Search Hypoxia response... as keywords on MyScienceWork's publications...

Background The hypoxia-inducible factor-1 HIF-1 signaling pathway is an important topic in high-altitude medicine Network analysis is a novel method for integrating information on different aspects and levels of biological networks However this method has not been used in research on the HIF-1 signaling pathway network To introduce this method into HIF-1-related research fields and verify its feasibility and effectiveness we used a network analytical method to explore the structural attributes of the HIF-1 signaling pathway network Methods First we analyzed the overall network of the HIF-1 signaling pathway using information retrieved from the Kyoto Encyclopedia of Genes and Genomes KEGG We performed topology analysis centrality analysis and subgroup analysis of the network Then we analyzed the core network based on the overall network analysis We analyzed the properties of the topology the bow-tie structure and the structural complexity of the core network Results We obtained topological structure diagrams and quantitative indicators of the overall and core networks of the HIF-1 signaling pathway For the structure diagrams we generated topology diagrams of the network and the bow-tie structure of the core network As quantitative indicators we identified topology centrality subgroups the bow-tie structure and structural complexity The topology indicators were the number of nodes the number of lines the network diameter and the network density The centrality indicators were the degree closeness and betweenness The cohesive subgroup indicator was the components of the network The bow-tie structure indicators included the core input and tendril-like structures The structural complexity indicators included a power-law fitting model and its scale parameter Conclusions The core network could be extracted based on the subgroup analysis of the overall network of the HIF-1 signaling pathway The critical elements of the network could be identified in the centrality analysis The results of the study show the feasibility and effectiveness of the network analytical method used to explore the network properties of the HIF-1 signaling pathway and provide support for further research

Publication search with Hypoxia response network as keyword

A structural analysis of the hypoxia response network

Publication search
with Hypoxia response network as keyword