Zheng, XiaoTing Salinas, Kirstie J Velez, Dario X Figueroa Nakayama, Taylor Lin, Xiaoxiao Banerjee, Dhruba Xu, Xiangmin Gandhi, Sunil P
The adult brain lacks sensitivity to changes in the sensory environment found in the juvenile brain. The transplantation of embryonic interneurons has been shown to restore juvenile plasticity to the adult host visual cortex. It is unclear whether transplanted interneurons directly mediate the renewed cortical plasticity or whether these cells act ...
Das, Manasi Ellies, Lesley G Kumar, Deepak Sauceda, Consuelo Oberg, Alexis Gross, Emilie Mandt, Tyler Newton, Isabel G Kaur, Mehak Sears, Dorothy D
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Accumulating evidence indicates that obesity with its associated metabolic dysregulation, including hyperinsulinemia and aberrant circadian rhythms, increases the risk for a variety of cancers including postmenopausal breast cancer. Caloric restriction can ameliorate the harmful metabolic effects of obesity and inhibit cancer progression but is dif...
Kim, Jung-Hwan Matsubara, Tsutomu Lee, Jaekwon Fenollar-Ferrer, Cristina Han, Kyungreem Kim, Donghwan Jia, Shang Chang, Christopher J Yang, Heejung Nagano, Tomokazu
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The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes hepatic toxicity associated with prominent lipid accumulation in humans. Here, the authors report that the lysosomal copper transporter SLC46A3 is induced by TCDD and underlies the hepatic lipid accumulation in mice, potentially via effects on mitochondrial function. SL...
Zhong, Cuiling Li, Pin Argade, Sulabha Liu, Lixian Chilla', Anastasia Liang, Wei Xin, Hong Eliceiri, Brian Choudhury, Biswa Ferrara, Napoleone
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Endothelial cell (EC) metabolism is thought to be one of the driving forces for angiogenesis. Here we report the identification of the hexosamine D-mannosamine (ManN) as an EC mitogen and survival factor for bovine and human microvascular EC, with an additivity with VEGF. ManN inhibits glycosylation in ECs and induces significant changes in N-glyca...
Lin, Ziguang Jin, Suoqin Chen, Jefferson Li, Zhuorui Lin, Zhongqi Tang, Li Nie, Qing Andersen, Bogi
The interfollicular epidermis (IFE) forms a water-tight barrier that is often disrupted in inflammatory skin diseases. During homeostasis, the IFE is replenished by stem cells in the basal layer that differentiate as they migrate toward the skin surface. Conventionally, IFE differentiation is thought to be stepwise as reflected in sharp boundaries ...
Hultgren, Nan W Fang, Jennifer S Ziegler, Mary E Ramirez, Ricardo N Phan, Duc TT Hatch, Michaela MS Welch-Reardon, Katrina M Paniagua, Antonio E Kim, Lin S Shon, Nathan N
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Slug (SNAI2), a member of the well-conserved Snail family of transcription factors, has multiple developmental roles, including in epithelial-to-mesenchymal transition (EMT). Here, we show that Slug is critical for the pathological angiogenesis needed to sustain tumor growth, and transiently necessary for normal developmental angiogenesis. We find ...
Wang, Yifan Sangaré, Lamba Omar Paredes-Santos, Tatiana C Hassan, Musa A Krishnamurthy, Shruthi Furuta, Anna M Markus, Benedikt M Lourido, Sebastian Saeij, Jeroen PJ
Macrophages play an essential role in the early immune response against Toxoplasma and are the cell type preferentially infected by the parasite in vivo. Interferon gamma (IFNγ) elicits a variety of anti-Toxoplasma activities in macrophages. Using a genome-wide CRISPR screen we identify 353 Toxoplasma genes that determine parasite fitness in naїve ...
Yao, Catherine D Haensel, Daniel Gaddam, Sadhana Patel, Tiffany Atwood, Scott X Sarin, Kavita Y Whitson, Ramon J McKellar, Siegen Shankar, Gautam Aasi, Sumaira
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Tumor heterogeneity and lack of knowledge about resistant cell states remain a barrier to targeted cancer therapies. Basal cell carcinomas (BCCs) depend on Hedgehog (Hh)/Gli signaling, but can develop mechanisms of Smoothened (SMO) inhibitor resistance. We previously identified a nuclear myocardin-related transcription factor (nMRTF) resistance pat...
Krivanek, Jan Soldatov, Ruslan A Kastriti, Maria Eleni Chontorotzea, Tatiana Herdina, Anna Nele Petersen, Julian Szarowska, Bara Landova, Marie Matejova, Veronika Kovar Holla, Lydie Izakovicova
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Understanding cell types and mechanisms of dental growth is essential for reconstruction and engineering of teeth. Therefore, we investigated cellular composition of growing and non-growing mouse and human teeth. As a result, we report an unappreciated cellular complexity of the continuously-growing mouse incisor, which suggests a coherent model of...
Miesfeld, Joel B Ghiasvand, Noor M Marsh-Armstrong, Brennan Marsh-Armstrong, Nicholas Miller, Eric B Zhang, Pengfei Manna, Suman K Zawadzki, Robert J Brown, Nadean L Glaser, Tom
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The retinal ganglion cell (RGC) competence factor ATOH7 is dynamically expressed during retinal histogenesis. ATOH7 transcription is controlled by a promoter-adjacent primary enhancer and a remote shadow enhancer (SE). Deletion of the ATOH7 human SE causes nonsyndromic congenital retinal nonattachment (NCRNA) disease, characterized by optic nerve a...