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Webster, Philip Dawes, Joanna C. Dewchand, Hamlata Takacs, Katalin Iadarola, Barbara Bolt, Bruce J. Caceres, Juan J. Kaczor, Jakub Dharmalingam, Gopuraja Dore, Marian
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Published in
Nature Communications
Evidence implicating cancer drivers can be sparse when limited to clonal events. Here, the authors present a retrovirus driven in vivo lymphomagenesis time course including hundreds of thousands of subclonal mutations and demonstrate the utility of these in mapping the selective forces affecting cancer gene loci, including negatively selected mutat...
Bardelli, Martino; Zarate-Perez, Francisco; Agundez, Leticia; Linden, R Michael; Escalante, Carlos R; Henckaerts, Els; 130609;
UNLABELLED: The life cycle of the human parvovirus adeno-associated virus (AAV) is orchestrated by four Rep proteins. The large Rep proteins, Rep78 and Rep68, are remarkably multifunctional and display a range of biochemical activities, including DNA binding, nicking, and unwinding. Functionally, Rep78 and Rep68 are involved in transcriptional regu...
Musayev, Faik N; Zarate-Perez, Francisco; Bardelli, Martino; Bishop, Clayton; Saniev, Emil F; Linden, R Michael; Henckaerts, Els; 130609; Escalante, Carlos R;
Adeno-associated virus (AAV) nonstructural proteins Rep78 and Rep68 carry out all DNA transactions that regulate the AAV life cycle. They share two multifunctional domains: an N-terminal origin binding/nicking domain (OBD) from the HUH superfamily and a SF3 helicase domain. A short linker of ∼20 amino acids that is critical for oligomerization and ...
Le Saux, Agnès Houdebine, Louis-Marie Jolivet, Geneviève
Published in
Transgenic Research
This paper reports our attempts to characterize transgene integration sites in transgenic mouse lines generated by the microinjection of large (from 30 to 145 kb) pig DNA fragments encompassing a mammary specific gene, the whey acidic protein gene (WAP). Among the various methods used, the thermal asymmetric interlaced (TAIL-) PCR method allowed us...
