Chen, Shanshan Huang, Haijun Huang, Wei
Published in
BMC Gastroenterology
BackgroundAt present, most assessments of liver fibrosis staging mainly focus on non-invasive diagnostic methods. This study aims to construct a noninvasive model to predict liver histology for antiviral therapy in chronic hepatitis B (CHB) with alanine aminotransferase (ALT)
Wang, Xiaomei Chi, Xiumei Wu, Ruihong Xu, Hongqin Gao, Xiuzhu Yu, Lei Liu, Longgen Zhang, Mingxiang Tan, Youwen Niu, Junqi
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Published in
Virology Journal
BackgroundSerum hepatitis B virus RNA (HBV RNA) has been reported to be a surrogate marker of intrahepatic cccDNA during nucleos(t)ide analogs therapy. However, in HBeAg-positive patients treated with peg-interferon (peg-IFN), whether HBV RNA is superior to other HBV markers in reflecting cccDNA profile is still unclear.MethodsSerum HBV RNA, HBcrAg...
Chang, Mei-Hwei
Published in
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer
Hepatocellular carcinoma (HCC) is one of the five leading causes of cancer death in human. Hepatitis B virus (HBV) is the most common etiologic agent of HCC in the world. Prevention is the best way to control cancer. There are three levels of liver cancer prevention, i.e., primary prevention by HBV vaccination targeting the general population start...
Tamandjou Tchuem, Cynthia Cotton, Mark Fredric Nel, Etienne Tedder, Richard Preiser, Wolfgang Violari, Avy Bobat, Raziya Hovind, Laura Aaron, Lisa Montepiedra, Grace
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Published in
BMC Pediatrics
BackgroundWhilst much attention is given to eliminating HIV mother-to-child transmission (MTCT), little has been done to ensure the same for hepatitis B virus (HBV) transmission. The introduction of HBV immunization at six weeks of age has reduced HBV horizontal transmission in South Africa. However, in order to eliminate HBV MTCT, further interven...
Suzuki, Yuichi Onuma, Haruno Sato, Risa Sato, Yusuke Hashiba, Akari Maeki, Masatoshi Tokeshi, Manabu Kayesh, Mohammad Enamul Hoque Kohara, Michinori Tsukiyama-Kohara, Kyoko
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Published in
Journal of controlled release : official journal of the Controlled Release Society
The clustered regularly interspaced short palindromic repeats (CRISPR)-associated (Cas) system has considerable therapeutic potential for use in treating a wide range of intractable genetic and infectious diseases including hepatitis B virus (HBV) infections. While non-viral delivery technologies for the CRISPR/Cas system are expected to have clini...
Lee, Hye Won Chon, Young Eun Kim, Beom Kyung Yip, Terry Cheuk-Fung Tse, Yee-Kit Wong, Grace Lai-Hung Wong, Vincent Wai-Sun Chan, Henry Lik-Yuen Ahn, Sang Hoon
Published in
European journal of internal medicine
Whether chronic hepatitis B (CHB) patients during immune-tolerant (IT) phase are at low risk of hepatocellular carcinoma (HCC) is still controversial. We performed a multicenter study to determine their long-term prognosis. Untreated IT group included patients 6 log10IU/mL, and ALT level
Jang, Jeong Won Kim, Jin Seoub Kim, Hye Seon Tak, Kwon Yong Nam, Heechul Sung, Pil Soo Bae, Si Hyun Choi, Jong Young Yoon, Seung Kew Roberts, Lewis R
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Published in
Clinical and molecular hepatology
The role of hepatitis B virus (HBV) integration into the host genome in hepatocarcinogenesis following HBsAg seroclearance remains unknown. The aim of our study was to investigate and characterize HBV integration events in patients with chronic hepatitis B (CHB) who developed hepatocellular carcinoma (HCC) after HBsAg seroclearance. Using probe-bas...
Kayesh, Mohammad Enamul Hoque Amako, Yutaka Hashem, Md Abul Murakami, Shuko Ogawa, Shintaro Yamamoto, Naoki Hifumi, Tatsuro Miyoshi, Noriaki Sugiyama, Masaya Tanaka, Yasuhito
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Published in
Virus research
Chronic hepatitis B virus (HBV) infection constitutes a global health issue with limited current therapeutic efficacy owing to the persistence of viral episomal DNA (cccDNA). The CRISPR/Cas9 system, a newly developed, powerful tool for genome editing and potential gene therapy, requires efficient delivery of CRISPR components for successful therape...
Bawah, Ahmed Tijani Kinanyok, Silas Abaka-Yawson, Albert Mwintumah, Benjamin Ngambire, Lincoln Toamsoma Darko, Richard Hamid, Abdul-Wahab Mawuko
Published in
Journal of community health
Hepatitis B virus (HBV) infection is an infectious disease that is specific to the liver, causing both acute and chronic hepatitis. This study determined the trend of HBV infection among blood donors in the Kpandai District Hospital from January 2014 to December 2018. Retrospective analysis of donor profiles for a period of 5 years was used to asse...
Wang, Yanan Wan, Yu-Jui Yvonne
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors with a low survival rate. The identification of mechanisms underlying the development of HCC helps uncover cellular and molecular targets for the diagnosis, prevention, and treatment of HCC. Golgi protein 73 (GP73) level is upregulated in HCC patients and potentially can be a...