe creation of a bioengineered cardiac patch (BCP) is a potential novel strategy for myocardial repair. Nevertheless, the ideal scaffold for BCP is unknown.ObjectiveWe investigated whether the decellularized placenta (DP) could serve as natural scaffold material to create a BCP for myocardial repair.Methods and resultsA BCP was created b...
Cheffer, Arquimedes Flitsch, Lea Jessica Krutenko, Tamara Röderer, Pascal Sokhranyaeva, Liubov Iefremova, Vira Hajo, Mohamad Peitz, Michael Schwarz, Martin Karl Brüstle, Oliver
...
Published in
Molecular Autism
The controlled differentiation of pluripotent stem cells (PSCs) into neurons and glia offers a unique opportunity to study early stages of human central nervous system development under controlled conditions in vitro. With the advent of cell reprogramming and the possibility to generate induced pluripotent stem cells (iPSCs) from any individual in ...
Scarfone, Rachel A. Pena, Samantha M. Russell, Keith A. Betts, Dean H. Koch, Thomas G.
Published in
BMC Veterinary Research
Induced pluripotent stem cells (iPSCs) are undifferentiated stem cells characterized by the ability to differentiate into any cell type in the body. iPSCs are a relatively new and rapidly developing technology in many fields of biology, including developmental anatomy and physiology, pathology, and toxicology. These cells have great potential in re...
Pavlovic, Zoran J Sax, Megan R Kim, Ashley S DeCherney, Alan H
Published in
Journal of assisted reproduction and genetics
Science, propelled forward by noble aspirations and, at times, human hubris, has the capacity to affect lives and alter the world in unanticipated ways. Even seemingly minor discoveries have repeatedly proven to have far reaching implications that experts within their respective fields could not have predicted. Nuclear technology is both a source o...
Nieves, Michael D Furmanski, Orion Doughty, Martin L
Published in
Brain research
Traumatic brain injury (TBI) is a substantial cause of disability and death worldwide. Primary head trauma triggers chronic secondary injury mechanisms in the brain that are a focus of therapeutic efforts to treat TBI. Currently, there is no successful clinical strategy to repair brain injury. Cell transplantation therapies have demonstrated promis...
Sherstyuk, Vladimir V Yanshole, Lyudmila V Zelentsova, Ekaterina A Melnikov, Arsenty D Medvedev, Sergey P Tsentalovich, Yuri P Zakian, Suren M
Published in
Stem cell reviews and reports
Metabolomic profiles of somatic cells, embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs) reflect their metabolic phenotypes. The comparative study of metabolomes of these cells is important for understanding the differences in metabolism between somatic and pluripotent cells, and also the possible differences between ESCs and ...
