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Autophagy Impairment through Lysosome Dysfunction by Brucine Induces Immunogenic Cell Death (ICD).

Published in The American journal of Chinese medicine

Autophagy is an important tightly controlled cellular process that regulates cellular homeostasis and is involved in deciding cell fate such as cell survival and death. The role of autophagy in many intracellular signaling pathways explains its interaction with other different types of cell death, including apoptosis and immunogenic cell death (ICD...

AXL Targeting Abrogates Autophagic Flux and Induces Immunogenic Cell Death in Drug-Resistant Cancer Cells.

IntroductionAcquired cancer therapy resistance evolves under selection pressure of immune surveillance and favors mechanisms that promote drug resistance through cell survival and immune evasion. AXL receptor tyrosine kinase is a mediator of cancer cell phenotypic plasticity and suppression of tumor immunity, and AXL expression is associated with d...

Polymer- and lipid-based nanomaterials and conjugates for cancer therapy

During the last few decades, remarkable progress has been made towards the understanding of cancer biology. However, cancer remains a major health concern and the treatment of cancer continues to be very challenging. Current cancer treatment modalities include surgery, radiotherapy, immunotherapy and chemotherapy. A primary limitation of chemothera...

Stress-induced cellular responses in immunogenic cell death: Implications for cancer immunotherapy

Published in Biochemical Pharmacology

Cancer is evading the host's defense mechanisms leading to avoidance of immune destruction. During tumor progression, immune-evading cancer cells arise due to selective pressure from the hypoxic and nutrient-deprived microenvironment. Thus, therapies aiming at re-establishing immune destruction of pathological cells constitute innovating anti-cance...

Biomarkers of immunogenic stress in metastases from melanoma patients: Correlations with the immune infiltrate.

Published in Oncoimmunology

Melanoma is known to be under latent immunosurveillance. Here, we studied four biomarkers of immunogenic cell stress and death (microtubule-associated proteins 1A/1B light chain 3B (MAP-LC3B, best known as LC3B)-positive puncta in the cytoplasm as a sign of autophagy; presence of nuclear HMGB1; phosphorylation of eIF2α; increase in ploidy) in melan...