Takao, Ken Tani, Ayaka Suwa, Tetsuya Kuwabara-Ohmura, Yayoi Nonomura, Kenta Liu, Yanyan Kato, Takehiro Mizuno, Masami Hirota, Takuo Enya, Mayumi
...
Published in
BMC Endocrine Disorders
BackgroundPrimary central nervous system lymphoma is a rare extra-nodal lymphoma of the central nervous system. Primary central nervous system lymphoma lesions usually appear in the vicinity of the ventricle, and there are few reports of primary central nervous system lymphoma with hypothalamic-pituitary lesions.Case presentationWe treated a 56-yea...
Dutra, Sabrina G.V. Paterson, Alex Monteiro, Livia R.N. Greenwood, Michael P. Greenwood, Mingkwan P. Amaral, Ludimila S. Melo, Mariana R. Colombari, Débora S.A. Colombari, Eduardo Reis, Luís C.
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Published in
Neuroendocrinology
Background/Aims: Furosemide is a loop diuretic widely used in clinical practice for the treatment of oedema and hypertension. The aim of this study was to determine physiological and molecular changes in the hypothalamic-neurohypophysial system as a consequence of furosemide-induced sodium depletion. Methods: Male rats were sodium depleted by acute...
Lord, Magen N Subramanian, Keshav Kanoski, Scott E Noble, Emily E
Published in
Peptides
Given the increased prevalence of obesity and its associated comorbidities, understanding the mechanisms through which the brain regulates energy balance is of critical importance. The neuropeptide melanin-concentrating hormone (MCH) is produced in the lateral hypothalamic area and the adjacent incerto-hypothalamic area and promotes both food intak...
Si, Yanpo Wang, Lili Lan, Jinxu Li, Hanwei Guo, Tao Chen, Xiaohui Dong, Chunhong Ouyang, Zhen Chen, Sui-Qing
Published in
Pharmaceutical biology
Lilium davidii var. unicolour Cotton (Lilium genus, Liliaceae) is an edible plant and a herb used in China to alleviate insomnia. To investigate the alleviating insomnia mechanism of L. davidii (LD). Wistar rats were intraperitoneally injected with p-chlorophenylalanine (PCPA) to establish an insomnia model. Rats were divided into six groups (n = 8...
Winters, Stephen J Moore, Joseph P Jr
Published in
Molecular and cellular endocrinology
Pituitary adenylate cyclase-activating polypeptide (PACAP) is an ancestral molecule that was isolated from sheep hypothalamic extracts based on its action to stimulate cAMP production by pituitary cell cultures. PACAP is one of a number of ligands that coordinate with GnRH to control reproduction. While initially viewed as a hypothalamic releasing ...
Shalev, Dor Melamed, Philippa
Published in
Molecular and cellular endocrinology
Puberty is programmed through a multifactorial gene network which works to activate the pulsatile secretion of the gonadotropin releasing hormone (GnRH), and subsequently elevate circulating levels of the pituitary gonadotropins that stimulate gonadal activity. Although this developmental transition normally occurs at a limited age-range in individ...
Yu, Kaifan He, Yanlin Hyseni, Ilirjana Pei, Zhou Yang, Yongjie Xu, Pingwen Cai, Xing Liu, Hesong Qu, Na Liu, Hailan
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Published in
Molecular metabolism
Estrogen protects animals from obesity through estrogen receptor α (ERα), partially by inhibiting overeating in animals fed ad libitum. However, the effects of estrogen on feeding behavior in hungry animals remain unclear. In this study, we examined the roles of 17β-estradiol (E2) and ERα in the regulation of feeding in hungry female animals and ex...
Lee, Sung Jun Jang, Sung Ho
Published in
Clinical autonomic research : official journal of the Clinical Autonomic Research Society
Franco-Pérez, Javier Montes, Sergio Sánchez-Hernández, Josué Ballesteros-Zebadúa, Paola
Published in
Radiation Oncology
BackgroundWhole-brain radiotherapy is a primary treatment for brain tumors and brain metastasis, but it also induces long-term undesired effects. Since cognitive impairment can occur, research on the etiology of secondary effects has focused on the hippocampus. Often overlooked, the hypothalamus controls critical homeostatic functions, some of whic...
Barretto-de-Souza, Lucas Benini, Ricardo Reis-Silva, Lilian L Crestani, Carlos C
Published in
Brain research bulletin
The lateral hypothalamus (LH) is implicated in the physiological and behavioral responses during stressful events. However, the local neurochemical mechanisms related to control of stress responses by this hypothalamic area are not completely understood. Therefore, in this study we evaluated the involvement of CRFergic neurotransmission acting thro...
