Nonhepatic Hyperammonemic Encephalopathy (NHE) after bariatric and metabolic surgery: A clinically challenging diagnosis...
Published in Asian journal of surgery
Nonhepatic Hyperammonemic Encephalopathy (NHE) after bariatric and metabolic surgery: A clinically challenging diagnosis...
The effects of Ibuprofen and 1, 8- cineol on anxiety and spatial memory in hyperammonemic rats.
Published in Metabolic brain disease
In hepatic encephalopathy, hyperammonemia (HA) causes cognitive impairment and anxiety by causing neuroinflammation. Ibuprofen and 1,8- cineol have anti-inflammatory and antioxidant properties, respectively. The aim of this study was to evaluate the effects of ibuprofen alone and in combination with 1,8- cineol on anxiety and oxidative stress in a ...
Hyperammonemia in Inherited Metabolic Diseases.
Published in Cellular and molecular neurobiology
Ammonia is a neurotoxic compound which is detoxified through liver enzymes from urea cycle. Several inherited or acquired conditions can elevate ammonia concentrations in blood, causing severe damage to the central nervous system due to the toxic effects exerted by ammonia on the astrocytes. Therefore, hyperammonemic patients present potentially li...
Acute hemodialysis therapy in neonates with inborn errors of metabolism.
...Published in Pediatric nephrology (Berlin, Germany)
Inborn errors of metabolism (IEM), including organic acidemias and urea cycle defects, are characterized by systemic accumulation of toxic metabolites with deleterious effect on the developing brain. While hemodialysis (HD) is most efficient in clearing IEM-induced metabolic toxins, data regarding its use during the neonatal period is scarce. We re...
A review of basic to clinical studies of the association between hyperammonemia, methamphetamine.
Published in Naunyn-Schmiedeberg's archives of pharmacology
Methamphetamine (METH), an addictive psychostimulant drug, is the second most widely used type of drug all around the world. METH abusers are more likely to develop a psycho-neurological complication. Hyperammonemia (HAM) causes neuropsychiatric illnesses such as mental state changes and episodes of acute encephalopathy. Recently, there are some sh...
Hyperammonemia Enhances GABAergic Neurotransmission in Hippocampus: Underlying Mechanisms and Modulation by Extracellula...
Published in Molecular neurobiology
Rats with chronic hyperammonemia reproduce the cognitive and motor impairment present in patients with hepatic encephalopathy. It has been proposed that enhanced GABAergic neurotransmission in hippocampus may contribute to impaired learning and memory in hyperammonemic rats. However, there are no direct evidences of the effects of hyperammonemia on...
Interorgan amino acid interchange in propionic acidemia: the missing key to understanding its physiopathology.
Published in Amino acids
Propionic acidemia is an inborn error of metabolism caused by a deficiency in the mitochondrial enzyme propionyl-CoA carboxylase that converts the propionyl CoA to methyl malonyl CoA. This leads to profound changes in distinct metabolic pathways, including the urea cycle, with consequences in ammonia detoxification. The implication of the tricarbox...
Emergency management of critically ill adult patients with inherited metabolic disorders.
Published in The American journal of emergency medicine
An increasing number of pediatric patients with inherited metabolic disorders are reaching adulthood. In addition, many patients are diagnosed for the first time in adult life due to improved awareness of these disorders and the availability of advanced diagnostic technology. Knowledge of these inherited metabolic disorders in adults is crucial for...
Corticosteroid suppresses urea-cycle-related gene expressions in ornithine transcarbamylase deficiency
...
Published in BMC Gastroenterology
Background Ornithine transcarbamylase deficiency (OTCD) is most common among urea cycle disorders (UCDs), defined by defects in enzymes associated with ureagenesis. Corticosteroid administration to UCD patients, including OTCD patients, is suggested to be avoided, as it may induce life-threatening hyperammonemia. The mechanism has been considered n...
Hyperammonemia of unknown cause in a young postpartum woman: a case report.
Published in Journal of medical case reports
Hyperammonemia is a medical condition described as increased or elevated serum ammonia levels. High serum levels of ammonia can cause neurotoxicity. Sudden onset severe hyperammonemia may cause severe encephalopathy with brain damage. It can result in cerebral edema, emesis, seizures, hypotonia, and death. We report a young postpartum woman who had...
