sooranahalli, chandana rao, vidhya r. zelman, brandon shekhar, mallika keceli, sevnur komurlu bouchard, charles iqbal, omer
Background/Objectives: Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis (SJS/TEN) are rare but severe skin conditions, often triggered by medications, that can be life-threatening. These conditions frequently affect the eyes, causing ocular surface disease, which can result in visual impairment or blindness. Although the exact mechanisms beh...
hou, shaw-min yang, chun-ming huang, wei-chieh cheng, ssu-wei yen, ting-lin hsia, chih-wei hsieh, cheng-ying hsia, chih-hsuan
Inflammation, a fundamental response to infection and injury, involves interactions among immune cells and signaling molecules. Dysregulated inflammation contributes to diseases such as autoimmune disorders and cancer. Interleukin-1 beta (IL-1β), produced by macrophages in response to lipoteichoic acid (LTA) from Gram-positive bacteria, is a key in...
galasso, linda termite, fabrizio mignini, irene esposto, giorgio borriello, raffaele vitale, federica nicoletti, alberto paratore, mattia ainora, maria elena gasbarrini, antonio
...
Fusobacterium nucleatum, a gram-negative anaerobic bacterium, has emerged as a significant player in colorectal cancer (CRC) pathogenesis. The bacterium causes a persistent inflammatory reaction in the colorectal mucosa by stimulating the release of pro-inflammatory cytokines like IL-1β, IL-6, and TNF-α, creating an environment conducive to cancer ...
sikorska-szaflik, hanna dębińska, anna połomska, joanna drabik-chamerska, anna sozańska, barbara
Allergic diseases commonly coexist, manifesting in a sequence described as the “allergic march”. Background/Objectives: This study aimed to evaluate TSLP’s and IL-1β’s potential as biomarkers in both single and multi-pediatric atopic diseases like atopic eczema, food allergy, and anaphylaxis and analyze specific SNPs in the TSLP and IL-1β genes to ...
tsilioni, irene kempuraj, duraisamy theoharides, theoharis c.
Neuroinflammation is involved in various neurological and neurodegenerative disorders in which the activation of microglia is one of the key factors. In this study, we examined the anti-inflammatory effects of the flavonoids nobiletin (5,6,7,8,3′,4′-hexamethoxyflavone) and eriodictyol (3′,4′,5,7-tetraxydroxyflavanone) on human microglia cell line a...
Huang, Caoxin Zhang, Xiaofang Wu, Menghua Yang, Chen Ge, Xilin Chen, Wenting Li, Xuejun Liu, Suhuan Yang, Shuyu
Published in
International immunopharmacology
Retinal pericytes are mural cells surrounding capillaries to maintain the integrity of blood-retina barrier and regulate vascular behaviors. Pericyte loss has been considered as the hallmark of diabetic retinopathy (DR), which is a major complication of diabetes and the leading cause of blindness in adults. However, the precise function of pericyte...
Song, Lei Tai, Yi Li, Jia Xuan Cao, Shen Han, Jing Liu, Xin Zhe Cao, Sheng Li, Ming Yue Zuo, Hong Xiang Xing, Yue
...
Published in
International immunopharmacology
Rubia cordifolia L. has been formally included in the Chinese Pharmacopoeia and utilized for centuries as a traditional Chinese medicine. Mollugin, a quinone compound, is a major active compound extracted from Rubia cordifolia L. Mollugin was reported has multiple pharmacological activity, including anti-inflammatory, anti-tumor effects. However, t...
Tian, Yinghan Li, Zhenkuo Zhang, Yun Tang, Pei Zhuang, Yu Liu, Lewei Fan, Haojie Yao, Xianhu Li, Wenzheng Xia, Lei
...
Published in
Frontiers in Psychiatry
Background Previous evidence suggests that immune-inflammatory dysfunction plays an important role in metabolic disorder (MD) of patients with schizophrenia, yet studies on sex differences in the association between both are limited. The current study aimed to investigate sex differences in the association between MD and inflammatory cytokines in H...
platt, nick shepherd, dawn smith, david a. smith, claire wallom, kerri-lee luqmani, raashid churchill, grant c. galione, antony platt, frances m.
Sandhoff disease (SD) is a progressive neurodegenerative lysosomal storage disorder characterized by GM2 ganglioside accumulation as a result of mutations in the HEXB gene, which encodes the β-subunit of the enzyme β-hexosaminidase. Lysosomal storage of GM2 triggers inflammation in the CNS and periphery. The NLRP3 inflammasome is an important coord...
Meier, Daniel T de Paula Souza, Joyce Donath, Marc Y
Published in
Diabetologia
Increased activity of the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome-IL-1β pathway is observed in obesity and contributes to the development of type 2 diabetes and its complications. In this review, we describe the pathological activation of IL-1β by metabolic stress, ageing and the microbiome and present data on the role ...