Dursun, Özer Dinç, Erdem Özer, Ömer Kıroğlu, Şeyma Vatansever, Mustafa Adıgüzel, Ufuk
ABSTRACT The aim of this study was to discuss a case of late-onset Klebsiella oxytoca keratitis after deep anterior lamellar keratoplasty and its treatment. A 21-year-old female patient presented with redness and effluence in the left eye at 5 months after uncomplicated deep anterior lamellar keratoplasty surgery. In the examination, a single sutur...
Huo, Xiaokui Meng, Qiang Wang, Changyuan Wu, Jingjing Zhu, Yanna Sun, Pengyuan Ma, Xiaodong Sun, Huijun Liu, Kexin
Published in
Phytotherapy research : PTR
Imipenem (Imp) is a widely used broad-spectrum antibiotic. However, renal adverse effects limit its clinical application. We previously reported that organic anion transporters (OATs) facilitated the renal transport of Imp and contributed its nephrotoxicity. Natural flavonoids exhibited renal protective effect. Here, we aimed to develop potent OAT ...
Takei, Satomi Ihara, Hiroaki Togo, Shinsaku Nakamura, Ayako Fujimoto, Yuichi Watanabe, Junko Kurokawa, Kana Shibayama, Kohei Sumiyoshi, Issei Ochi, Yusuke
...
Published in
BMC Microbiology
BackgroundNontuberculous mycobacteria (NTM) are ubiquitous organisms and the incidence of NTM infections has been increasing in recent years. Mycobacteroides abscessus (M. abscessus) is one of the most antimicrobial-resistant NTM; however, no reliable antibiotic regimen can be officially advocated. We evaluated the efficacy of clarithromycin in com...
Conceição, Natália Rodrigues, Wellington Francisco de Oliveira, Kessys Lorrânya Peralta da Silva, Lucas Emanuel Pinheiro de Souza, Laís Rezende Cardoso da de Cunha Hueb Barata Oliveira, Cristi... de Oliveira, Adriana Gonçalves
Published in
Annals of Clinical Microbiology and Antimicrobials
This study aimed to evaluate the accuracy of disk diffusion and Etest methods, compared to that of the broth dilution reference method for identifying beta-lactam susceptibilities of Penicillin-Resistant, Ampicillin-Susceptible Enterococcus faecalis (PRASEF) isolates. Fifty-nine PRASEF and 15 Penicillin-Susceptible, Ampicillin-Susceptible E. faecal...
Chalhoub, H Harding, S V Tulkens, P M Van Bambeke, F
Published in
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
Burkholderia pseudomallei, Yersinia pestis and Francisella tularensis are facultative intracellular bacteria causing life-threatening infections. We have (a) compared the activity of finafloxacin (a fluoroquinolone in development showing improved activity at acidic pH) with that of ciprofloxacin, levofloxacin and imipenem against the extracellular ...
Su, Li Tu, Ye Kong, De-Pei Chen, Da-Gui Zhang, Chen-Xi Zhang, Wan-Nian Zhuang, Chun-Lin Wang, Zhi-Bin
Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Coronavirus Disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus -2 (SARS-CoV-2) has been widely spread in the world with a high mortality. Cytokine storm syndrome (CSS) and acute lung injury caused by SARS-CoV-2 infection severely threaten the patients. With the purpose to find effective and low-toxic drugs to mitigate C...
Schmid, Matthias Steiner, Oliver Fasshold, Lisa Goessler, Walter Holl, Anna-Maria Kühn, Klaus-Dieter
Published in
European Journal of Medical Research
BackgroundProsthetic joint infection (PJI) is a serious complication of orthopedic implant surgery. Treatment often includes the use of an antibiotic-loaded Polymethyl methacrylate (PMMA) bone cement spacer. Several antibiotics are commonly used for the preparation of these spacers, but due to the increasing number of infections with resistant Gram...
Soleymanzadeh Moghadam, Somayeh Mohammad, Nazanin Ghooshchian, Maryam FathiZadeh, Sara Khodaii, Zohreh Faramarzi, Mahmood Fagheei Aghmiyuni, Zeinab Roudbari, Masoud Pazouki, Abdolreza Mousavi Shabestari, Tahereh
...
Published in
Medical Journal of the Islamic Republic of Iran
Background: Infection of burn wounds is one of the most important problems in the world. Lactobacillus plantarum is known for burn wound healing because of the immunomodulatory and anti-microbial roles. This study was performed to compare the effects of L. plantarum and imipenem – alone and in combination – on infected burn wound healing. Methods: ...
Kresken, Michael Körber-Irrgang, Barbara Korte-Berwanger, Miriam Pfennigwerth, Niels Gatermann, Sören G Seifert, Harald
Published in
International journal of antimicrobial agents
Pseudomonas aeruginosa (PA) is a major cause of healthcare-associated infections. Antipseudomonal carbapenems are among the antimicrobial agents used to treat PA infections, but several mechanisms of resistance, including the production of a carbapenemase (CP), may compromise their clinical efficacy. The objectives of this study were to determine: ...
Wan, Dapeng Jing, Xiaopeng Zhou, Huan Min, Xiaochun Zhang, Xing Wu, Tingting Liu, Rong Zeng, Ji
Published in
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
The spread of carbapenemase-producing Enterobacteriaceae (CPE) is a major threat to public health. In the present study, we compared the difference between meropenem and imipenem disk for detecting carbapenemase-producing gram-negative bacilli using simplified carbapenem inactivation method (sCIM). 106 Enterobacteriaceae, including 74 CPE, 17 Pseud...