O'Reilly, Micaela Mironets, Eugene Saltos, Tatiana Crowther, Kallon Collyer, Eileen Bethea, John Tom, Veronica J
Published in
Journal of neurotrauma
Following a severe, high-level spinal cord injury (SCI), plasticity to intraspinal circuits below-injury results in heightened spinal sympathetic reflex activity and detrimentally impacts peripheral organ systems. Such sympathetic hyperreflexia is immediately apparent as an episode of autonomic dysreflexia (AD), a life-threatening condition charact...
Yan, Ji Chang, Xin-Bo Ma, Xiao-Kai Wang, Heng Zhang, Yong Gao, Ke-Zheng Yoshikawa, Hirofumi Wang, Li-Zhen
Published in
Materials (Basel, Switzerland)
Phosphorization of metal oxides/hydoxides to promote electronic conductivity as a promising strategy has attracted enormous attention for improving the electrochemical properties of anode material in lithium ion batteries. For this article, selective phosphorization from NiCo2O4 to NiO/Ni2Co4P3 microspheres was realized as an efficient route to enh...
Hasin, Deborah Walsh, Claire
Published in
Journal of clinical medicine
The landscape of attitudes, legal status and patterns of use of cannabis is rapidly changing in the United States and elsewhere. Therefore, the primary aim of this narrative review is to provide a concise overview of the literature on the comorbidity of cannabis use and cannabis use disorder (CUD) with other substance use and psychiatric disorders,...
O'Brien, William T Symons, Georgia F Bain, Jesse Major, Brendan P Costello, Daniel M Sun, Mujun Kimpton, Joshua S Chen, Zhibin Brady, Rhys D Mychasiuk, Richelle
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Published in
Journal of neurotrauma
It is increasingly reported that a history of concussion may be associated with chronic deleterious consequences. While the pathophysiology that contributes to these consequences is not well understood, neuroinflammation is postulated to be critical. Activation of multiprotein complexes termed inflammasomes, a key component of this inflammatory res...
DeRoo, Elise; Martinod, Kimberly; 110894; Cherpokova, Deya; Fuchs, Tobias; Cifuni, Stephen; Chu, Long; Staudinger, Caleb; Wagner, Denisa D;
PURPOSE: Platelets are known to play an important role in venous thrombogenesis, but their role in thrombus maturation, resolution, and postthrombotic vein wall remodeling is unclear. The purpose of this study was to determine the role that circulating platelets play in the later phases of venous thrombosis. METHODS: We used a murine inferior vena ...
Aguiar, Maíra Stollenwerk, Nico
Published in
Vaccines
There is a growing public health need for effective preventive interventions against dengue, and a safe, effective and affordable dengue vaccine against the four serotypes would be a significant achievement for disease prevention and control. Two tetravalent dengue vaccines, Dengvaxia (CYD-TDV-Sanofi Pasteur) and DENVax (TAK 003-Takeda Pharmaceutic...
Mendez, Melanie E Sebastian, Aimy Murugesh, Deepa K Hum, Nicholas R McCool, Jillian L Hsia, Allison W Christiansen, Blaine A Loots, Gabriela G
Osteoarthritis (OA) is a debilitating and painful disease characterized by the progressive loss of articular cartilage. Post-traumatic osteoarthritis (PTOA) is an injury-induced type of OA that persists in an asymptomatic phase for years before it becomes diagnosed in ~50% of injured individuals. Although PTOA is not classified as an inflammatory d...
Ulrich, A Otero-Núñez, P Wharton, J Swietlik, E Graf, S Morrell, N Wang, D Lawrie, A Wilkins, M Prokopenko, I
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Expression quantitative trait loci (eQTL) can provide a link between disease susceptibility variants discovered by genetic association studies and biology. To date, eQTL mapping studies have been primarily conducted in healthy individuals from population-based cohorts. Genetic effects have been known to be context-specific and vary with changing en...
Won, J.Y. Kim, J. Gao, G. Kim, J. Jang, J. Park, Y.-H. Cho, D.-W.
The clinical therapy for retinal vascular diseases requires repeated intravitreal injections of drugs owing to their short half-life, which imposes health and economic burdens on patients. Therefore, it is necessary to develop an advanced drug delivery system that can prolong the drug activity and minimize secondary complications. In this study, we...
Tona, Risa Lopez, Ivan A Fenollar-Ferrer, Cristina Faridi, Rabia Anselmi, Claudio Khan, Asma A Shahzad, Mohsin Morell, Robert J Gu, Shoujun Hoa, Michael
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Published in
Genes
Human pathogenic variants of TBC1D24 are associated with clinically heterogeneous phenotypes, including recessive nonsyndromic deafness DFNB86, dominant nonsyndromic deafness DFNA65, seizure accompanied by deafness, a variety of isolated seizure phenotypes and DOORS syndrome, characterized by deafness, onychodystrophy, osteodystrophy, intellectual ...
