De Jaeghere, Emiel A Tuyaerts, Sandra Van Nuffel, An M T Belmans, Ann Bogaerts, Kris Baiden-Amissah, Regina Lippens, Lien Vuylsteke, Peter Henry, Stéphanie Trinh, Xuan Bich
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Published in
Cancer immunology, immunotherapy : CII
A phase II study (PRIMMO) of patients with pretreated persistent/recurrent/metastatic cervical or endometrial cancer is presented. Patients received an immunomodulatory five-drug cocktail (IDC) consisting of low-dose cyclophosphamide, aspirin, lansoprazole, vitamin D, and curcumin starting 2 weeks before radioimmunotherapy. Pembrolizumab was admini...
Oronsky, Bryan Larson, Christopher Hammond, Terese C Oronsky, Arnold Kesari, Santosh Lybeck, Michelle Reid, Tony R
Published in
Clinical reviews in allergy & immunology
Persistent post-COVID syndrome, also referred to as long COVID, is a pathologic entity, which involves persistent physical, medical, and cognitive sequelae following COVID-19, including persistent immunosuppression as well as pulmonary, cardiac, and vascular fibrosis. Pathologic fibrosis of organs and vasculature leads to increased mortality and se...
Yoshido, Kana Honda, Naoki
なぜ免疫系はウイルスを排除して食べ物を排除しないのか？ --予測符号化に基づく免疫記憶のアップデート--. 京都大学プレスリリース. 2023-01-12. / The immune system discriminates between harmful and harmless antigens based on past experiences; however, the underlying mechanism is largely unknown. From the viewpoint of machine learning, the learning system predicts the observation and updates the prediction based ...
Bendavid, Guillaume Hubeau, Céline Perin, Fabienne Gillard, Alison Nokin, Marie-Julie Carnet, Oriane Gerard, Catherine Noël, Agnès Lefèbvre, Philippe Rocks, Natacha
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peer reviewed / BackgroundAsthma is characterized by morphological modifications of the airways (inflammation and remodelling) and bronchial hyperresponsiveness. Mechanisms linking these two key features of asthma are still poorly understood. ADAM28 (a disintegrin and metalloproteinase 28) might play a role in asthma pathophysiology. ADAM28 exists ...
Appah, Anna Beelen, Charlotte J Kirkby, Don Dong, Winnie Shahid, Aniqa Foley, Brian Mensah, Miriam Ganu, Vincent Puplampu, Peter Amoah, Linda E
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Published in
Viruses
The greatest HIV-1 genetic diversity is found in West/Central Africa due to the pandemic's origins in this region, but this diversity remains understudied. We characterized HIV-1 subtype diversity (from both sub-genomic and full-genome viral sequences), drug resistance and coreceptor usage in 103 predominantly (90%) antiretroviral-naive individuals...
Hsu, Michelle A Okamura, Stephanie M De Magalhaes Filho, C Daniel Bergeron, Daniele M Rodriguez, Ahiram West, Melissa Yadav, Deepak Heim, Roger Fong, Jerry J Garcia-Guzman, Miguel
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Published in
Cancer immunology, immunotherapy : CII
The complex immunosuppressive nature of solid tumor microenvironments poses a significant challenge to generating efficacious and durable anticancer responses. Photoimmunotherapy is a cancer treatment strategy by which an antibody is conjugated with a non-toxic light-activatable dye. Following administration of the conjugate and binding to the targ...
Siddiqui, Shafiuddin Livák, Ferenc
Published in
Methods in molecular biology (Clifton, N.J.)
Recent advances have revolutionized the oldest high-throughput single-cell analytical tool, flow cytometry. Fluorescent analyzers and sorters with up to seven lasers and the potential to detect up to 50 parameters are changing the way flow cytometry is used, but old school practices which are inadequate for new technologies remain alive. This chapt...
Wijstma, Eline Vanhamel, Jef Deblonde, Jessika Nöstlinger, Christiana Noori, Teymur Vuylsteke, Bea Laga, Marie
Belibasakis, Georgios N. Belstrøm, Daniel Eick, Sigrun Gursoy, Ulvi K. Johansson, Anders Könönen, Eija
This narrative review summarizes the collective knowledge on periodontal microbiology, through a historical timeline that highlights the European contribution in the global field. The etiological concepts on periodontal disease culminate to the ecological plaque hypothesis and its dysbiosis-centered interpretation. Reference is made to anerobic mic...
Gysens, Lien Depuydt, Eva Patruno, Marco Haspeslagh, Maarten Spaas, Jan Martens, Ann
Sarcoids are the most common equine skin tumours Although they do not metastasize, they can be locally aggressive and cause significant clinical symptoms in affected horses. Despite being common, very little is known about the host immune response and the biological mechanisms underlying persistence and recurrence of equine sarcoids. The latter ref...
