Engineered Circular RNA Sponges Act as miRNA Inhibitors to Attenuate Pressure Overload-Induced Cardiac Hypertrophy
10.1016/j.ymthe.2020.04.006 / MOLECULAR THERAPY / 28 / 6 / 1506-1517
Exon Junction Complex Shapes the Transcriptome by Repressing Recursive Splicing.
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Published in Molecular cell
Recursive splicing (RS) starts by defining an "RS-exon," which is then spliced to the preceding exon, thus creating a recursive 5' splice site (RS-5ss). Previous studies focused on cryptic RS-exons, and now we find that the exon junction complex (EJC) represses RS of hundreds of annotated, mainly constitutive RS-exons. The core EJC factors, and the...
Metagenome analysis of Russian and Georgian Pyophage cocktails and a placebo-controlled safety trial of single phage ver...
Bacteriophage therapy is a commonly used treatment for Staphylococcus aureus infections in countries of the former Soviet Union, using both single phages and phage cocktails. The scarce data available on Eastern phage cocktails prompted an investigation into commercially-available Pyophage cocktails from two different manufacturers used to treat sk...
Four new endemic genera of Rubiaceae (Pavetteae) from Madagascar represent multiple radiations into drylands
The taxonomic positions and phylogenetic relationships of six Pavetteae species endemic to Madagascar were tested with a phylogenetic study of the Afro-Madagascan representatives of the tribe Pavetteae based on sequence data from six markers rps16, trnT-F, petD, accD-psa1, PI and ITS. The six species were resolved into four well-supported and morph...
A synthetic sex ratio distortion system for the control of the human malaria mosquito.
Published in Nature communications
It has been theorized that inducing extreme reproductive sex ratios could be a method to suppress or eliminate pest populations. Limited knowledge about the genetic makeup and mode of action of naturally occurring sex distorters and the prevalence of co-evolving suppressors has hampered their use for control. Here we generate a synthetic sex distor...
Neonatal progeroid variant of Marfan syndrome with congenital lipodystrophy results from mutations at the 3′ end of FBN1...
...Published in European Journal of Medical Genetics
We report a 16-year-old girl with neonatal progeroid features and congenital lipodystrophy who was considered at birth as a possible variant of Wiedemann–Rautenstrauch syndrome. The emergence of additional clinical signs (marfanoid habitus, severe myopia and dilatation of the aortic bulb) lead to consider the diagnosis of the progeroid variant of M...
ConTra v2 : a tool to identify transcription factor binding sites across species, update 2011
Transcription factors are important gene regulators with distinctive roles in development, cell signaling and cell cycling, and they have been associated with many diseases. The ConTra v2 web server allows easy visualization and exploration of predicted transcription factor binding sites in any genomic region surrounding coding or non-coding genes....
Plasticity of animal genome architecture unmasked by rapid evolution of a pelagic tunicate.
...Published in Science (New York, N.Y.)
Genomes of animals as different as sponges and humans show conservation of global architecture. Here we show that multiple genomic features including transposon diversity, developmental gene repertoire, physical gene order, and intron-exon organization are shattered in the tunicate Oikopleura, belonging to the sister group of vertebrates and retain...
Pompe disease in a Brazilian series: clinical and molecular analyses with identification of nine new mutations
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Genzyme Corporation
Pompe disease in a Brazilian series: clinical and molecular analyses with identification of nine new mutations
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Genzyme Corporation
