Published in Lancet (London, England)
HIV-1 infection is associated with an increased frequency of clinical malaria and parasitaemia. This association tends to become more pronounced with advancing immunosuppression, and could have important public-health implications for sub-Saharan Africa.
Published in Lancet (London, England)
This article examines the feasibility of a Ugandan study by James Whitworth and colleagues on the effect of HIV-1 infection and advancing immunosuppression on falciparum parasitemia and clinical malaria. The researchers observed the interaction between malaria and HIV-1 infection in adults with acquired immunity to malaria. Data were collected at t...
Published in Bulletin of the World Health Organization
Reported are the effects of elevated levels of anti-tetanus antibodies on the safety and immune response to Haemophilus influenzae type b polyribosylphosphate (PRP)-tetanus toxoid conjugate (PRP-T) vaccine. A group of Thai infants (n = 177) born to women immunized against tetanus during pregnancy were vaccinated with either a combined diptheria-tet...
Published in AIDS weekly plus
A treatment of interleukin II (IL-2) is being developed as an immune stimulant for HIV-positive individuals who have responded to medication, but have not had their immune system recover. While new antiviral drugs are effective in inhibiting HIV, they have not been shown to restore a patient's damaged immune system. IL-2 therapy will be administere...
Published in British journal of obstetrics and gynaecology
The effect of pregnancy on disease progression and survival in HIV-infected women was investigated through a systematic literature review and meta-analysis of the results of eligible studies. The literature search identified seven studies--all prospective cohort analyses--on this topic published in 1983-96. The summary odds ratios (ORs) for adverse...
Published in The Proceedings of the Nutrition Society
This review examines the implications of the fetal and infant origins of disease hypothesis for developing countries. Additionally, the paper looks beyond the chronic diseases of affluence involving susceptibility to infectious diseases. It is estimated that more than 90% of the 25 million low-birth-weight babies born each year are born in developi...
Published in Developments in biological standardization
During the asymptomatic phase of HIV infection, HIV-specific cytotoxic T lymphocytes (CTL) are believed to play a major role in controlling virus levels. The design of an HIV vaccine requires knowledge about whether protective immunity can ever develop after exposure to the virus and the mechanisms underlying such natural immunity. The authors' res...
Published in Clinical and diagnostic laboratory immunology
Numerous studies in developed countries have revealed a higher prevalence of antibodies to Mycoplasma penetrans in homosexuals infected with HIV than in other HIV-positive and HIV-negative population groups. To confirm whether this association prevails in African countries, a cross-sectional analysis was conducted in Brazzaville, Congo, in 1993-94....
Published in Lancet (London, England)
The impact of iron supplementation and malaria chemoprophylaxis was investigated in a double-blind, placebo-controlled study involving 832 infants born in a malaria-hyperendemic area of Tanzania in 1995. Infants were randomly assigned to receive daily oral iron (2 mg/kg) and weekly Deltaprim (3-125 mg pyrimethamine plus 25 mg dapsone), daily iron p...
Published in The Pediatric infectious disease journal
A prospective study of 458 infants from Kampala, Uganda, who were followed from birth to 48 months of age, documented a reduced risk of malaria in children infected with HIV-1. Included in the analysis were 77 HIV-infected children, 232 seroreverters, 125 HIV-negative children born to uninfected mothers, and 24 children of indeterminate HIV status....
