Shiyanbola, Oyewale Nigdelioglu, Recep Dhall, Deepti González, Iván Warmke, Laura Schechter, Shula Choi, Won-Tak Hu, Shaomin Voltaggio, Lysandra Zhang, Yujie
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Ewing sarcoma (ES) is an uncommon mesenchymal neoplasm that typically develops as a bone mass, although up to 30% arise in extraskeletal sites. ES of the gastrointestinal (GI) and hepatobiliary tract is rare and may be misdiagnosed as other, more common neoplasms that occur in these sites. However, the correct classification of extraskeletal ES is ...
Coppard, Valerie Szep, Grisha Georgieva, Zoya Howlett, Sarah K Jarvis, Lorna B Rainbow, Daniel B Suchanek, Ondrej Needham, Edward J Mousa, Hani S Menon, David K
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As the dimensionality, throughput and complexity of cytometry data increases, so does the demand for user-friendly, interactive analysis tools that leverage high-performance machine learning frameworks. Here we introduce FlowAtlas: an interactive web application that enables dimensionality reduction of cytometry data without down-sampling and that ...
Rabadam, Gabrielle Wibrand, Camilla Flynn, Emily Hartoularos, George C Sun, Yang Madubata, Chioma Fragiadakis, Gabriela K Ye, Jimmie Kim, Susan Gartner, Zev J
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Juvenile dermatomyositis (JDM) is one of several childhood-onset autoimmune disorders characterized by a type I IFN response and autoantibodies. Treatment options are limited due to an incomplete understanding of how the disease emerges from dysregulated cell states across the immune system. We therefore investigated the blood of patients with JDM ...
Franco Nitta, Carolina Pierce, Mackenzie Hem, Sopaul Parker, Aiyana Bell, Jordan Huang, Yongyang Patel, Samir Gundimeda, Srinivas Koushik Dings, Justus Shaw, Nicholas
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Published in
Analytical biochemistry
Cell and gene therapy is a fast-growing field for cancer therapeutics requiring reliable instrumentation and technologies. Key parameters essential for satisfying Chemistry Manufacturing and Controls criteria standards are routinely performed using flow cytometry. Recently, image cytometry was developed for cell characterization and cell-based assa...
Rosero, Sara
The immune system employs a “double-edged sword” approach to combat infections: the innate and the adaptive immune responses. The innate immune response provides a rapid, “non-specific” first line of defense, while the adaptive immune response tailors a more targeted response to specific pathogens. B-2 cells are part of the adaptive immune response...
Ogongo, Paul Tran, Anthony Marzan, Florence Gingrich, David Krone, Melissa Aweeka, Francesca Arlehamn, Cecilia S Lindestam Martin, Jeffrey N Deeks, Steven G Hunt, Peter W
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BackgroundInterleukin-17-producing CD4 T cells contribute to the control of Mycobacterium tuberculosis (Mtb) infection in humans; whether infection with human immunodeficiency virus (HIV) disproportionately affects distinct Th17-cell subsets that respond to Mtb is incompletely defined.MethodsWe performed high-definition characterization of circulat...
Chaturvedi, Abhishek Rao, Guruprasad Praharaj, Samir Kumar Guruprasad, Kanive Parashiva Pais, Vivek Sadacharan, Chakravarthy Marx
Published in
Alcohol (Fayetteville, N.Y.)
Chronic alcohol use induces innate immune genes, which activate the innate immune system. Neuroimmune regulatory proteins [e.g., Cluster of Differentiation 200 (CD200)] are immune response regulators and are involved in balancing the immune response. This study aimed to investigate the expression of CD200 on the surface of peripheral blood leukocyt...
Saft, Leonie
Published in
Pathologie (Heidelberg, Germany)
Die Klassifikation gemäß World Health Organization (WHO-HAEM5) und die International Consensus Classification (ICC) myeloischer Neoplasien basieren auf der Integration klinischer, morphologischer, immunphänotypischer und genetischer Daten. Die durchflusszytometrische Immunphänotypisierung (FCIP) ermöglicht die Identifizierung, Auszählung und Charak...
Pereira, Vanessa Ingrid Cardoso de Brito Junior, Lacy Cardoso Falcão, Luiz Fabio Magno da Costa Vasconcelos, Pedro Fernando Quaresma, Juarez Antônio Simões Berg, Ana Virgínia Van Dem Paixão, Ana Paula Silveira Ferreira, Roberta Isabella Senna Diks, Izabela Bezerra Costa
Published in
International immunopharmacology
The present study sought to characterize the pattern of monocyte subpopulations in patients during the course of the infections caused by SARS-CoV-2 virus or who presented long COVID-19 syndrome compared to monocytes from patients with zika virus (Zika) or chikungunya virus (CHIKV). Study with 89 peripheral blood samples from patients, who underwen...
Garman, Bradley Jiang, Can Daouti, Sherif Kumar, Sanah Mehta, Priyanka Jacques, Miye K. Menard, Laurence Manjarrez-Orduno, Nataly Dolfi, Sonia Mukherjee, Piali
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Published in
Frontiers in Immunology
Background Immune cell expression profiling from patient samples is critical for the successful development of immuno-oncology agents and is useful to understand mechanism-of-action, to identify exploratory biomarkers predictive of response, and to guide treatment selection and combination therapy strategies. LAG-3 is an inhibitory immune checkpoin...