Yang, Neil Victor Pannia, Emanuela Chatterjee, Diptendu Kubant, Ruslan Ho, Mandy Hammoud, Rola Pausova, Zdenka Anderson, G Harvey
Published in
Nutritional neuroscience
Background: Folic acid plays an important role in early brain development of offspring, including proliferation and differentiation of neural stem cells known to impact the function of food intake regulatory pathways. Excess (10-fold) intakes of folic acid in the gestational diet have been linked to increased food intake and obesity in male rat off...
Jehl, F. Désert, C. Klopp, C. Brenet, M. Rau, A. Leroux, S. Boutin, M. Lagoutte, L. Muret, K. Blum, Y.
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Published in
BMC Genomics
BackgroundProduction conditions of layer chicken can vary in terms of temperature or diet energy content compared to the controlled environment where pure-bred selection is undertaken. The aim of this study was to better understand the long-term effects of a 15%-energy depleted diet on egg-production, energy homeostasis and metabolism via a multi-t...
Mehta, P. Fahlbusch, F. B. Rades, D. Schmid, S. M. Gebauer, J. Janssen, S.
Published in
BMC Cancer
BackgroundCranial radiotherapy (cRT) can induce hormonal deficiencies as a consequence of significant doses to the hypothalamic-pituitary (HP) axis. In contrast to profound endocrinological follow-up data from survivors of childhood cancer treated with cRT, little knowledge exists for adult cancer patients.MethodsA systematic search of the literatu...
Kanno, Naoko Fujiwara, Ken Yoshida, Saishu Kato, Takako Kato, Yukio
Published in
Cells Tissues Organs
Neuronatin (NNAT) was first identified as a gene selectively and abundantly expressed in the cytoplasm of the newborn mouse brain, and involved in neonatal neurogenesis. However, the particular roles of NNAT in the developing prenatal brain have not been identified, especially in mid to late stages. In this study, we performed immunohistochemical a...
Pedroso, Amanda P Dornellas, Ana P S de Souza, Adriana P Pagotto, Josias F Oyama, Lila M Nascimento, Cláudia M O Klawitter, Jelena Christians, Uwe Tashima, Alexandre K Ribeiro, Eliane Beraldi
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Published in
European journal of nutrition
Intrauterine growth restriction (IUGR) has been shown to induce the programming of metabolic disturbances and obesity, associated with hypothalamic derangements. The present study aimed at investigating the effects of IUGR on the protein and metabolite profiles of the hypothalamus of adult female rats. Wistar rats were mated and either had ad libit...
de-Lima-Júnior, José C Rodovalho, Sylka Van de Sande-Lee, Simone Monfort-Pires, Milena Rachid, Briana Cintra, Riobaldo M Ramos, Celso D Cendes, Fernando Folli, Franco Velloso, Lício A
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Published in
Acta diabetologica
This study aimed to evaluate the effect of pioglitazone on brown adipose tissue function and hypothalamic gliosis in humans. Brown adipose tissue and the hypothalamus are regarded as important potential pharmacological targets to metabolic diseases, and defining the impact of current therapies on their structure and/or function could provide therap...
Lee, Chan Hee Shin, Sung Hoon Kang, Gil Myoung Kim, Seongjun Kim, Jiye Yu, Rina Kim, Min-Seon
Published in
Journal of Neuroinflammation
BackgroundObese mice on a high-fat diet (HFD) display signs of inflammation in the hypothalamic arcuate nucleus (ARC), a critical area for controlling systemic energy metabolism. This has been suggested as a key mechanism of obesity-associated hypothalamic dysfunction. We reported earlier that bone marrow-derived macrophages accumulate in the ARC t...
Yonemochi, Naomi Ardianto, Chrismawan Yang, Lizhe Yamamoto, Shogo Ueda, Daiki Kamei, Junzo Waddington, John L Ikeda, Hiroko
Published in
Biochemical and biophysical research communications
This study investigated dopaminergic function in the lateral hypothalamus (LH) in the regulation of feeding behavior. Refeeding increased dopamine levels in the LH. Glucose injection also increased dopamine levels in the LH. When the retrograde tracer Fluoro-Gold (FG) was injected into the LH, FG-positive cells were found in the ventral tegmental a...
Wang, Di Xu, Bin Wang, Jianfa Wang, Hai Guo, Jingru Ji, Hong Li, Shize Wu, Rui Yang, Huanmin Lian, Shuai
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Published in
Brain research
Maternal stress is a key risk factor in the development of offspring. We previously identified prenatal cold stress-induced anxiety-like behavior reduced in the offspring of rats along with negative feedback regulation from the maternal hippocampus on the hypothalamic-pituitary-adrenal (HPA) axis during prenatal cold stress. However, the precise fu...
Lainez, Nancy M Coss, Djurdjica
The increasing occurrence of obesity has become a significant public health concern. Individuals with obesity have higher prevalence of heart disease, stroke, osteoarthritis, diabetes, and reproductive disorders. Reproductive problems include menstrual irregularities, pregnancy complications, and infertility due to anovulation, in women, and lower ...
