Dzuman, Zbynek Jonatova, Petra Stranska-Zachariasova, Milena Prusova, Nela Brabenec, Ondrej Novakova, Alena Fenclova, Marie Hajslova, Jana
Published in
Analytical and bioanalytical chemistry
Setting of maximum limits for a number of plant alkaloids is under discussion in the EU. The novel method developed and optimized in this study enables simultaneous determination of 21 tropane alkaloids (TAs) and 33 pyrrolizidine (PAs) together with their N-oxides (PANOs). For analysis of aqueous-methanolic extract, reversed phase ultra-high-perfor...
Ganewatta, Nisansala El Rassi, Ziad
Published in
Journal of Analytical Science and Technology
This research article presents the preparation and characterization of monolithic columns with incorporated bare fumed silica nanoparticles (FSNPs) and cyano-modified FNSPs (CN-FSNPs) and their subsequent use in hydrophilic interaction liquid chromatography (HILIC) of neutral, polar, and low molecular weight solutes. The monolithic support was base...
Yeung, Darien Klaassen, Nicole Mizero, Benilde Spicer, Victor Krokhin, Oleg V
Published in
Journal of chromatography. A
Peptide retention time prediction models have been developed for zwitter-ionic ZIC-HILIC and ZIC-cHILIC stationary phases (pH 4.5 eluents) using proteomics-derived retention datasets of ~30 thousand tryptic peptides each. Overall, hydrophilicity of these stationary phases was found to be similar to the previously studied Amide HILIC phase, but lowe...
Li, Kun Zhao, Bao Yu, Qingcai Xu, Juan Li, Xuewei Wei, Diandian Qian, Lisheng Liu, Guodong Wang, Wenrui
Published in
Microchimica Acta
A porous hydrophilic affinity bead consisting of graphene oxide and chitosan (pGC) with the honeycomb-biomimetic microchannels has been synthesized and applied as hydrophilic adsorbent for selective capture of glycopeptides. The pGC beads have open-porous structure, honeycomb-like microchannels, large interior voids, and hydrophilic property. Based...
Sun, Nianrong Wu, Hao Shen, Xizhong
Published in
Microchimica Acta
A dual functionalized magnetic nanomaterial was fabricated by combining the magnetic core, titania shell, and hydrophilic molecules (denoted as [email protected]). Based on the mechanism of metal oxide affinity chromatography and hydrophilic interaction liquid chromatography, the sorbent shows excellent one-step separation capacity for both glycopepti...
Kozlik, Petr Hasikova, Lenka Stiburkova, Blanka Zavada, Jakub Kalikova, Kveta
Published in
Analytical biochemistry
Allantoin is an excellent biomarker of oxidative stress in humans as the main product of uric acid oxidation by reactive oxygen species. Yet, allantoin determination is still not routinely performed in clinical laboratories. Therefore, we developed a fast, simple, selective, and sensitive UHPLC-MS/MS method for allantoin determination in human seru...
Herrera López, Sonia Dias, Jonatan
In this work, a method for the analysis of 14 highly polar pesticides in animal origin matrices by hydrophilic interaction liquid chromatography and mass spectrometry has been described. Three methanol-based extraction procedures with slight modifications, depending on the matrix, have been used. The method has been validated according to the perfo...
Li, Amy Hines, Kelly M Xu, Libin
Published in
Methods in molecular biology (Clifton, N.J.)
Lipidomics is a rapidly growing field that enables the characterization of the entire lipidome in cells, tissues, or an organism. Changes in lipid metabolism and homeostasis caused by different disease states or drug treatments can be probed by lipidomics experiments, which can aid our understanding of normal physiology and disease pathology at the...
Henschel, Jonas Wiemers-Meyer, Simon Diehl, Marcel Lürenbaum, Constantin Jiang, Wen Winter, Martin Nowak, Sascha
Published in
Journal of chromatography. A
The expansion of lithium ion battery (LIB) application is accompanied by the growth of battery pack sizes. This progression emphasizes the consideration of electrolyte safety as well as environmental aspects in case of abuse, accident, or recycling. Hexafluorophosphate is one of the most commonly used conducting salt anions in electrolytes. It has ...
Fall, Fanta Lenuzza, Natacha Lamy, Elodie Brollo, Marion Naline, Emmanuel Devillier, Philippe Thévenot, Etienne Grassin-Delyle, Stanislas
Published in
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
Untargeted metabolomics of human plasma with mass spectrometry is of particular interest in medical research to explore pathophysiology, find disease biomarkers or for the understanding of the response to pharmacotherapy. Since analytical performances may be impacted by the laboratory environment and the acquisition method settings, the objectives ...
