Proteomics is a crucial tool for unravelling the molecular dynamics of essential biological processes, becoming a pivotal technique for basic and applied research. Diverse bioinformatic tools are required to manage and explore the huge amount of information obtained from a single proteomics experiment. Thus, functional annotation and protein-protei...
BACKGROUND: Vedolizumab was shown to be effective and safe for patients with ulcerative colitis (UC) or Crohn's disease (CD) in the GEMINI phase 3 and long-term safety (LTS) studies. AIM: To report treatment persistence and safety results up to 2 years after enrolment in the vedolizumab extended access programme (XAP) METHODS: Vedolizumab XAP is a ...
Garcia-Leon, Juan Antonio;Garcia-Diaz, Beatriz;Eggermont, Kristel;Caceres-Palomo, Laura;Neyrinck, Katrien; 117228;Madeiro da Costa, Rodrigo; 127614;Davila, Jose Carlos;Baron-Van Evercooren, Anne;Gutierrez, Antonia;Verfaillie, Catherine M; 48658;
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Oligodendrocytes (OLs) are responsible for myelin production and metabolic support of neurons. Defects in OLs are crucial in several neurodegenerative diseases including multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS). This protocol describes a method to generate oligodendrocyte precursor cells (OPCs) from human pluripotent stem cel...
Loftus, Edward V;Feagan, Brian G;Panaccione, Remo;Colombel, Jean-Frederic;Sandborn, William J;Sands, Bruce E;Danese, Silvio;D'Haens, Geert;Rubin, David T;Shafran, Ira;
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BACKGROUND: Vedolizumab, a gut-selective α4 β7 integrin antibody, is approved for moderately to severely active ulcerative colitis (UC) and Crohn's disease (CD). AIM: To report the final results from the vedolizumab GEMINI long-term safety (LTS) study. METHODS: The phase 3, open-label GEMINI LTS study (initiated May 2009) enrolled patients with UC ...
Jongsma, Maria M. E.Winter, Dwight A.Huynh, Hien Q.Norsa, LorenzoHussey, SeamusKolho, Kaija-LeenaBronsky, JiriAssa, AmitCohen, ShlomiLev-Tzion, Raffi
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Infliximab (IFX) is administered intravenously using weight-based dosing (5 mg/kg) in inflammatory bowel disease (IBD) patients. Our hypothesis is that especially young children need a more intensive treatment regimen than the current weight-based dose administration. We aimed to assess IFX pharmacokinetics (PK), based on existing therapeutic drug ...
INTRODUCTION: Long-term outcomes of patients with ulcerative proctitis (UP) have been poorly investigated, since these patients are excluded from participation in randomized controlled clinical trials. OBJECTIVE: The aim of this study was to investigate the prognostic and therapeutic long-term outcomes of patients with UP. METHODS: A retrospective ...
Artemisinin (ART) has been shown to suppress B cell activation and plasma cell formation. However, its effect on splenic marginal zone (MZ) B cells is unknown. Splenic MZ B cells play a critical role in rapidly induced Ab production against blood-borne foreign Ags. Dysfunction of MZ B cells, due to inhibition of its proliferation or displacement of...
Cook, Dana P;Cunha, Joao Paulo Monteiro Carvalho Mori...Martens, Pieter-Jan; 131642;Sassi, Gabriele; 122049;Mancarella, Francesca;Ventriglia, Giuliana;Sebastiani, Guido;Vanherwegen, An-Sofie;Atkinson, Mark A;Van Huynegem, Karolien;
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A combination treatment (CT) of proinsulin and IL-10 orally delivered via genetically modified Lactococcus lactis bacteria combined with low-dose anti-CD3 (aCD3) therapy successfully restores glucose homeostasis in newly diagnosed non-obese diabetic (NOD) mice. Tolerance is accompanied by the accumulation of Foxp3+ regulatory T cells (Tregs) in the...
