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Immune induction strategies to enhance responses to PD-1 blockade: lessons from the TONIC trial

Published in Journal for ImmunoTherapy of Cancer

Programmed cell death protein 1 (PD-1) blockade is only effective in a minority of patients, prompting the search for combinatorial therapies that increase responses. Identifying effective combinations requires lengthy testing and so far has shown few successes. To accelerate progress Voorwerk and colleagues (Nat Med. 25(6):920-8, 2019) used an ada...