Ortega-Vázquez, Alberto Sánchez-Badajos, Salvador Ramírez-García, Miguel Ángel Alvarez-Luquín, Diana López-López, Marisol Adalid-Peralta, Laura Virginia Monroy-Jaramillo, Nancy
Published in
Genes
Parkinson's disease (PD) pathophysiology includes mitochondrial dysfunction, neuroinflammation, and aging as its biggest risk factors. Mitochondrial DNA copy number (mtDNA-CN) and telomere length (TL) are biological aging markers with inconclusive results regarding their association with PD. A case-control study was used to measure TL and mtDNA-CN ...
Lee, Woo-Sung Nam, Kyung-Ho Kim, Jong Hoon Kim, Won-Ju Kim, Jeong Eun Shin, Eui-Cheol Kim, Gil-Ran Choi, Je-Min
Published in
Frontiers in Immunology
Psoriasis is a chronic inflammatory skin disease characterized by hyperplasia of keratinocytes and immune cell infiltration. The IL-17-producing T cells play a key role in psoriasis pathogenesis, while regulatory T (Treg) cells are diminished during psoriatic inflammation. Current psoriasis treatments largely focus on IL-17 and IL-23, however, few ...
Akhtar, Marjahan Basher, Salima Raiyan Nizam, Nuder Nower Hossain, Lazina Bhuiyan, Taufiqur Rahman Qadri, Firdausi Lundgren, Anna
Published in
Frontiers in Immunology
Background Infection with enterotoxigenic Escherichia coli (ETEC) gives rise to IgA antibodies against both the heat labile toxin (LT) and colonization factors (CFs), which are considered to synergistically protect against ETEC diarrhea. Since the development of ETEC-specific long lived plasma cells and memory B cells is likely to be dependent on T...
Cui, Tracy X. Brady, Alexander E. Zhang, Ying-Jian Anderson, Chase Popova, Antonia P.
Published in
Frontiers in Immunology
Bronchopulmonary dysplasia (BPD) is a chronic lung disease in preterm birth survivors characterized by inflammation, impaired alveolarization and dysmorphic vasculature. Activated IL-17A+ lymphocytes are key drivers of inflammation in preterm infants. We have shown that in immature mice chronic airway exposure to lipopolysaccharide (LPS) induces pu...
Zimmermann, Julian Nitsch, Louisa Krauthausen, Marius Müller, Marcus
Published in
Neuromolecular medicine
Interleukin-17A plays a crucial role in multiple sclerosis and other autoimmune diseases. Although the link between IL-17 and disease activity has been clearly demonstrated, the precise function of this cytokine remains elusive. Here, we investigated the function of astrocyte-targeted IL-17A production in GF/IL-17 transgenic mice during EAE. In par...
Khalid, Freeha Takagi, Kiyoshi Sato, Ai Yamaguchi, Mio Guestini, Fouzia Miki, Yasuhiro Miyashita, Minoru Hirakawa, Hisashi Ohi, Yasuyo Rai, Yoshiaki
...
Published in
Breast cancer (Tokyo, Japan)
Triple-negative breast cancer (TNBC) is characterized as highly immunogenic and lacks specific targeted therapies. Interleukin 17A (IL-17A) is a controversial cytokine and is known to have anti-tumor and pro-tumor roles depending on the tumor microenvironment. In addition, IL-17A has been recently implicated in the recruitments of neutrophil into t...
Wu, Haotian Wang, Zhiyuan Li, Xia Chen, Xiaohong Li, Yue Huang, Weiqiang Chang, Lihong Zhang, Gehua
Published in
International forum of allergy & rhinology
Eosinophilic chronic rhinosinusitis (ECRS) is predominantly characterized by nasal type 2 inflammation. The pathogenesis of this condition is complex. High levels of IL-17A are associated with eosinophil infiltration in some inflammatory diseases and contribute to the severity and insensitivity of corticosteroid therapy for chronic rhinosinusitis. ...
Navarro-Compán, Victoria Puig, Luis Vidal, Silvia Ramírez, Julio Llamas-Velasco, Mar Fernández-Carballido, Cristina Almodóvar, Raquel Pinto, José Antonio Galíndez-Aguirregoikoa, Eva Zarco, Pedro
...
Published in
Frontiers in Immunology
Interleukin-17 family (IL-17s) comprises six structurally related members (IL-17A to IL-17F); sequence homology is highest between IL-17A and IL-17F, displaying certain overlapping functions. In general, IL-17A and IL-17F play important roles in chronic inflammation and autoimmunity, controlling bacterial and fungal infections, and signaling mainly...
Lin, Yawen Zhu, Xiaofeng Li, Yiwen Dou, Yue Wang, Jing Qi, Ruiqun Ma, Lei
Published in
Clinical and experimental immunology
(IL)-17A, the effective factor of Th17 cells, acts an important pathological role in the pathogenesis of psoriasis. Notch1/hairy and split 1 (Hes1) and PI3K/AKT signaling pathways are interpenetrated and involved in Th17 cell differentiation and IL-17A production. In this present study, we used imiquimod (IMQ)-induced mouse psoriatic skin inflammat...
Wan, Jian Zhang, Qian Hao, Yilong Tao, Zhang Song, Wei Chen, Song Qin, Long Song, Weidong Shan, Yi
Published in
Frontiers in Cellular and Infection Microbiology
Introduction Sepsis is a common but serious disease in intensive care units, which may induce multiple organ dysfunctions such as liver injury. Previous studies have demonstrated that gamma delta (γδ) T cells play a protective role in sepsis. However, the function and mechanism of γδ T cells in sepsis-induced liver injury have not been fully elucid...
