Zhao, Yalei Zhang, Fen Zhang, Xiaoli Li, Zuhong Li, Qian Ni, Tianzhi Wang, Ruojing Liu, Liangru He, Yingli Zhao, Yingren
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Published in
Regenerative therapy
The liver has an excellent ability to regenerate, and disrupted liver regeneration after various injuries leads to an unfavorable prognosis for patients. In this study, we sought to identify novel therapeutic hallmarks that are associated with yes-associated protein 1 (YAP1)-mediated hepatocyte proliferation during the process of liver regeneration...
Li, Xuan Fan, Shicheng Cai, Chenghui Gao, Yue Wang, Xinhui Zhang, Yifei Liang, Hangfei Li, Huilin Yang, Jie Huang, Min
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Published in
Acta pharmaceutica Sinica. B
Liver is the central hub regulating energy metabolism during feeding-fasting transition. Evidence suggests that fasting and refeeding induce dynamic changes in liver size, but the underlying mechanisms remain unclear. Yes-associated protein (YAP) is a key regulator of organ size. This study aims to explore the role of YAP in fasting- and refeeding-...
Roubtsova, Anna Garçon, Damien Lacoste, Sandrine Chamberland, Ann Marcinkiewicz, Jadwiga Métivier, Raphaël Sotin, Thibaud Paquette, Martine Bernard, Sophie Cariou, Bertrand
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Published in
Biochimica et biophysica acta. Molecular and cell biology of lipids
PCSK9 promotes the lysosomal degradation of cell surface LDL receptor (LDLR). We analyzed how excess LDLR generated by PCSK9 deficiency is differently handled in male and female mice to possibly unveil the mechanism leading to the lower efficacy of PCSK9 mAb on LDL-cholesterol levels in women. Analysis of intact or ovariectomized PCSK9 knockout (KO...
Yang, Insook Son, Yeri Shin, Jae Hoon Kim, Il Yong Seong, Je Kyung
Published in
BMB reports
Ahnak, a large protein first identified as an inhibitor of TGF-β signaling in human neuroblastoma, was recently shown to promote TGF-β in some cancers. The TGF-β signaling pathway regulates cell growth, various biological functions, and cancer growth and metastasis. In this study, we used Ahnak knockout (KO) mice that underwent a 70% partial hepate...
Lei, Xiaohua Dai, Xiaoming Wang, Qian Long, Ruchang Xiang, Zhiqiang Li, Huajian Long, Zhangtao Zhang, Chao Zhu, Zhu
Published in
Biochemical and biophysical research communications
Characterized by compensatory hyperplasia dependent on hepatocyte proliferation, the liver will initiate regeneration after partial hepatectomy (PH) and acute or chronic injuries. A variety of genes and noncoding RNAs play pivotal roles in these cell proliferation and growth processes. However, it is still unclear how competition endogenous RNAs (c...
Martucci, Nicole Michalopoulos, George K Mars, Wendy M
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Gene expression
Integrin linked kinase (ILK) is a vital signaling protein ubiquitously expressed throughout the body. It binds to intracellular integrins to help promote signaling related to cell adhesion, apoptosis, proliferation, migration, and a plethora of other common cellular functions. In this review, ILKs role in the liver is detailed. Studies have shown I...
Shubham, Smriti Kumar, Dhananjay Rooge, Sheetalnath Maras, Jaswinder Sing Maheshwari, Deepanshu Nautiyal, Nidhi Kumari, Rekha Bhat, Adil Kumar, Guresh Rastogi, Archana
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Published in
Hepatology international
Acute hepatic insult triggers regeneration. If acute-on-chronic liver failure (ACLF) patients have a poorer regenerative response than acute liver failure (ALF) patients, and if so, the mechanisms underlying this, are not well understood. We investigated the status of hepatocyte proliferation, hepatic progenitor cell (HPC) mediated regeneration, no...
Wabitsch, Simon Benzing, Christian Krenzien, Felix Splith, Katrin Haber, Philipp Konstantin Arnold, Alexander Nösser, Maximilian Kamali, Can Hermann, Felix Günther, Christiane
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Published in
The Journal of surgical research
Mesenchymal stem cells (MSCs) have been suggested to augment liver regeneration after surgically and pharmacologically induced liver failure. To further investigate this we processed human bone marrow-derived MSC according to good manufacturing practice (GMP) and tested those cells for their modulatory capacities of metabolic alterations and liver ...
Agarwal, Nandini Popovic, Branimir Martucci, Nicole J Fraunhoffer, Nicolas A Soto-Gutierrez, Alejandro
Published in
Gene expression
Directed differentiation of hepatocytes from induced pluripotent stem cells (iPSCs) holds promise as source material for treating some liver disorders. The unlimited availability of perfectly differentiated iPSC-derived hepatocytes will dramatically facilitate cell therapies. While systems to manufacture large quantities of iPSC-derived cells have ...
Tsugawa, Yoji Hiramoto, Masaki Imai, Takeshi
Published in
Biochemical and biophysical research communications
Partial hepatectomy (PH) induces estradiol production, and then hepatocyte proliferation. Estradiol may play a role in triggering hepatocyte proliferation after PH. In this study, estradiol was injected to the Estrogen Receptor alpha (ERα) or ERβ KO mice. No increased hepatocyte proliferation was observed in ERα KO mice, indicates that ERα is invol...
