Downregulation of Human DAB2IP Gene Expression in Renal Cell Carcinoma Results in Resistance to Ionizing Radiation
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Improved adsorption reactions, kinetics and stability for model and therapeutic proteins immobilised on affinity resins
Protein adsorption on solid state media is important for the industrial affinity chromatography of biotherapeutics and for preparing materials for self-interaction chromatography where fundamental protein solution thermodynamic properties are measured. The adsorption of three model proteins (lysozyme, catalase and BSA) and two antibodies (a monoclo...
An auto-luminescent fluorescent BCG whole blood assay to enable evaluation of paediatric mycobacterial responses using m...
Introduction: Understanding protective human immunity against mycobacteria is critical to developing and evaluating new vaccines against tuberculosis. Children are the most susceptible population to infection, disease, and death from tuberculosis, but also have the strongest evidence of BCG-inducible protection. Limited amounts of blood can be obta...
FTO controls reversible m6Am RNA methylation during snRNA biogenesis
...Published in Nature Chemical Biology
Two different methylation states of the adenosine adjacent to the snRNA cap are found in the biogenesis process of snRNAs, Am and m6Am, whose levels are regulated by FTO and are related to alternative pre-mRNA splicing.
Mussel-Inspired Self-Healing Coatings Based on Polydopamine-Coated Nanocontainers for Corrosion Protection
The mussel-inspired properties of dopamine have attracted immense scientific interest for surface modification of nanoparticles due to the high potential of dopamine functional groups to increase the adhesion of nanoparticles to flat surfaces. Here, we report for the first time a novel type of inhibitor-loaded nanocontainer using polydopamine (PDA)...
Mussel-Inspired Self-Healing Coatings Based on Polydopamine-Coated Nanocontainers for Corrosion Protection
The mussel-inspired properties of dopamine have attracted immense scientific interest for surface modification of nanoparticles due to the high potential of dopamine functional groups to increase the adhesion of nanoparticles to flat surfaces. Here, we report for the first time a novel type of inhibitor-loaded nanocontainer using polydopamine (PDA)...
Light-Activated Nanoparticles Encapsulated with Santalum Album: A Potential Therapeutic Agent for Neurodegenerative Dise...
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Sandela 803 is a cheap representative synthetic santalum essential oil that has therapeutic effects on neurodegenerative diseases. With development of nanotechnology, many types of nanomaterials loaded with fragrances could regulate release rate of aroma. However, most of them rely on destruction of interaction between fragrances and nanocarriers. ...
Improvement of product distribution through enhanced mass transfer in isobutane/butene alkylation
The isobutane/butene alkylation catalyzed by H2SO4 is a liquid/liquid reaction, and the limited solubility of the hydrocarbon in the catalyst inhibits mass transfer, leading to occurrence of side reactions. Amphiphilic surfactant could enhance mass transfer in multiphasic systems. In this study, a series of quaternary ammonium and phosphonium surfa...
Mendelian randomization study of ACLY and cardiovascular disease
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BACKGROUND ATP citrate lyase is an enzyme in the cholesterol–biosynthesis pathway upstream of 3-hydroxy-3-methylglutaryl–coenzyme A reductase (HMGCR), the target of statins. Whether the genetic inhibition of ATP citrate lyase is associated with deleterious outcomes and whether it has the same effect, per unit decrease in the low-density lipoprotein...
Light-Activated Nanoparticles Encapsulated with Santalum Album: A Potential Therapeutic Agent for Neurodegenerative Dise...
...
Sandela 803 is a cheap representative synthetic santalum essential oil that has therapeutic effects on neurodegenerative diseases. With development of nanotechnology, many types of nanomaterials loaded with fragrances could regulate release rate of aroma. However, most of them rely on destruction of interaction between fragrances and nanocarriers. ...
