Yu, Zhou Du, Jiaying Hui, Hui Kan, Shaoxin Huo, Tongxin Zhao, Kai Wu, Tao Guo, Qinglong Lu, Na
Published in
Theranostics
Rationale: Acute myeloid leukemia (AML) is a common type of haematological malignancy. Several studies have shown that neoplasia in AML is enhanced by tyrosine kinase pathways. Recently, given that aberrant activation of Fms-like tyrosine receptor kinase 3 (FLT3) acts as a critical survival signal for cancer cells in 20‒30% patients with AML, inhib...
Goel, Nupur Peng, Kang Lu, Yong
Published in
Frontiers in Neural Circuits
The ability of humans and animals to localize the source of a sound in a complex acoustic environment facilitates communication and survival. Two cues are used for sound localization at horizontal planes, interaural time and level differences (ITD and ILD), which are analyzed by distinct neural circuits in the brainstem. Here, we review the studies...
Aralla, Roberta Ashida, Go Köppl, Christine
Published in
The European journal of neuroscience
The auditory midbrain is the location in which neurons represent binaural acoustic information necessary for sound localization. The external nucleus of the midbrain inferior colliculus (IC) of the barn owl is a classic example of an auditory space map, but it is unknown to what extent the principles underlying its formation generalize to other, le...
Köppl, Christine
Published in
The Journal of experimental biology
Interaural time differences (ITDs) are one of several principal cues for localizing sounds. However, ITDs are in the sub-millisecond range for most animals. Because the neural processing of such small ITDs pushes the limit of temporal resolution, the precise ITD range for a given species and its usefulness - relative to other localization cues - ha...
Astolfi, Annalisa Fiore, Michele Melchionda, Fraia Indio, Valentina Bertuccio, Salvatore N Pession, Andrea
Published in
Epigenomics
BCOR is a gene that encodes for an epigenetic regulator involved in the specification of cell differentiation and body structure development and takes part in the noncanonical polycomb repressive complex 1. This review provides a comprehensive summary of BCOR’s involvement in oncology, illustrating that various BCOR aberrations, such as the intern...
Al-Ghabkari, Abdulhameed Perinpanayagam, Maneka A Narendran, Aru
Published in
Current cancer drug targets
GDC-0980 is a selective small molecule inhibitor of class I PI3K and mTOR pathway with a potent anti-proliferative activity. We set out to evaluate the efficacy of GDC-0980, in pre-clinical studies, against pediatric leukemia cells. The anti-neoplastic activity of GDC-0980 was evaluated in vitro using five different pediatric leukemia cells. Our da...
Schillberg, Patrick
This thesis deals with the question, in which way the North American Barn Owl (Tyto furcata pratincola) reacts to sound sources, whose acoustic information is not unambiguously encoded by broadband ITD and broadband ILD. Therefore, in a first experiment impulse responses close to the ear drum of owls were measured at 528 positions. These impulse re...
Bednar, Adam Lalor, Edmund C
Published in
NeuroImage
It is of increasing practical interest to be able to decode the spatial characteristics of an auditory scene from electrophysiological signals. However, the cortical representation of auditory space is not well characterized, and it is unclear how cortical activity reflects the time-varying location of a moving sound. Recently, we demonstrated that...
Marhäll, Alissa Heidel, Florian Fischer, Thomas Rönnstrand, Lars
Published in
Annals of Hematology
Acute myeloid leukemia (AML) remains the most common form of acute leukemia among adults and accounts for a large number of leukemia-related deaths. Mutations in FMS-like tyrosine kinase 3 (FLT3) is one of the most prevalent findings in this heterogeneous disease. The major types of mutations in FLT3 can be categorized as internal tandem duplicatio...
Wang, Fei Zhang, Wenjin Ding, Yu
Published in
Vibroengineering PROCEDIA
Fault diagnosis for bearings is a focus and difficulty in diagnosis research area, so an intelligent diagnosis method using intrinsic time-scale decomposition(ITD) and extreme learning machine (ELM) is proposed in this paper. ITD is a relatively practical non-stationary signal decomposition method, which can decompose non-stationary signal into sev...
