How COVID unlocked the power of RNA vaccines
Published in Nature
The technology could revolutionize efforts to immunize against HIV, malaria, influenza and more.
How can countries stretch COVID vaccine supplies? Scientists are divided over dosing strategies
Published in Nature
Researchers worry that efforts to free up limited vaccine doses are driven by desperation rather than data.
A rapid, parasite-dependent cellular response to Dirofilaria immitis in the Mongolian jird (Meriones unguiculatus)
Published in Parasites & Vectors
BackgroundThe Mongolian jird (Meriones unguiculatus) has long been recognized as a permissive host for the filarial parasite Brugia malayi; however, it is nonpermissive to another filarial parasite, canine heartworm (Dirofilaria immitis). By elucidating differences in the early response to infection, we sought to identify mechanisms involved in the...
Anti-migraine agents from an immunological point of view
Published in Journal of Translational Medicine
The new wave of anti-migraine agents is nothing less than a milestone in our battle to manage this devastating disease. However, concerns have recently increased regarding the safety of these drugs. CGRP, while known as a potent vasodilator, is also a key neural and immune modulator. The roles of CGRP in immune determination, have been studied in d...
Gut microbiome in Schizophrenia: Altered functional pathways related to immune modulation and atherosclerotic risk.
Emerging evidence has linked the gut microbiome changes to schizophrenia. However, there has been limited research into the functional pathways by which the gut microbiota contributes to the phenotype of persons with chronic schizophrenia. We characterized the composition and functional potential of the gut microbiota in 48 individuals with chronic...
Development of New Antiproliferative Compound against Human Tumor Cells from the Marine Microalgae Nannochloropsis gadit...
...Published in International journal of molecular sciences
Proteomics is a crucial tool for unravelling the molecular dynamics of essential biological processes, becoming a pivotal technique for basic and applied research. Diverse bioinformatic tools are required to manage and explore the huge amount of information obtained from a single proteomics experiment. Thus, functional annotation and protein-protei...
Preoperative Diagnosis and Indications for Endoscopic Resection of Superficial Esophageal Squamous Cell Carcinoma.
Published in Journal of clinical medicine
Endoscopic resection (ER) is the mainstay of treatment for superficial esophageal squamous cell carcinoma (SESCC) instead of esophagectomy because of its minimal invasiveness and favorable clinical outcomes. Developments in endoscopic submucosal dissection have enabled en bloc resection of SESCCs regardless of size, thus reducing the risk of local ...
Current Knowledge on Graves' Orbitopathy.
Published in Journal of clinical medicine
(1) Background: Graves' orbitopathy (GO) is an autoimmune inflammation of the orbital tissues and the most common extra-thyroid symptom of Graves' disease (GD). Mild cases of GO are often misdiagnosed, which prolongs the diagnostic and therapeutic process, leading to exacerbation of the disease. A severe course of GO may cause permanent vision loss...
Evolution of ocular defects in infant macaques following in utero Zika virus infection.
...Published in JCI insight
Congenital Zika syndrome (CZS) is associated with microcephaly and various neurological, musculoskeletal, and ocular abnormalities, but the long-term pathogenesis and postnatal progression of ocular defects in infants are not well characterized. Rhesus macaques are superior to rodents as models of CZS because they are natural hosts of the virus and...
Refractoriness to drugs in migraine may be the result of developing anti-drug antibodies.
Published in Medical hypotheses
Migraine is a common neurological disease and is listed second among the most disabling health conditions worldwide. Refractory migraine (RM) is a term used to emphasize the unresponsiveness of migraine to various treatment options, encompassing both episodic refractory and chronic refractory migraine. In this paper we discuss various known and pos...
