Wang, Yang Zhang, Yu Ouyang, Jing Yi, Hanying Wang, Shiyu Liu, Dongbo Dai, Yingying Song, Kun Pei, Wenwu Hong, Ziyang
...
Published in
Cellular oncology (Dordrecht)
TRPV1 is a nonselective Ca2+ channel protein that is widely expressed and plays an important role during the occurrence and development of many cancers. Activation of TRPV1 channels can affect tumour progression by regulating proliferation, apoptosis and migration. Some studies have also shown that activating TRPV1 can affect tumour progression by ...
Zhang, Rong Li, Lulu Yu, Junyan
Published in
Open Life Sciences
Lung cancer (LC) is regarded as a fatal cancer, and insulin-like growth factor 1 (IGF1) and its receptor (IGF1R) have been found to play a key role in regulating tumor glycolytic metabolism. The aim of this study is to investigate LC proliferation regulated by metabolite-mediated IGF1R lactylation. IGF1R was highly expressed in LC tissues and cells...
Pellegrino, Marsha Secli, Valerio D’Amico, Silvia Petrilli, Lucia Lisa Caforio, Matteo Folgiero, Valentina Tumino, Nicola Vacca, Paola Vinci, Maria Fruci, Doriana
...
Published in
Frontiers in Immunology
Cancer immunotherapy has made impressive advances in improving the outcome of patients affected by malignant diseases. Nonetheless, some limitations still need to be tackled to more efficiently and safely treat patients, in particular for those affected by solid tumors. One of the limitations is related to the immunosuppressive tumor microenvironme...
Zhong, Xiaohuan Wang, Huixin
Published in
Journal of periodontal research
The aim of this study was to explore the mechanism underlying periodontal ligament cells (PDLCs) osteogenic differentiation. Periodontitis causes damage to tooth-supporting apparatus and eventually leads to tooth loss. PDLCs hold great promise in periodontal regeneration due to their osteogenic features. The expression of osteogenic markers, lncRNA...
Ludwig, Megan Michmerhuizen, Nicole Wang, Jiayu Birkeland, Andrew Majchrowski, Behirda Nimmagadda, Sai Zhai, Jingyi Bhangale, Apurva Kulkarni, Aditi Jiang, Hui
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BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) is a debilitating disease with poor survival rates. While the epidermal growth factor receptor (EGFR)-targeting antibody Cetuximab is approved for treatment, responses are limited and the molecular mechanisms driving resistance remain incompletely understood. METHODS: To better understand ho...
Park, Sangjung Jin, Hyun-Seok
Published in
Genes & genomics
Unimpaired kidney function is important for maintaining a healthy state of homeostasis in the body. A genome-wide association study (GWAS) conducted on kidney function-associated traits and novel loci of Japanese subjects found that insulin-like-growth factor 1 receptor (IGF1R) gene variants associated with replication were responsible for all thre...
Ludwig, Megan L Michmerhuizen, Nicole L Wang, Jiayu Birkeland, Andrew C Majchrowski, Behirda K Nimmagadda, Sai Zhai, Jingyi Bhangale, Apurva Kulkarni, Aditi Jiang, Hui
...
Published in
Archives of oral biology
Head and neck squamous cell carcinoma (HNSCC) is a debilitating disease with poor survival rates. While the epidermal growth factor receptor (EGFR)-targeting antibody Cetuximab is approved for treatment, responses are limited and the molecular mechanisms driving resistance remain incompletely understood. To better understand how cells survive witho...
Kieser, Quinten J Granoski, Madison J McClelland, Ryley D Griffiths, Cameron Bilawchuk, Leanne M Stojic, Aleksandra Elawar, Farah Jamieson, Kyla Proud, David Marchant, David J
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Published in
The Journal of general virology
RSV is the leading cause of infant hospitalizations and a significant cause of paediatric and geriatric morbidity worldwide. Recently, we reported that insulin-like growth factor 1 receptor (IGF1R) was a receptor for respiratory syncytial virus (RSV) in airway epithelial cells and that activation of IGF1R recruited the coreceptor, nucleolin (NCL), ...
Paganoni, Alyssa J J Cannarella, Rossella Oleari, Roberto Amoruso, Federica Antal, Renata Ruzza, Marco Olivieri, Chiara Condorelli, Rosita A La Vignera, Sandro Tolaj, Fationa
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Published in
International journal of molecular sciences
Gonadotropin-releasing hormone (GnRH) neurons are key neuroendocrine cells in the brain as they control reproduction by regulating hypothalamic-pituitary-gonadal axis function. In this context, anti-Müllerian hormone (AMH), growth hormone (GH), and insulin-like growth factor 1 (IGF1) were shown to improve GnRH neuron migration and function in vitro...
Kaya, Murat Suer, Ilknur Ozgur, Emre Capik, Ozel Karatas, Omer Faruk Ozturk, Sukru Gezer, Ugur Palanduz, Sukru Cefle, Kivanc
Published in
Turkish Journal of Biochemistry
Objectives Multiple myeloma (MM) is a common hematological cancer. Hence, it is important to conduct further studies investigating the molecular mechanisms in detail that contributes to myeloma genesis. In addition to genetic changes, epigenetic factors such as miRNAs may influence the expression of myeloma-related genes. Methods Our study aimed to...
