Magri, Sara Masetto, Elena Solito, Samantha Francescato, Samuela Belluzzi, Elisa Pozzuoli, Assunta Berizzi, Antonio Ruggieri, Pietro Mandruzzato, Susanna
Published in
Immunity & Ageing
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immunosuppressive cells developing from myeloid progenitors, which are enriched in pathological conditions such as cancer, and are known to inhibit the functions of effector T cells. During aging, several changes occur both at the adaptive and innate immune system level, in ...
Guad, Rhanye Mac Taylor-Robinson, Andrew W. Wu, Yuan Seng Gan, Siew Hua Zaharan, Nur Lisa Basu, Roma Choudhury Liew, Constance Sat Lin Wan Md Adnan, Wan Ahmad Hafiz
Published in
BMC Nephrology
BackgroundNew-onset diabetes after transplantation (NODAT) is associated with reduced patient and graft survival. This study examined the clinical and selected genetic factors associated with NODAT among renal-transplanted Malaysian patients.MethodsThis study included 168 non-diabetic patients (58% males, 69% of Chinese ethnicity) who received rena...
Bellin, Melena D. Dunn, Ty B.
Published in
Diabetologia
Whole-organ pancreas and islet transplantations are performed in a highly selected group of patients with diabetes mellitus, primarily those with type 1 diabetes mellitus, complicated by recurrent severe hypoglycaemia or renal failure requiring kidney transplantation. Clinical accessibility to pancreases or islets, and patient characteristics and t...
Sakr, Mohammad A Reda, Mohga A Ebada, Hend E Abdelmoaty, Ahmed S Hefny, Zeinab M Ibrahim, Zakaria H Aboelmaaty, Mohamed E
Published in
Clinics and research in hepatology and gastroenterology
Behçet's syndrome (BS) is a known cause of Budd-Chiari syndrome (BCS). We aimed at identifying the prevalence of BS in patients with BCS, analyzing different clinical presentations, treatment modalities and outcome of these patients. We conducted a retrospective cohort study, in which all medical records of patients who were presented to Tropical M...
Neuberger, M Sommerer, C Böhnisch, S Metzendorf, N Mehrabi, A Stremmel, W Gotthardt, D Zeier, M Weiss, K H Rupp, C
...
Published in
Clinics and research in hepatology and gastroenterology
Due to the development of immunosuppressants, the focus in transplanted patients has shifted from short-term to long-term survival as well as a better adjustment of these drugs in order to prevent over- and under-immunosuppression. Mycophenolic acid (MPA) is a noncompetitive inhibitor of inosine monophosphate dehydrogenase (IMPDH) and approved for ...
Jiang, Maorong Li, Ran Lyu, Jingjun Li, Xuan Wang, Wei Wang, Zhuoran Sheng, Huaxin Zhang, Weiguo Karhausen, Jörn Yang, Wei
...
Published in
Journal of Neuroinflammation
BackgroundCardiac arrest (CA) is associated with high morbidity and mortality, even after spontaneous circulation is re-established. This dire situation is partly due to post-CA syndrome for which no specific and effective intervention is available. One key component of post-CA syndrome is sterile inflammation, which affects various organs includin...
Modi, Mitul B. Moshiri, Ata S. Shoji, Toru Mihm, Martin C. Jr Xu, Xiaowei Elder, David E.
Published in
Surgical and Experimental Pathology
BackgroundEccrine porocarcinoma is a rare malignancy accounting for 0.005 to 0.01% of all cutaneous tumors. However, its etiology is not well established. Herein we are reporting the occurrence of metastatic porocarcinoma of the back in a patient with a history of multiple cutaneous malignancies and chronic immunosuppression.Case presentationA 79-y...
Rodríguez-Lago, Iago Ramírez de la Piscina, Patricia Elorza, Ainara Merino, Olga Ortiz de Zárate, Jone Cabriada, José Luis
Published in
Gastroenterology
Zanghì, Aurora D'Amico, Emanuele Patti, Francesco
Published in
Expert review of neurotherapeutics
Therapeutic armamentarium in Multiple Sclerosis (MS) has radically changed in the last few decades due to the development of disease modifying treatments (DMTs) with highly selective mechanisms of action. In this review, the authors will focus on the current role of immunosuppressive DMTs in the management of the relapsing-remitting form of MS (RRM...
Dixit, Karan S. Kumthekar, Priya U.
Published in
Current Treatment Options in Oncology
Corticosteroids have been essential in the management of brain tumor patients for decades, primarily for the treatment of peritumoral cerebral edema and its associated neurologic deficits. Dexamethasone is the drug of choice with standard practice being administration up to four times per day, however, because of its long biologic half-life and hig...
