Liu, Aiping Long, Yin Li, Jun Gu, Long Karim, Aos Wang, Xudong Gibson, Angela L. F.
Published in
Journal of Nanobiotechnology
Background Electrostimulation (ES) therapy for wound healing is limited in clinical use due to barriers such as cumbersome equipment and intermittent delivery of therapy. Methods We adapted a human skin xenograft model that can be used to directly examine the nanogenerator-driven ES (NG-ES) effects on human skin in vivo—an essential translational s...
Ederer, Ines Ana Reutzsch, Franziska Leandra Schäfer, Ruth Christine Wahler, Theodora Daigeler, Adrien Rieger, Ulrich Michael Rothenberger, Jens
Published in
The Journal of surgical research
The safe execution of local flaps tends to be challenging for surgical residents. Thus, the purpose of the study was to evaluate a training model of local flaps based on fresh human skin excised from body contouring procedures. A questionnaire and surgical skills evaluation-analyzing the theoretical and procedural knowledge about local flaps-were h...
Hirose, Ryohei Bandou, Risa Ikegaya, Hiroshi Watanabe, Naoto Yoshida, Takuma Daidoji, Tomo Naito, Yuji Itoh, Yoshito Nakaya, Takaaki
Published in
Clinical Microbiology and Infection
Objectives Disinfection effectiveness against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on human skin remains unclear because of the hazards of viral exposure. An evaluation model, which has been previously generated using human skin obtained from forensic autopsy samples, accurately mimics in vivo skin conditions for evaluating ...
Letsiou, Sophia
Published in
Biogerontology
Skin is a rather complex, yet useful organ of our body. Besides, skin aging is a complicated process that gains a growing interest as mediates many molecular processes in our body. Thus, an efficient skin model is important to understand skin aging function as well as to develop an effective innovative product for skin aging treatment. In this mini...
Steinritz, Dirk Lüling, Robin Siegert, Markus Herbert, Julia Mückter, Harald Taeger, Christian D. Gudermann, Thomas Dietrich, Alexander Thiermann, Horst John, Harald
...
Published in
Archives of Toxicology
Sulfur mustard (SM) is a chemical warfare agent which use is banned under international law and that has been used recently in Northern Iraq and Syria by the so-called Islamic State. SM induces the alkylation of endogenous proteins like albumin and hemoglobin thus forming covalent adducts that are targeted by bioanalytical methods for the verificat...
Sachs, David Wahlsten, Adam Kozerke, Sebastian Restivo, Gaetana Mazza, Edoardo
Published in
Biomechanics and Modeling in Mechanobiology
The present study investigates the layer-specific mechanical behavior of human skin. Motivated by skin’s histology, a biphasic model is proposed which differentiates between epidermis, papillary and reticular dermis, and hypodermis. Inverse analysis of ex vivo tensile and in vivo suction experiments yields mechanical parameters for each layer and p...
Chato-Astrain, Jesús Chato-Astrain, Isabel Sánchez-Porras, David García-García, Óscar-Darío Bermejo-Casares, Fabiola Vairo, Claudia Villar-Vidal, María Gainza, Garazi Villullas, Silvia Oruezabal, Roke-Iñaki
...
Published in
Journal of Nanobiotechnology
BackgroundTreatment of patients affected by severe burns is challenging, especially due to the high risk of Pseudomonas infection. In the present work, we have generated a novel model of bioartificial human dermis substitute by tissue engineering to treat infected wounds using fibrin-agarose biomaterials functionalized with nanostructured lipid car...
Vijayan, Suvarna Mini Göen, Thomas Dennerlein, Kathrin Horch, R E Ludolph, I Drexler, Hans Kilo, Sonja
Published in
Toxicology in vitro : an international journal published in association with BIBRA
The fluoride ions of the industrially largely irreplaceable, locally corrosive hydrofluoric acid (HF) can scavenge cations in biological tissues, which explains their high toxic potential, and also leads to local acidification through proton release. The influence of three complexing agents, calcium (Ca2+) gluconate (as 2.5% Ca2+gel and individuall...
Hama, Tetsuya Kouchi, Akira Watanabe, Naoki Shioya, Nobutaka Shimoaka, Takafumi Hasegawa, Takeshi
Published in
Biophysical chemistry
An in vivo analysis of stearyl alcohol and stearic acid films on the skin surface using polarized infrared-external reflection spectroscopy revealed that whether the sample molecules adopt an energetically stable conformation and orientation strongly depends on the molecular functionalities and sample preparation conditions. For stearic acid, even ...
Raude, Emma
Les modèles organotypiques tels que les explants de peau humaine sont les modèles les plus complexes et parmi les plus représentatifs de la peau in vivo existants à ce jour pour tester l’efficacité ou l’innocuité de molécules d’intérêts thérapeutiques au stade des études pré-cliniques. Cependant, l’absence de circulation sanguine et lymphatique dan...
