Salihefendić, Lana Čeko, Ivana Bešić, Larisa Mulahuseinović, Naida Durgut, Selma Pećar, Dino Prnjavorac, Lejla Kandić, Enis Meseldžić, Neven Bego, Tamer
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Published in
Frontiers in Genetics
Introduction: COVID-19 has been a major focus of scientific research since early 2020. Due to its societal, economic, and clinical impact worldwide, research efforts aimed, among other questions, to address the effect of host genetics in susceptibility and severity of COVID-19. Methods: We, therefore, performed next-generation sequencing of coding ...
Ma, Wei Huang, Gang Wang, Zhi Wang, Li Gao, Qiangguo
Published in
Frontiers in Immunology
Interferon regulatory factor (IRF) 7 was originally identified as master transcriptional factor that produced IFN-I and regulated innate immune response, subsequent studies have revealed that IRF7 performs a multifaceted and versatile functions in multiple biological processes. In this review, we provide a comprehensive overview on the current know...
Zhang, Can Lu, Long-Feng Li, Zhuo-Cong Han, Ke-Jia Wang, Xue-Li Chen, Dan-Dan Xiong, Feng Li, Xi-Yin Zhou, Li Ge, Feng
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Published in
Journal of Virology
During viral infection, host defensive proteins either enhance the host immune response or antagonize viral components directly. In this study, we report on the following two mechanisms employed by zebrafish mitogen-activated protein kinase kinase 7 (MAP2K7) to protect the host during spring viremia of carp virus (SVCV) infection: stabilization of ...
Qing, Furong Liu, Zhiping
Published in
Frontiers in Immunology
Interferon regulatory factor 7 (IRF7), a member of the interferon regulatory factors (IRFs) family, is located downstream of the pattern recognition receptors (PRRs)-mediated signaling pathway and is essential for the production of type I interferon (IFN-I). Activation of IRF7 inhibits various viral and bacterial infections and suppresses the growt...
Duncan, Joseph K. Sampson Xu, Danyang Licursi, Maria Joyce, Michael A. Saffran, Holly A. Liu, Kaiwen Gohda, Jin Tyrrell, D. Lorne Kawaguchi, Yasushi Hirasawa, Kensuke
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Published in
Frontiers in Immunology
Interferon regulatory factors (IRFs) are key elements of antiviral innate responses that regulate the transcription of interferons (IFNs) and IFN-stimulated genes (ISGs). While the sensitivity of human coronaviruses to IFNs has been characterized, antiviral roles of IRFs during human coronavirus infection are not fully understood. Type I or II IFN ...
Li, Peng Tian Li, Ying Chen, Ying Zhang, Jia Xi Luo, Zi Hao Zhang, Yi Fan Jiang, Jing Wang, Yi Lei Zhang, Zi Ping Jiang, Yong Hua
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Published in
Frontiers in Marine Science
Tumor necrosis factor receptor-associated factors (TRAFs) play vital roles in tumor necrosis factor receptor (TNF-R) and interleukin-1 receptor/Toll-like receptor (IL-1R/TLR) mediated signaling pathway. However, the role that TRAF7 plays in the host immune responses is largely unknown in comparison to the extensive and in-depth research that has be...
Zhang, Jia Xi Li, Ying Tang, Jun Chun Li, Kai Qing Shen, Juan Juan Liu, Chang Jiang, Yong Hua Zhang, Zi Ping Wang, Yi Lei Zou, Peng Fei
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Published in
Frontiers in Immunology
As a TIR domain-containing molecular, sterile α-and armadillo motif-containing protein (SARM) acts as an adaptor in Toll-like receptor (TLR) signaling, and also plays important roles in mediating apoptosis and neuronal injury. In the present study, the ortholog of SARM, named as Lc-SARM, was cloned and identified in large yellow croaker (Larimichth...
Yang, Xiao Ai, Yue Chen, Liang Wang, Chanyuan Liu, Ji Zhang, Jie Li, Jun Wu, Hui Xiao, Jun Chang, Mingxian
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Published in
Frontiers in Immunology
TGF-β-activated kinase-1 (TAK1), tightly related to innate immunity, is phosphorylated and activated by X-linked protein kinase (PRKX) in humans and mammals, which belongs to the c-AMP-dependent protein kinase family. However, the relationship between PRKX and TAK1 remains unknown in teleost. It has been reported in vertebrates for the first time t...
Gao, Li Liu, Rui Luo, Dan Li, Kai Qi, Xiaole Liu, Changjun Zhang, Yanping Cui, Hongyu Wang, Suyan Gao, Yulong
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Published in
Journal of Virology
Type I interferon (IFN) response is the first line of host-based innate immune defense against viral infections. However, viruses have developed multiple strategies to counter host IFN responses, so they may continue infecting hosts via effective replication. Avian reovirus (ARV), an RNA virus, causes viral arthritis or tenosynovitis in chickens. P...
Bono, Cristina Guerrero, Paula Erades, Ana Jordán-Pla, Antonio Yáñez, Alberto Gil, María Luisa
Published in
Stem cells (Dayton, Ohio)
During an infection, hematopoiesis is altered to increase the output of mature myeloid cells to fight off the pathogen. Despite convincing evidence that hematopoietic stem and progenitor cells (HSPCs) can sense pathogens directly, more mechanistic studies are needed to reveal whether pattern recognition receptor (PRR) signaling initiates myeloid de...
