Published in Oman Medical Journal
Objectives Acute leukemias (AL) are a heterogeneous group of hematological malignancies with the presence of 20% or more blasts in the peripheral blood or bone marrow. Malignant cells display characteristic patterns of surface antigenic expression. Aberrant phenotypes are defined as patterns of antigen expression on neoplastic cells different from ...
ABSTRACT B-cell prolymphocytic leukemia (B-PLL) is an extremely rare disease, accounting for approximately 1% of the lymphocytic leukemias. B-PLL generally occurs in older people. It is characterized by the presence of more than 55% prolymphocytes in the peripheral blood (PB), no or minimal lymphadenopathy, massive splenomegaly, and very high white...
Published in Acta Cirúrgica Brasileira
Purpose: Comparing survival rates of rats subjected to spleen procedures after fecal peritonitis induction. Assessing changes in TCD4 and CD8 lymphocyte rates before and after the procedures. Correlating animal survival with CD4 and CD8 lymphocytes. Methods: Thirty male Wistar rats were distributed into 3 groups of ten: spleen manipulation (SM); to...
Published in International journal of hematology
Published in Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
NPM1 mutation status and the allelic ratio (AR) of FLT3-internal tandem duplication (FLT3-ITD) are routinely tested for disease risk stratification in patients with normal karyotype (NK) acute myelogenous leukemia (AML); however, the predictive impact of immunophenotypic markers on different NPM1/FLT3 genotypes remains unclear. We performed a retro...
Published in Strahlentherapie Und Onkologie
Background In this exploratory study, the impact of local irradiation on systemic changes in stress and immune parameters was investigated in eight patients treated with intensity-modulated radiation therapy (IMRT) or stereotactic ablative body radiotherapy (SABR) for prostate adenocarcinoma to gain deeper insights into how radiotherapy (RT) modula...
Published in Zhonghua nei ke za zhi
目的： 分析原发性浆细胞白血病（pPCL）免疫分型、细胞遗传学特点，评估硼替佐米及造血干细胞移植（HSCT）疗效及对患者生存的影响。 方法： 对北京大学人民医院1998年1月至2019年3月收治的42例pPCL患者临床资料进行回顾性队列研究。所有患者随访至2019年12月31日。免疫分型及细胞遗传学特点与既往已报道多中心多发性骨髓瘤免疫分型及细胞遗传学特点进行比较，应用卡方检验进行分析。将39例接受治疗患者分为硼替佐米为基础化疗组（29例）及非硼替佐米为基础化疗组（10例），应用卡方检验进行疗效比较，Kaplan-Meier方法进行单因素预后分析，Cox比例风险模型进行多因素分析。将39例患者分为造血干细胞移植组（15例）及未行造血干细胞移植组（24例），应用Kaplan-Meier方法进行...
Multiple myeloma (MM) cell lines are routinely used to model the disease. However, a long-standing question is how well these cell lines truly represent tumor cells in patients. Here, we employ a recently described method of transcriptional correlation profiling to compare similarity of 66 MM cell lines to 779 newly diagnosed MM patient tumors. We ...
Published in Diabetologia
Aims/hypothesis Mucosal-associated invariant T (MAIT) cells are innate-like T cells that recognise derivatives of bacterial riboflavin metabolites presented by MHC-Ib-related protein 1 (MR1) molecules and are important effector cells for mucosal immunity. Their development can be influenced by the intestinal microbiome. Since the development of typ...
Published in Journal of reproductive immunology
Pregnancy represents an immunological challenge for the maternal immune system. Pregnancy augments innate immune responses, and particularly monocytes contribute to maintaining the balance between pro- and anti-inflammatory immune responses required for the successful sequence of distinct immunological phases throughout pregnancy. Nonetheless, stud...
