Shao, Chunyan Zhu, Chenwen Zhu, Yun Hao, Jiqing Li, Yongxiang Hu, Huaqing Si, Li Zhong, Fei Wang, Xuefu Wang, Hua
...
Published in
Cell & Bioscience
Mucosal-associated invariant T (MAIT) cells are an invariant T cell subset, which have been reported to play an antimicrobial role in infectious diseases. However, little is known about it in malignant diseases and tumors, especially in gastric cancer (GC). So in this study, we aim to examine the frequency, phenotype, partial functional capacity an...
Ouyang, Yan Zhong, Xiaoming Liao, Hongqun Zhu, Pengcheng Luo, Kaiyuan Zhu, Huifang
Published in
SLAS discovery : advancing life sciences R & D
Interferon-γ (IFN-γ) is a critical cytokine in the defense against viral and bacterial infection. It is mainly produced by natural killer cells and activated T cells. Given its regulatory role in coordinating cellular and humoral immune responses, IFN-γ is considered to be an effective therapeutic agent in the treatment of viral infection. Here we ...
Pakravan, Nafiseh Abbasi, Ardeshir Basirat, Erfan Dehghan, Danial Heydari Havadaragh, Sanaz
Published in
International immunopharmacology
The brain has special importance and is known as immune privileged site to and from which trafficking of immune cells is tightly regulated. However, in Alzheimer's disease (AD) the balance of the immune system is disturbed and damages the brain. Given the anatomical and immunological barriers in the brain, we attempted to evaluate if the neuroinfla...
Hotsuki, Yu Sato, Yu Yoshihisa, Akiomi Watanabe, Koichiro Kimishima, Yusuke Kiko, Takatoyo Yokokawa, Tetsuro Misaka, Tomofumi Sato, Takamasa Kaneshiro, Takashi
...
Published in
Journal of clinical medicine
The Glasgow-Blatchford Score (GBS) is one of the most widely used scoring systems for predicting clinical outcomes for gastrointestinal bleeding (GIB). However, the clinical significance of the GBS in predicting GIB in patients with heart failure (HF) remains unclear. We conducted a prospective observational study in which we collected the clinical...
Zhang, Jinqiang He, Hui Qiao, Yan Zhou, Tao He, Haili Yi, Saini Zhang, Lijuan Mo, Li Li, Yahui Jiang, Weike
...
Published in
Glia
Neuroinflammation driven by interferon-gamma (IFN-γ) and microglial activation has been linked to neurological disease. However, the effects of IFN-γ-activated microglia on hippocampal neurogenesis and behavior are unclear. In the present study, IFN-γ was administered to mice via intracerebroventricular injection. Mice received intraperitoneal inje...
De Berardis, Domenico Olivieri, Luigi Rapini, Gabriella Serroni, Nicola Fornaro, Michele Valchera, Alessandro Carano, Alessandro Vellante, Federica Bustini, Massimiliano Serafini, Gianluca
...
Published in
Brain sciences
This study aimed to evaluate the potential relationships between religious coping, hopelessness, and suicide ideation in adult outpatients with the first episode of major depressive disorder (MDD). Ninety-four adult outpatients with MDD were assessed through the Hamilton Depression Rating Scale (HAM-D), the Beck Hopelessness Scale (BHS), and the Sc...
Opejin, Adeleye Surnov, Alexey Misulovin, Ziva Pherson, Michelle Gross, Cindy Iberg, Courtney A Fallahee, Ian Bourque, Jessica Dorsett, Dale Hawiger, Daniel
...
Published in
Cell reports
Various processes induce and maintain immune tolerance, but effector T cells still arise under minimal perturbations of homeostasis through unclear mechanisms. We report that, contrary to the model postulating primarily tolerogenic mechanisms initiated under homeostatic conditions, effector programming is an integral part of T cell fate determinati...
Hu, Xin Shang, Xiaoqian Wang, Liang Fan, Jiahui Wang, Yue Lv, Jie Nazierhan, Shaxika Wang, Hao Wang, Jing Ma, Xiumin
...
Published in
BMC Immunology
AimBrucellar spondylitis (BS) is one of the most serious complications of brucellosis. CXCR3 is closely related to the severity of disease infection. This research aimed to study the degree of BS inflammatory damage through analyzing the expression levels of CXCR3 and its ligands (CXCL9 and CXCL10) in patients with BS.MethodsA total of 29 BS patien...
Patil, Rahul Arvindekar, Akalpita
Published in
Microbial pathogenesis
Diabetes and obesity is associated with change in the gut microbiota, however, the reason for such transition is still unknown. The secondary complications in diabetes mainly stem from protein glycation, oxidative stress and inflammatory response. It is intended to study the correlation between gut proteins glycation and microbial dysbiosis and the...
Dong, Mengya Zhang, Yan Xu, Chenbo Wang, Chen Liu, Mengping Zhang, Zhanyi Wu, Haoyu Yuan, Zuyi Zhou, Juan
Published in
Biotechnology and applied biochemistry
The effects of interferon-γ (IFN-γ) on cholesterol accumulation and the development of foam cells are still unclear. In the present study, we found that IFN-γ promoted liver X receptor (LXR)-α degradation through the ubiquitin-proteasome system in macrophages. The process was dependent on its interactions with phosphorylated signal transducer and a...
