Liu, Xueping Nudel, Ron Thompson, Wesley K Appadurai, Vivek Schork, Andrew J Buil, Alfonso Rasmussen, Simon Allesøe, Rosa L Werge, Thomas Mors, Ole
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Published in
Brain, behavior, and immunity
Previous studies have indicated the bidirectionality between autoimmune and mental disorders. However, genetic studies underpinning the co-occurrence of the two disorders have been lacking. In this study, we examined the potential genetic contribution to the association between autoimmune and mental disorders and investigated the genetic basis of o...
Zheng, Yuanyuan Ma, Cui Liu, Xiaowei Wu, Shaowen Zhang, Weiyuan Zhao, Shenglong
Published in
BMC Pregnancy and Childbirth
BackgroundPreeclampsia is an idiopathic disease during pregnancy. This study explores the correlation between HLA-A polymorphism and the onset of preeclampsia.MethodsThe Illumina HiSeq2500 sequencing platform was used to genotyping HLA-A allele in venous blood DNA of 50 preeclampsia pregnant women and 48 normal pregnant women and umbilical cord blo...
Kachuri, Linda Francis, Stephen S Morrison, Maike L Wendt, George A Bossé, Yohan Cavazos, Taylor B Rashkin, Sara R Ziv, Elad Witte, John S
BACKGROUND:Humans and viruses have co-evolved for millennia resulting in a complex host genetic architecture. Understanding the genetic mechanisms of immune response to viral infection provides insight into disease etiology and therapeutic opportunities. METHODS:We conducted a comprehensive study including genome-wide and transcriptome-wide associa...
Mahmood, Malik Siddique Bin-T-Abid, Duaa Irshad, Saba Batool, Hina
Published in
International Journal of Peptide Research and Therapeutics
Tuberculosis (TB), a chronic disease caused by Mycobacterium tuberculosis (Mtb) , is a global health issue across the world. Pakistan ranks fifth among the countries, which are facing, a significantly great number of mortalities and morbidities due to TB. Unfortunately, all previously reported treatments are not successful for the eradication of T...
Zhao, Ting Li, Hong-Jian Wang, Ting-Ting Bahatibieke, Maerjiang Jia, Li Wang, Feng Liu, Wen-Li Ji, Yong Sun, Li Sun, Yan
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Published in
Epilepsy research
To determine genetic associations between antiseizure medications (ASMs)-induced maculopapular eruption (MPE) and human leukocyte antigen (HLA) variants in Xinjiang, China. A total of 409 patients were enrolled in this study, including 36 subjects with ASMs-induced MPE (case group) and 373 ASMs-tolerant patients (control group). We detected the who...
Korsgaard, Trine Joshi, Shivani Andersen, Rene F Moeller, Kristina Seeman, Tomás Podracká, Ludmila Eiberg, Hans Rittig, Søren
Published in
European journal of pediatrics
Steroid-sensitive nephrotic syndrome (SSNS) is the most common form of nephrotic syndrome in childhood. Cases with the familial occurrence of SSNS suggest that genetics may play a role in the disease. Human leucocyte antigen (HLA) alleles have been associated with SSNS. We present genetic findings in nine families (44 participants), each with at le...
Saribas, Suat Demiryas, Suleyman Yilmaz, Erkan Uysal, Omer Kepil, Nuray Demirci, Mehmet Caliskan, Reyhan Dinc, Harika Oyku Akkus, Seher Gareayaghi, Nesrin
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Published in
World Journal of Gastroenterology
BACKGROUND Polymorphisms of human leukocyte antigen (HLA) genes are suggested to increase the risk of gastric cancer (GC). AIM To investigate the HLA allele frequencies of patients with GC relative to a control group in terms of CagA+ multiple (≥ 2) EPIYA-C repeats. METHODS The patient group comprised 94 patients [44 GC and 50 duodenal ulcer (DU) p...
Ochoa, Eliana E. Huda, Ruksana Scheibel, Steven F. Nichols, Joan E. Mock, David J. El-Daher, Nayef Domurat, Frank M. Roberts, Norbert J. Jr
Published in
Virology Journal
BackgroundHeterozygosity at HLA class I loci is generally considered beneficial for host defense. We report here an element of HLA class I homozygosity that may or may not help preserve its existence in populations but which could indicate a new avenue for antiviral research.MethodsLymphocytes from serologically HLA-homozygous or -heterozygous dono...
Kwon, Daekee Ahn, Hee-Jin Han, Mi-Jung Ji, Minjun Ahn, Jongchan Seo, Kwang-Won Kang, Kyung-Sun
Published in
Stem cell reviews and reports
Mesenchymal stem cells (MSC) are an important type of cell that are highly recognized for their safety and efficacy as a cell therapy agent. In order to obtain MSC, primary tissues (adipose tissue, bone marrow, and umbilical cord blood) must be used; however, these tissues, especially umbilical cord blood, are difficult to obtain due to various rea...
Zhang, Quan Fan, Xing Tian, Meng Han, Hongling
Published in
BMC Nephrology
BackgroundVogt-Koyanagi-Harada syndrome is a rare disease characterized by skin and eyelash bleaching, chronic granulomatous iridocyclitis and exudative retinal detachment, and aseptic meningitis and encephalopathy. IgA nephropathy complicated by Vogt-Koyanagi-Harada syndrome is very rare, even though they might have similar pathogeneses. Ocular le...
