Fernández-Veiga, Leire Fuertes, Miguel Geijo, María Pérez de Val, Bernat Vidal, Enric Michelet, Lorraine Boschiroli, María Laura Gómez-Buendía, Alberto Bezos, Javier Jones, Gareth
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The single and comparative intradermal tuberculin tests (SITT and CITT) are official in vivo tests for bovine tuberculosis (TB) diagnosis using bovine and avian purified protein derivatives (PPD-B and PPD-A). Infection with bacteria other than Mycobacterium tuberculosis complex (MTC) can result in nonspecific reactions to these tests. We evaluated ...
Smit, Virginia de Mol, Jill Schaftenaar, Frank H Depuydt, Marie A C Postel, Rimke J Smeets, Diede Verheijen, Fenne W M Bogers, Laurens van Duijn, Janine Verwilligen, Robin A F
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Published in
Cardiovascular research
Aging is a dominant driver of atherosclerosis and induces a series of immunological alterations, called immunosenescence. Given the demographic shift towards elderly, elucidating the unknown impact of aging on the immunological landscape in atherosclerosis is highly relevant. While the young Western diet-fed Ldlr-deficient (Ldlr-/-) mouse is a wide...
Presicce, Pietro Cappelletti, Monica Morselli, Marco Ma, Feiyang Senthamaraikannan, Paranthaman Protti, Giulia Nadel, Brian Aryan, Laila Eghbali, Mansoureh Salwinski, Lukasz
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Intrauterine infection/inflammation (IUI) is a frequent complication of pregnancy leading to preterm labor and fetal inflammation. How inflammation is modulated at the maternal-fetal interface is unresolved. We compared transcriptomics of amnion (a fetal tissue in contact with amniotic fluid) in a preterm Rhesus macaque model of IUI induced by lipo...
Kron, Kevin Joshi, Shyam
Published in
BMJ case reports
A female in early childhood presented with 6 months of transient swelling of multiple areas of her body, often, but not always, associated with minor trauma. Labs drawn were significant for low C4, low CH50, low C1 esterase inhibitor (C1-INH) antigen and low C1-INH function, which is concerning for hereditary angioedema (HAE) with abnormal C1-INH. ...
Lam, Brandon Kung, Yu Jui Lin, John Tseng, Ssu-Hsueh Tu, Hsin-Fang Huang, Claire Lee, Brandon Velarde, Esteban Tsai, Ya Chea Villasmil, Rafael
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Published in
The Journal of clinical investigation
Even with the prolific clinical use of next-generation cancer therapeutics, many tumors remain unresponsive or become refractory to therapy, creating a medical need. In cancer, DCs are indispensable to T cell activation, so there is a restriction on cytotoxic T cell immunity if DCs are not present in sufficient numbers in the tumor and draining lym...
Brauge, Baptiste Dessauge, Elise Creusat, Florent Tarte, Karin
Published in
Frontiers in Immunology
B-cell lymphomas are a group of heterogeneous neoplasms resulting from the clonal expansion of mature B cells arrested at various stages of differentiation. Specifically, two lymphoma subtypes arise from germinal centers (GCs), namely follicular lymphoma (FL) and GC B-cell diffuse large B-cell lymphoma (GCB-DLBCL). In addition to recent advances in...
Simón-Fuentes, Miriam Ríos, Israel Herrero, Cristina Lasala, Fátima Labiod, Nuria Luczkowiak, Joanna Roy-Vallejo, Emilia Fernández de Córdoba-Oñate, Sara Delgado-Wicke, Pablo Bustos, Matilde
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Published in
JCI insight
Monocyte-derived macrophages, the major source of pathogenic macrophages in COVID-19, are oppositely instructed by M-CSF or GM-CSF, which promote the generation of anti-inflammatory/immunosuppressive MAFB+ (M-MØ) or pro-inflammatory macrophages (GM-MØ), respectively. The transcriptional profile of prevailing macrophage subsets in severe COVID-19 le...
Sousa-Pinto, Bernardo Vieira, Rafael José Brozek, Jan Cardoso-Fernandes, António Lourenço-Silva, Nuno Ferreira-da-Silva, Renato Ferreira, André Gil-Mata, Sara Bedbrook, Anna Klimek, Ludger
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Published in
BMJ open
Intranasal antihistamines and corticosteroids are some of the most frequently used drug classes in the treatment of allergic rhinitis. However, there is uncertainty as to whether effectiveness differences may exist among different intranasal specific medications. This systematic review aims to analyse and synthesise all evidence from randomised con...
Acencio, Marcio Luis Ostaszewski, Marek Mazein, Alexander Rosenstiel, Philip Aden, Konrad Mishra, Neha Andersen, Vibeke Sidiropoulos, Prodromos Banos, Aggelos Filia, Anastasia
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peer reviewed / Chronic inflammatory diseases (CIDs), including inflammatory bowel disease (IBD), rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are thought to emerge from an impaired complex network of inter- and intracellular biochemical interactions among several proteins and small chemical compounds under strong influence of g...
Low, Eric E Song, Qingyuan Yadlapati, Rena Dellon, Evan S Aceves, Seema Liu, Lin Gupta, Samir Choksi, Yash A Shah, Shailja C
Published in
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Gaps remain in understanding the epidemiology of eosinophilic esophagitis (EoE). Our aim was to identify and validate a national cohort of individuals with EoE using Veterans Health Administration (VHA) data. We used 2 validation strategies to develop algorithms that identified adults with EoE between 1999 and 2020. The first validation strategy ap...
