Dumond, Aurore Brachet, Etienne Durivault, Jérôme Vial, Valérie Puszko, Anna K. Lepelletier, Yves Montemagno, Christopher Pagnuzzi-Boncompagni, Marina Hermine, Olivier Garbay, Christiane
...
Published in
Journal of Experimental & Clinical Cancer Research
BackgroundDespite the improvement of relapse-free survival mediated by anti-angiogenic drugs like sunitinib (Sutent®), or by combinations of anti-angiogenic drugs with immunotherapy, metastatic clear cell Renal Cell Carcinoma (mccRCC) remain incurable. Hence, new relevant treatments are urgently needed. The VEGFs coreceptors, Neuropilins 1, 2 (NRP1...
Tournier, Pierre Guicheux, Jérôme Paré, Arnaud Maltezeanu, Aymeric Blondy, Thibaut Veziers, Joëlle Vignes, Caroline André, Manon Lesoeur, Julie Barbeito, Ana
...
Published in
Scientific Reports
In skeletal surgical procedures, bone regeneration in irregular and hard-to-reach areas may present clinical challenges. In order to overcome the limitations of traditional autologous bone grafts and bone substitutes, an extrudable and easy-to-handle innovative partially demineralized allogenic bone graft in the form of a paste has been developed. ...
Roll, Garrett R Lunow-Luke, Tyler Braun, Hillary J Buenaventura, Owen Mallari, Mirelle Stock, Peter G Rajalingam, Raja
HLA antibodies are typically produced after exposure to transplanted tissue, pregnancy, and blood products. Sensitization delays access to transplantation and preclude utilization of donor organs. Infections and vaccinations have also been reported to result in HLA antibody formation. It is not known if patients develop HLA antibodies after infecti...
Romero, Romina A Klausner, Jeffrey D Marsch, Lisa A Young, Sean D
Since the beginning of the HIV epidemic, there have been more than 75 million cases. Currently, there about 1.2 million living with HIV in the USA. Despite current testing recommendations, test rates continue to be suboptimal. Investigators have studied the use of digital technology to promote HIV testing, especially among high-risk populations. PU...
Franco, Jovany Jeomar Reyes Luis, Jose Luis Rahim, Salma Greenstein, Stephen Pineda, Roberto
Published in
The British journal of ophthalmology
To evaluate and report the outcomes following phacoemulsification on four eyes, 45 years or more after corneal transplantation. A retrospective case series of four eyes in three patients (P1, P2, P3), undergoing phacoemulsification at least 45 years after corneal transplantation by Dr Ramon Castroviejo. Corneal graft survival outcome measures inclu...
Mohammed, Imran Mohanty, Debasmita Said, Dalia G Barik, Manas Ranjan Reddy, Mamatha M Alsaadi, Ahmed Das, Sujata Dua, Harminder Singh Mittal, Ruchi
Published in
The British journal of ophthalmology
Fungal keratitis (FK) is the leading cause of unilateral blindness in the developing world. Antimicrobial peptides (AMPs) have been shown to play an important role on human ocular surface (OS) during bacterial, viral and protozoan infections. In this study, our aim was to profile a spectrum of AMPs in corneal tissue from patients with FK during the...
Sun, Ting He, Yufei Li, Wendong Liu, Guang Li, Lin Wang, Lu Xiao, Zixuan Han, Xiaohan Wen, Hao Liu, Yong
...
Published in
BMC Bioinformatics
BackgroundNeoantigen based personalized immune therapies achieve promising results in melanoma and lung cancer, but few neoantigen based models perform well in IDH wild-type GBM, and the association between neoantigen intrinsic features and prognosis remain unclear in IDH wild-type GBM. We presented a novel neoantigen intrinsic feature-based deep l...
Lind, Nicholas A Rael, Victoria E Pestal, Kathleen Liu, Bo Barton, Gregory M
Many of the ligands for Toll-like receptors (TLRs) are unique to microorganisms, such that receptor activation unequivocally indicates the presence of something foreign. However, a subset of TLRs recognizes nucleic acids, which are present in both the host and foreign microorganisms. This specificity enables broad recognition by virtue of the ubiqu...
Photopoulos, Julianna
Published in
Nature
Neurosurgeon Kevin J. Tracey talks to Nature about controlling inflammation in rheumatoid arthritis by stimulating the vagus nerve.
King, Anthony
Published in
Nature
The body’s immune response to viruses has long been thought to spark autoimmune disease. A virus affecting millions of people could help researchers to finally know for sure.
