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Principal cells of the brainstem's interaural sound level detector are temporal differentiators rather than integrators

Franken, Tom P; 73411; Joris, Philip X; 15721; Smith, Philip H;

The brainstem's lateral superior olive (LSO) is thought to be crucial for localizing high-frequency sounds by coding interaural sound level differences (ILD). Its neurons weigh contralateral inhibition against ipsilateral excitation, making their firing rate a function of the azimuthal position of a sound source. Since the very first in vivo record...

In vivo Whole-Cell Recordings Combined with Electron Microscopy Reveal Unexpected Morphological and Physiological Proper...

Franken, Tom P; 73411; Smith, Philip H; Joris, Philip X; 15721;

The lateral nucleus of the trapezoid body (LNTB) is a prominent nucleus in the superior olivary complex in mammals including humans. Its physiology in vivo is poorly understood due to a paucity of recordings. It is thought to provide a glycinergic projection to the medial superior olive (MSO) with an important role in binaural processing and sound ...

The Touch and Zap method for in vivo whole-cell patch recording of intrinsic and visual responses of cortical neurons an...

Schramm, Adrien E Marinazzo, Daniele Gener, Thomas Graham, Lyle J

Published in PloS one

Whole-cell patch recording is an essential tool for quantitatively establishing the biophysics of brain function, particularly in vivo. This method is of particular interest for studying the functional roles of cortical glial cells in the intact brain, which cannot be assessed with extracellular recordings. Nevertheless, a reasonable success rate r...