Dumond, Aurore Brachet, Etienne Durivault, Jérôme Vial, Valérie Puszko, Anna K. Lepelletier, Yves Montemagno, Christopher Pagnuzzi-Boncompagni, Marina Hermine, Olivier Garbay, Christiane
...
Published in
Journal of Experimental & Clinical Cancer Research
BackgroundDespite the improvement of relapse-free survival mediated by anti-angiogenic drugs like sunitinib (Sutent®), or by combinations of anti-angiogenic drugs with immunotherapy, metastatic clear cell Renal Cell Carcinoma (mccRCC) remain incurable. Hence, new relevant treatments are urgently needed. The VEGFs coreceptors, Neuropilins 1, 2 (NRP1...
Tournier, Pierre Guicheux, Jérôme Paré, Arnaud Maltezeanu, Aymeric Blondy, Thibaut Veziers, Joëlle Vignes, Caroline André, Manon Lesoeur, Julie Barbeito, Ana
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Published in
Scientific Reports
In skeletal surgical procedures, bone regeneration in irregular and hard-to-reach areas may present clinical challenges. In order to overcome the limitations of traditional autologous bone grafts and bone substitutes, an extrudable and easy-to-handle innovative partially demineralized allogenic bone graft in the form of a paste has been developed. ...
Pauken, Kristen E Shahid, Osmaan Lagattuta, Kaitlyn A Mahuron, Kelly M Luber, Jacob M Lowe, Margaret M Huang, Linglin Delaney, Conor Long, Jaclyn M Fung, Megan E
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The ability to monitor anti-tumor CD8+ T cell responses in the blood has tremendous therapeutic potential. Here, we used paired single-cell RNA and TCR sequencing to detect and characterize "tumor-matching" (TM) CD8+ T cells in the blood of mice with MC38 tumors or melanoma patients using the TCR as a molecular barcode. TM cells showed increased ac...
Tangye, Stuart G Al-Herz, Waleed Bousfiha, Aziz Cunningham-Rundles, Charlotte Franco, Jose Luis Holland, Steven M Klein, Christoph Morio, Tomohiro Oksenhendler, Eric Picard, Capucine
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The most recent updated classification of inborn errors of immunity/primary immunodeficiencies, compiled by the International Union of Immunological Societies Expert Committee, was published in January 2020. Within days of completing this report, it was already out of date, evidenced by the frequent publication of genetic variants proposed to cause...
Singh, Kunwar Mittal, Sasha Gollapudi, Sumanth Butzmann, Alexandra Kumar, Jyoti Ohgami, Robert S
BackgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), known to be the causative agent of COVID-19, has led to a worldwide pandemic. At presentation, individual clinical laboratory blood values, such as lymphocyte counts or C-reactive protein (CRP) levels, may be abnormal and associated with disease severity. However, combinatorial...
Bosso, Matteo Bozzo, Caterina Prelli Volcic, Meta Kirchhoff, Frank
Published in
STAR protocols
IFI16 is an important player of the host intrinsic immune response. Among others, it has been reported to sense intermediate products of HIV-1 reverse transcription in the cytosol and to sequester the transcription factor Sp1 in the nucleus to attenuate viral gene expression. Here, we present three different methods to reduce IFI16 protein expressi...
Hsieh, Wei-Yuan Williams, Kevin J Su, Baolong Bensinger, Steven J
Published in
STAR protocols
Immune cells, such as macrophages, reprogram their lipid metabolism in response to the activation of pattern recognition receptors (e.g., TLRs, NLRs) and cytokine receptors (e.g., interferons, interleukins). Profiling these changes can be achieved with shotgun mass spectrometry. This protocol provides step-by-step instructions on the generation and...
Aschwanden, Christie
Published in
Nature
Even with vaccination efforts in full force, the theoretical threshold for vanquishing COVID-19 looks to be out of reach.
Getz, Wayne M Salter, Richard Luisa Vissat, Ludovica Horvitz, Nir
BackgroundNo versatile web app exists that allows epidemiologists and managers around the world to comprehensively analyze the impacts of COVID-19 mitigation. The http://covid-webapp.numerusinc.com/ web app presented here fills this gap.MethodsOur web app uses a model that explicitly identifies susceptible, contact, latent, asymptomatic, symptomati...
Galera, Cédric Barbosa, Susana Collet, Ophélie Khalfallah, Olfa Aouizerate, Bruno Sutter-Dalley, Anne-Laure Koehl, Muriel Capuron, Lucile Van der Waerden, Judith Melchior, Maria
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Published in
Biological psychiatry
Recent research suggests that immune dysregulation in pregnancy could be a risk factor for anxiety and depression symptoms in offspring. Whereas animal studies have demonstrated the importance of the link between perinatal cytokines and abnormal behaviors in offspring, human epidemiological studies in this area remain limited. The objectives of the...
