Salum, Ghada M Dawood, Reham M Abd El-Meguid, Mai Ibrahim, Noha E Abdel Aziz, Ashraf O El Awady, Mostafa K
Published in
Genes & diseases
In Egypt, Sofosbuvir (SOF) in combination with Dataclasvir (DCV) is the broadly used DAAs with excellent therapeutic profile. This study is designed to explore the relation between IL28B/TLR4 genetic variants and each of the followings; HCC development post SOF/DCV treatment, progression to HCC in naïve patients and SOF/DCV therapy outcome. A total...
Ouladlahsen, Ahd Bensghir, Rajaa Baba, Hanâ Haddaji, Asmaa Abbadi, Islam Zaidane, Imane Badi, Hanan Sodqi, Mustapha Marih, Latifa Wakrim, Lahcen
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Published in
Pathobiology
Background: It has been reported that interferon-λ3 (IFNL3)might influence the pathogenesis and clearance of human papillomavirus (HPV) infection. The impact of IFNL3 single-nucleotide polymorphism (SNP) on HPV infection is currently unknown. The aim of this study was to investigate the association between variants in the IFNL3 region and HPV infec...
Ansari, M Azim Aranday-Cortes, Elihu Ip, Camilla Lc da Silva Filipe, Ana Lau, Siu Hin Bamford, Connor Bonsall, David Trebes, Amy Piazza, Paolo Sreenu, Vattipally
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Published in
eLife
Hepatitis C virus (HCV) is a highly variable pathogen that frequently establishes chronic infection. This genetic variability is affected by the adaptive immune response but the contribution of other host factors is unclear. Here, we examined the role played by interferon lambda-4 (IFN-λ4) on HCV diversity; IFN-λ4 plays a crucial role in spontaneou...
Naggie, Susanna Clement, Meredith Lusk, Sam Osinusi, Anu Himmel, Tiffany Lucas, Joseph E Thompson, Will J Dubois, Laura Moseley, M Arthur Clark, Paul J
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Published in
Proteomics. Clinical applications
In the interferon era of hepatitis C virus (HCV) therapies, genotype/subtype, cirrhosis, prior treatment failure, sex, and race predicted relapse. Our objective is to validate a targeted proteomics platform of 17 peptides to predict sustained virologic response (SVR). Stored plasma from three, open-label, trials of HIV/HCV-coinfected subjects recei...
Le Ngoc, C Tran Thi Thanh, T Tran Thi Lan, P Nguyen Mai, T Nguyen Hoa, T Nghiem My, N Le Van, T Le Manh, H Le Thanh, P Nguyen Van Vinh, C
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Background The highest burden of disease from hepatitis C virus (HCV) is found in Southeast Asia, but our understanding of the epidemiology of infection in many heavily burdened countries is still limited. In particular, there is relatively little data on acute HCV infection, the outcome of which can be influenced by both viral and host genetics wh...
Soh, Benjy Yi-Min Kumar, Rajneesh Ekstrom, Victoria Sze-Min Lin, Clement Yi-Hao Thangaraju, Sobhana D/O Tan, Hwee Huang Chan, Kwai Peng Choong, Lina Hui Lin Teo, Diana Chow, Wan Cheng
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Published in
Singapore Medical Journal
INTRODUCTION To study the prevalence of hepatitis C virus (HCV) infection in blood donor (BD), haemodialysis (HD) and intravenous drug user (IVDU) populations in Singapore and assess the IL28B polymorphism if HCV positive. METHODS The BD population were healthy volunteers, the HD population were patients who were on haemodialysis for at least six m...
Provazzi, Paola Jocelan Scarin Rossi, Livia Maria Gonçalves Carneiro, Bruno Moreira Miura, Valeria Chamas Rosa, Plinio Cesar Rodrigues de Carvalho, Lucas Rodrigues de Andrade, Stephane Tereza Queiroz Fachini, Roberta Maria Grotto, Rejane Maria Tommasini Silva, Giovanni Faria
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Published in
Brazilian Journal of Microbiology
BackgroundHepatitis C virus (HCV) infection is associated with chronic liver disease, resulting in cirrhosis and hepatocellular carcinoma. Approximately 20% of HCV infections are spontaneously resolved. Here, we assessed the hierarchical relevance of host factors contributing to viral clearance.MethodsDNA samples from 40 resolved infections and 40 ...
Jõgeda, Ene-Ly Avi, Radko Pauskar, Merit Kallas, Eveli Karki, Tõnis Des Jarlais, Don Uusküla, Anneli Toompere, Karolin Lutsar, Irja Huik, Kristi
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Published in
Journal of medical virology
We investigated the presence of a single-nucleotide polymorphism designated rs12979860 in the interferon λ4 (IFNλ4) gene among 345 people who inject drugs (PWID) and 495 blood donors to evaluate associations between the rs12979860 genotypes and human immunodeficiency virus/hepatitis C virus (HIV/HCV). The rs12979860 TT genotype was over-represented...
Ali, Qaisar Jamal, Arshad Imran, Muhammad Ullah, Sajjad Kalam, Irfan Ullah, Shafi Waqar, Ahmed B
Published in
Personalized medicine
There is a strong correlation of IL28B rs12979860 genetic variations and gender with spontaneous clearance of hepatitis C virus (HCV) infection. HCV-infected subjects were categorized into HCV spontaneous clearance (SC) group and chronic hepatitis C (CHC) group on the basis of anti-HCV antibodies and HCV RNA level and follow-up of 6 months. 35 subj...
Shoukat, Abid Khan, Mosin S Mudassar, Syed Kawoosa, Zaffar Shah, Altaf H Zargar, Showkat Ali
Published in
Journal of global infectious diseases
In hepatitis C virus (HCV), infection viral and IL28B genotype along with many clinical and biochemical factors can influence response rates to pegylated interferon plus ribavirin (Peg-IFN-a/R) therapy and progression to chronic hepatitis C (CHC). The present study was conducted to determine the effect of biochemical and risk factors on treatment o...
