Messe, R Guillien, A Claudé, F Laurent, L Degano, B
Published in
Revue des maladies respiratoires
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality, especially in cases of chronic hypercapnic respiratory failure. Following a prolonged debate, the indication and benefits of noninvasive ventilation (NIV) have been recently established. Although improved ventilation and reduction in hyperinflation appear to u...
Eynan, Mirit
Published in
Diving and hyperbaric medicine
Atangana, Ernestine Atangana, Abdon
Published in
Results in Physics
In the last few months, the spread of COVID-19 among humans has caused serious damages around the globe letting many countries economically unstable. Results obtained from conducted research by epidemiologists and virologists showed that, COVID-19 is mainly spread from symptomatic individuals to others who are in close contact via respiratory dropl...
Moon, Richard E
Published in
Diving and hyperbaric medicine
Zhou, Dawei Li, Zhimin Zhang, Shaolan Wu, Lei Li, Yiyuan Shi, Guangzhi Zhou, Jianxin
Published in
BMC Anesthesiology
BackgroundWe sought to evaluate the effect of mild hypercapnia on brain tissue oxygen tension (Pbto2) and diffusion limitation (impaired ability of oxygen extraction) in a porcine post asphyxial cardiac arrest model.MethodsIn 16 Bama pigs, asphyxial cardiac arrest was induced by endotracheal tube clamping and remained untreated for another 4 min. A...
Webster, Lynn R. Hansen, Erik Cater, Jacqueline Smith, Thomas
Published in
Advances in Therapy
Introduction Buprenorphine is a partial μ-opioid receptor agonist that, unlike full μ-opioid receptor agonists, has been shown to have a ceiling effect on respiratory depression. Buprenorphine buccal film (BBF) is approved by the US Food and Drug Administration for use in patients with chronic pain severe enough to require daily, around-the-clock, ...
Vermeulen, Tyler D Benbaruj, Jenna Brown, Courtney V Shafer, Brooke M Floras, John S Foster, Glen E
Published in
Experimental neurology
The decline in cognition observed in obstructive sleep apnea is linked to intermittent hypercapnic hypoxia (IHH), which is known to impair cerebrovascular reactivity. Whether acute IHH impairs the matching of cerebral blood flow to metabolism (i.e., neurovascular coupling, NVC) is unknown. We hypothesized that acute IHH would reduce cerebral NVC. H...
Li, Na Liu, Yumei Zhao, Ying Wu, Xiaoguang Tong, Junyao Hua, Yang
Published in
Sleep medicine
Impaired cerebrovascular reactivity (CVR) in patients with obstructive sleep apnea syndrome (OSAS) increases the risk of ischemic stroke. CVR also decreases with age in normal individuals. However, it is unclear whether OSAS affects CVR differently in young and old patients. The aim of this study was to compare CVR in old and young patients with OS...
Yamashita, Tomonori Uchiyama, Akinori Koyama, Yukiko Yoshida, Takeshi Tanaka, Aiko Fujino, Yuji
Published in
Respiratory physiology & neurobiology
This study aimed to investigate the effects of alkaline agents on reducing strong inspiratory effort. Rabbits with hypercapnia or lung injury, induced via repeated lung lavage following injurious ventilation, were treated with Saline, NaHCO3, or Trometamol. In the hypercapnia, minute ventilation and tidal volume were unchanged during NaHCO3 adminis...
May, Alexandra G. Orizondo, Ryan A. Frankowski, Brian J. Ye, Sang-Ho Kocyildirim, Ergin Wagner, William R. D’Cunha, Jonathan Federspiel, William J.
Published in
Intensive Care Medicine Experimental
BackgroundNon-invasive and lung-protective ventilation techniques may improve outcomes for patients with an acute exacerbation of chronic obstructive pulmonary disease or moderate acute respiratory distress syndrome by reducing airway pressures. These less invasive techniques can fail due to hypercapnia and require transitioning patients to invasiv...
