Unite to predict
Published in eLife
Integrating the analysis of molecular data from different sources may improve our understanding of the effects of biological aging.
Circulating cell-free nucleosomes as biomarker for kidney transplant rejection: a pilot study.
Published in Clinical epigenetics
There is an unmet need for noninvasive markers specific for kidney transplant rejection. Such a marker may eventually overcome the need for a transplant biopsy. In this pilot study, the potential of circulating cell-free nucleosomes (CCFN) to serve as a biomarker for kidney transplant rejection was evaluated. Forty de novo kidney transplant recipie...
Epigenetic Regulation of Gut Microbial Dysbiosis
Published in Indian Journal of Microbiology
Microbiota inside the gut plays a vital role in maintaining human health. Microbial dysbiosis is associated with various complications leading to a range of diseases. Epigenetic changes enforced by various environmental and lifestyle factors lead to heritable modifications. These epigenetic modifications include DNA methylation, histone modificatio...
A novel recessive mutation affecting DNAJB6a causes myofibrillar myopathy
...Published in Acta Neuropathologica Communications
Mutations in the DNAJB6 gene have been identified as rare causes of myofibrillar myopathies. However, the underlying pathophysiologica mechanisms remain elusive. DNAJB6 has two known isoforms, including the nuclear isoform DNAJB6a and the cytoplasmic isoform DNAJB6b, which was thought to be the pathogenic isoform. Here, we report a novel recessive ...
Interstitial Cells of Cajal and Neural Structures in the Human Fetal Appendix
Published in Journal of Neurogastroenterology and Motility
Background/Aims The interstitial cells of Cajal (ICC) are located within and around the digestive tract’s muscle layers. They function as intestinal muscle pacemakers and aid in the modification of enteric neurotransmission. The appendix’s unique position requires an appropriate contraction pattern of its muscular wall to adequately evacuate its co...
Unique structural solution from a VH3-30 antibody targeting the hemagglutinin stem of influenza A viruses
...
Broadly neutralizing antibodies (bnAbs) targeting conserved influenza A virus (IAV) hemagglutinin (HA) epitopes can provide valuable information for accelerating universal vaccine designs. Here, we report structural details for heterosubtypic recognition of HA from circulating and emerging IAVs by the human antibody 3I14. Somatic hypermutations pla...
The influence of gingival phenotype on the morphology of the maxillary central papilla
Published in BMC Oral Health
BackgroundPreservation of the interdental papilla is an essential part of the functional and esthetic rehabilitation of dental treatment. It has been described that thicker gingival tissues are more resistant to recession. The main objective of this investigation was to analyze whether a thin gingival phenotype represents a potential risk indicator...
Survival of the glycosylated.
Published in eLife
Osteocalcin is a bone matrix protein that acts like a hormone when it reaches the blood, and has different effects in mice and humans. © 2021, Blair and Schlesinger.
Analysis of virulence genes and molecular typing of Listeria monocytogenes isolates from human, food, and livestock from...
Published in Tropical Animal Health and Production
The frequency of Listeria monocytogenes isolates collected from a total of 1150 samples including food (n = 300), livestock (n = 50), and human clinical (n = 800) was evaluated during 2008–2016. Antimicrobial resistance patterns, virulence factors, and molecular characteristics of these isolates were analyzed using disk diffusion method, sequencing...
β-carotene oxygenase 2 deficiency-triggered mitochondrial oxidative stress promotes low-grade inflammation and metabolic...
...Published in Free radical biology & medicine
Low-grade inflammation is a critical pathological factor contributing to the development of metabolic disorders. β-carotene oxygenase 2 (BCO2) was initially identified as an enzyme catalyzing carotenoids in the inner mitochondrial membrane. Mutations in BCO2 are associated with inflammation and metabolic disorders in humans, yet the underlying mech...
