De Gaetano, Federica Mannino, Deborah Celesti, Consuelo Bulzomí, Maria Iraci, Nunzio Vincenzo Giofrè, Salvatore Esposito, Emanuela Paterniti, Irene Anna Ventura, Cinzia
Published in
International journal of pharmaceutics
Neurodegenerative diseases such as Alzheimer's are very common today. Idebenone (IDE) is a potent antioxidant with good potential for restoring cerebral efficiency in cases of these and other medical conditions, but a serious drawback for the clinical use of IDE in neurological disorders lies in its scarce water solubility, which greatly inhibits i...
Agbana, Preye Park, Ji Eun Rychahou, Piotr Kim, Kyung-Bo Bae, Younsoo
Published in
Journal of pharmaceutical sciences
Carfilzomib (CFZ) is a second-generation proteasome inhibitor showing great efficacy in multiple myeloma treatment, yet its clinical applications for other diseases such as solid cancers are limited due to low aqueous solubility and poor biostability. Ternary polypeptide nanoparticles (tPNPs) are drug carriers that we previously reported to overcom...
Mahmoudi, Fatemeh Shahraki, Mehdi
Published in
Journal of biomolecular structure & dynamics
The effective detoxification of organophosphate (OP) nerve agents (OPNAs) is a challenging issue for scientists. The host-guest inclusion complexes of five V-type nerve agents (VE, VG, VM, VR and VX) with β-cyclodextrin (β-CD) have been studied by combining quantum mechanical (QM) calculations and molecular dynamics (MD) simulations. The frontier m...
Yilmaz, Aynur Sanem Ozturk, Serhat Salih, Bekir Ayyala, Ramesh S Sahiner, Nurettin
Published in
Colloids and surfaces. B, Biointerfaces
Cyclodextrins (CDs) are natural cyclic oligosaccharides with a relatively hydrophobic cavity and a hydrophilic outer surface. In this study, alpha (α-), beta (β-) and gamma (γ-) CD particles were prepared by directly using α-, β-, and γ-CDs as monomeric units and divinyl sulfone (DVS) as a crosslinker in a single-step via reverse micelle microemuls...
Khan, Waqas Haider Asghar, Sajid Khan, Ikram Ullah Irfan, Muhammad Alshammari, Abdulrahman Riaz Rajoka, Muhammad Shahid Munir, Rabia Shah, Pervaiz A Khalid, Ikrima Razzaq, Fizza Abdul
...
Published in
Heliyon
BCS class II drugs exhibit low aqueous solubility and high permeability. Such drugs often have an incomplete or erratic absorption profile. This study aimed to predict the effects of β-cyclodextrin (βCD) and different hydrophilic polymers (poloxamer 188 (PXM-188), polyvinyl pyrrolidone (PVP) and soluplus (SOLO)) on the saturated solubility and diss...
Wu, Jiulin Song, Gaojie Huang, Ruyang Yan, Yongyong Li, Qingxiang Guo, Xiaoban Shi, Xiaodan Tian, Yongqi Wang, Jianhua Wang, Shaoyun
...
Published in
Food chemistry
For food preservation, the packaging film needs to have higher antibacterial activity in initial phase and keep longer activity. In this study, cinnamaldehyde (CA) and its sulfobutyl ether-β-cyclodextrin inclusion complex (CA/S) were used to fabricate fish gelatin antibacterial composite films. The addition enhanced the elongation at break and ligh...
Zhang, Yonghua Tan, Yuanzhen OuYang, Qiuli Duan, Bin Wang, Ziting Meng, Kuixian Tan, Xiaoli Tao, Nengguo
Published in
Pesticide biochemistry and physiology
The volatility of essential oils greatly limits their industrial applications. Here, we successfully prepared γ-cyclodextrin (γ-CD) inclusion compounds (γ-CDTL) containing thymol (TL) for the control of green mold caused by Penicillium digitatum (P. digitatum) in citrus fruit. In vitro experiment showed that the minimum fungicidal concentration (MF...
Hichri, S. Matoussi, N. Abderrahim, R.
ABSTRACT. Inclusion complex between 3-amino-1,2,4-triazole picrate and β-cyclodextrin was synthesized in order to increase the picrate solubility. The complex was obtained by co-precipitation method and its stoichiometry is 1:1 (guest–host). The structure of picrate and complex has been established by UV, X-ray diffractometry powder spectra, TGA, D...
Mohandoss, Sonaimuthu Velu, Kuppu Sakthi Stalin, Thambusamy Ahmad, Naushad Alomar, Suliman Yousef Lee, Yong Rok
Published in
Journal of Molecular Liquids
Tenofovir (TFR) is an antiviral drug commonly used to fight against viral diseases infection due to its good potency and high genetic barrier to drug resistance. In physiological conditions, TFR is less water soluble, more unstable, and less permeable, limiting its effective therapeutic applications. In addition to their use in treating the Coronav...
de Souza, Viviane Costa Dos Santos Ramos, Gabriel Leite, Juliana Lago Dos Santos, Mauricio Brandão Otubo, Larissa Camargo, Zaine Teixeira Victor, Mauricio Moraes
Published in
Carbohydrate polymers
A novel, easily prepared and accessible water-soluble supramolecular catalyst for the Suzuki-Miyaura CC coupling reaction was synthesized and characterized by FTIR, NMR, XRD, SEM, and HR-TEM. An inexpensive Pd(II) source added to the resulting aqueous solution of thioglycolic ester β-cyclodextrin (1-TGA-SH-β-CD/PdCl2) showed Pd nanoclusters and eff...
