Kotik, Michael Kulik, Natalia Valentová, Kateřina
Published in
Journal of agricultural and food chemistry
Flavonoids and their glycosides are abundant in many plant-based foods. The (de)glycosylation of flavonoids by retaining glycoside hydrolases has recently attracted much interest in basic and applied research, including the possibility of altering the glycosylation pattern of flavonoids. Research in this area is driven by significant differences in...
Tétreault, J. Vedoy, D. Bégin, P. Paris Lacombe, S. Dupont, Anne-Laurence
There has always been an interest in the professional communities of libraries, archives and conservation science to find ways of estimating the rate of degradation of paper under archival conservation conditions. Previously we reported a number of considerations for developing a kinetic degradation model based on Whatman no.1 paper. In the present...
Ohura, Kayoko Nakada, Yuichiro Imai, Teruko
Published in
Journal of pharmaceutical sciences
Fluphenazine (FPZ) decanoate, an ester-type prodrug formulated as a long-acting injection (LAI), is used in the treatment of schizophrenia. FPZ enanthate was also developed as an LAI formulation, but is no longer in use clinically because of the short elimination half-life of FPZ, the parent drug, after intramuscular injection. In the present study...
Jakaria, Sardar M Budil, David E Murtagh, James
Published in
Journal of pharmaceutical sciences
The degradation kinetics of the glycopeptide antibiotic dalbavancin in solution are systematically evaluated over the pH range 1-12 at 70°C. The decomposition rate of dalbavancin was measured as a function of pH, buffer composition, temperature, ionic strength, and drug concentration. A pH-rate profile was constructed using pseudo first-order kinet...
Azhari, Zein Smith, Patricia McMahon, Sean Wang, Wenxin Cameron, Ruth E
Published in
Pharmaceutical research
This paper investigates drug release from a novel series of mPEG-functionalised PLLA polymers whose individual components (PEG and PLLA) have regulatory FDA approval. Two processing methods were explored to understand their effect on the morphology and drug release profiles of the polymers, with and without mPEG functionalisation. In the first meth...
Gaudin, Etienne Al Asmar, Eliane Bobet, Jean-Louis
Composites materials Mg-NdNiMg15 can be easily obtained by directly melting pure elements. Young modulus and hardness can be varied from 43.5 to 48.8 GPa and 45–225 HV respectively. Nevertheless, the corrosion resistance of these composites is really poor, preventing a potential structural application. The use of composites Mg-NdNiMg15 for the prod...
Shimizu, Mai Fukami, Tatsuki Okura, Keisho Taniguchi, Toshio Nomura, Yukihiro Nakajima, Miki
Published in
Journal of pharmaceutical sciences
Development of prodrugs is a useful strategy to overcome some disadvantages of candidate drugs. Recently, we established a systematic approach to selecting appropriate prodrugs, and validated the utility of this approach using oseltamivir analogues. In this study, the utility of the approach was further examined using candesartan cilexetil and 20 k...
Shalaev, Evgenyi Ohtake, Satoshi Moussa, Ehab M Searles, Jim Nail, Steven Roberts, Christopher J
Published in
Journal of pharmaceutical sciences
Prediction of lyophilized product shelf-life using accelerated stability data requires understanding the temperature dependence of the degradation rate. Despite the abundance of published studies on stability of freeze-dried formulations and other amorphous materials, there are no definitive conclusions on the type of pattern one can expect for the...
Alegre Calvo, Esther
[ES] Los mataderos e industrias cárnicas generan una gran cantidad de subproductos que se destinan a usos de bajo valor económico como son la producción de fertilizantes, biodiesel o biogas, entre otras aplicaciones. Sin embargo, existe un gran interés por revalorizar dichos residuos y obtener productos de valor añadido que puedan ser utilizados ta...
Acin‐Perez, Rebeca Benincá, Cristiane del Rio, Lucia Fernandez Shu, Cynthia Baghdasarian, Siyouneh Zanette, Vanessa Gerle, Christoph Jiko, Chimari Khairallah, Ramzi Khan, Shaharyar
...
The maintenance of cellular function relies on the close regulation of adenosine triphosphate (ATP) synthesis and hydrolysis. ATP hydrolysis by mitochondrial ATP Synthase (CV) is induced by loss of proton motive force and inhibited by the mitochondrial protein ATPase inhibitor (ATPIF1). The extent of CV hydrolytic activity and its impact on cellula...
