Fettucciari, Katia Fruganti, Alessandro Marchegiani, Andrea Brancorsini, Stefano Marconi, Pierfrancesco Bassotti, Gabrio
Published in
Journal of Inflammation Research
Clostridioides difficile infection (CDI) has a serious impact on the healthcare system, and most of its pathogenic effects are mainly due to the activity of toxins A and B (TcdA and TcdB, respectively). The molecular mechanisms of their cytotoxic activity are well known, especially in the colon, where the infection occurs and normally remains local...
Pal, Sukumar Ausar, Salvador Fernando Tifrea, Delia F Cheng, Chunmei Gallichan, Scott Sanchez, Violette de la Maza, Luis M Visan, Lucian
Chlamydia trachomatis is the most common bacterial sexually-transmitted pathogen for which there is no vaccine. We previously demonstrated that the degree of phosphate substitution in an aluminum hydroxide adjuvant in a TLR-4-based C. trachomatis serovar E (Ser E) recombinant major outer membrane protein (rMOMP) formulation had an impact on the ind...
Sa, Qila Mercier, Corinne Cesbron-Delauw, Marie-France Suzuki, Yasuhiro
Published in
Microbes and infection
We examined activities of dense granule proteins (GRAs), which Toxoplasma gondii secretes within infected cells, to stimulate microglial IFN-γ production in vitro. We identified that the N-terminal region (amino acids 41-152) of GRA6 (GRA6Nt) stimulates IFN-γ production by both a microglia cell line and primary microglia purified from the brains of...
Sjaastad, Frances V. Kucaba, Tamara A. Dileepan, Thamotharampillai Swanson, Whitney Dail, Cody Cabrera-Perez, Javier Murphy, Katherine A. Badovinac, Vladimir P. Griffith, Thomas S.
Published in
Frontiers in Immunology
Patients who survive sepsis display prolonged immune dysfunction and heightened risk of secondary infection. CD4 T cells support a variety of cells required for protective immunity, and perturbations to the CD4 T cell compartment can decrease overall immune system fitness. Using the cecal ligation and puncture (CLP) mouse model of sepsis, we invest...
He, Zongsheng; Khatib, Abdel-Majid; Creemers, John WM; 17572;
Immunotherapeutic interventions have become an important treatment for various cancer types including triple negative breast cancer (TNBC). Previous studies have shown that T cell-specific Furin deficient mice show regulatory CD4+ T cells (Tregs) malfunction phenotypes due to impaired cleavage of proTGF-β1. However, it is unknown how this phenotype...
Mezouar, Soraya Mege, Jean-Louis
Published in
Journal of leukocyte biology
IFN-γ plays a critical role in the immune response to bacterial infections. It is established that IFN-γ is mainly produced by NK/ILC1 cells and T cells, and most of papers have rejected the biologic reality of alternative sources for more than 20 years. Here, we are proposing to revisit this dogma and discuss the role of macrophage-derived IFN-γ i...
Hoffmann, Delia; 130902; Pilotte, Luc; Stroobant, Vincent; Van den Eynde, Benoit;
Tumor-associated macrophages are immune cells with diverse functions in tumor development. Among other functions, they downregulate immune-mediated tumor rejection by depriving lymphocytes of nutrients. The essential amino acid tryptophan is metabolized by the enzymes indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase (TDO). Indoleamine 2...
Hoffmann, Delia Pilotte, Luc Stroobant, Vincent Van den Eynde, Benoit J
Published in
International Journal of Tryptophan Research : IJTR
Tumor-associated macrophages are immune cells with diverse functions in tumor development. Among other functions, they downregulate immune-mediated tumor rejection by depriving lymphocytes of nutrients. The essential amino acid tryptophan is metabolized by the enzymes indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase (TDO). Indoleamine 2...
Subauste, Carlos S.
Published in
Frontiers in Cellular and Infection Microbiology
Survival of Toxoplasma gondii within host cells depends on its ability of reside in a vacuole that avoids lysosomal degradation and enables parasite replication. The interplay between immune-mediated responses that lead to either autophagy-driven lysosomal degradation or disruption of the vacuole and the strategies used by the parasite to avoid the...
Ivanova, Daria L. Denton, Stephen L. Fettel, Kevin D. Sondgeroth, Kerry S. Munoz Gutierrez, Juan Bangoura, Berit Dunay, Ildiko R. Gigley, Jason P.
Published in
Frontiers in Immunology
Apicomplexans are a diverse and complex group of protozoan pathogens including Toxoplasma gondii, Plasmodium spp., Cryptosporidium spp., Eimeria spp., and Babesia spp. They infect a wide variety of hosts and are a major health threat to humans and other animals. Innate immunity provides early control and also regulates the development of adaptive i...
