Oltean, Teodora-Eugenia Ibanez, Lorena Divert, Tatyana Ysenbaert, Tine Van Eeckhoutte, Hannelore Goossens, Vera Schotsaert, Michael Bracke, Ken Schepens, Bert Maelfait, Jonathan
...
RIPK3 partially protects against disease caused by influenza A virus (IAV) infection in the mouse model. Here, we compared the immune protection of active vaccination with a universal influenza A vaccine candidate based on the matrix protein 2 ectodomain (M2e) and of passive immunization with anti-M2e IgG antibodies in wild type and Ripk3(-/-) mice...
Rønberg, Rasmus Davidsen, Jesper Rømhild Salzer, Helmut J. F. Van Braeckel, Eva Rosenvinge, Flemming Schønning Laursen, Christian B.
Chronic pulmonary aspergillosis (CPA) is a potentially life-threatening fungal lung infection, and recent research suggests CPA to be more common than previously considered. Although CPA mimics other lung diseases including pulmonary cancer, awareness of this disease entity is still sparse. This study aimed to investigate the prevalence of CPA in a...
Yu, Weili Shen, Lijuan Qi, Jinming Hu, Tao
Protein-based subunit vaccines have received great attention due to their high safety and specificity. However, the protein antigens are poorly immunogenic, necessitating the formulation with adjuvants and antigen delivery systems. As a ligand of TLR7/8, loxoribine markedly enhances cellular and humoral immune responses. Mannan, a biocompatible pol...
Yu, Weili Shen, Lijuan Qi, Jinming Hu, Tao
Protein-based subunit vaccines have received great attention due to their high safety and specificity. However, the protein antigens are poorly immunogenic, necessitating the formulation with adjuvants and antigen delivery systems. As a ligand of TLR7/8, loxoribine markedly enhances cellular and humoral immune responses. Mannan, a biocompatible pol...
Ingels, Joline De Cock, Laurenz Mayer, Rupert L Devreker, Pam Weening, Karin Heyns, Kelly Lootens, Nele De Smet, Saskia Brusseel, Marieke De Munter, Stijn
...
Published in
Cytotherapy
Messenger RNA (mRNA) has become a promising tool in therapeutic cancer vaccine strategies. Owing to its flexible design and rapid production, mRNA is an attractive antigen delivery format for cancer vaccines targeting mutated peptides expressed in a tumor-the so-called neoantigens. These neoantigens are rarely shared between patients, and inclusion...
Wahlen, Karin Yan, Hong Welinder, Charlotte Ernberg, Malin Kosek, Eva Mannerkorpi, Kaisa Gerdle, Bjorn Ghafouri, Bijar
Purpose Fibromyalgia (FM) is a complex pain condition, and exercise is considered the first option of treatment. Few studies have examined the effect of exercise on molecular mechanisms in FM. The aim of this study was to analyze the plasma proteome in women with FM and healthy controls (CON) before and after 15 wk of resistance exercise. This stud...
Vandoorn, Elien Parys, Anna Chepkwony, Sharon Chiers, Koen Van Reeth, Kristien
Swadling, L Diniz, MO Schmidt, NM Amin, OE Chandran, A Shaw, E Pade, C Gibbons, JM Le Bert, N Tan, AT
...
Individuals with potential exposure to SARS-CoV-2 do not necessarily develop PCR or antibody positivity, suggesting some may clear sub-clinical infection before seroconversion. T-cells can contribute to the rapid clearance of SARS-CoV-2 and other coronavirus infections1-3. We hypothesised that pre-existing memory T-cell responses, with cross-protec...
Andreakos, Evangelos; Abel, Laurent; Vinh, Donald C; Kaja, Elzbieta; Drolet, Beth A; Zhang, Qian; O'Farrelly, Cliona; Novelli, Giuseppe; Rodriguez-Gallego, Carlos; Haerynck, Filomeen;
...
SARS-CoV-2 infections display tremendous interindividual variability, ranging from asymptomatic infections to life-threatening disease. Inborn errors of, and autoantibodies directed against, type I interferons (IFNs) account for about 20% of critical COVID-19 cases among SARS-CoV-2-infected individuals. By contrast, the genetic and immunological de...
Bastard, Paul Gervais, Adrian Le Voyer, Tom Rosain, Jérémie Philippot, Quentin Manry, Jérémy Michailidis, Eleftherios Hoffmann, Hans-Heinrich Eto, Shohei Garcia-Prat, Marina
...
Published in
Science immunology
Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/mL, in plasma diluted 1 to 10) of IFN-α and/or -ω are found in about 10% of patients with critical COVID-19 pneumonia, but not in subjects with asymptomatic infections. We detect auto-Abs neutralizing 100-fold lower, more physiological, concentrations of IFN-α and/or -ω (...
