Liang, Xinyuan Liu, Peiyan He, Zonglin Chen, Xin Xiao, Xiaomin
Published in
Clinics and research in hepatology and gastroenterology
Antiviral treatment could block mother-to-child transmission (MTCT) of hepatitis B virus (HBV) effectively. We examined whether maternal use of telbivudine (LdT) could decrease the proportion of CD4+CD25+ regulatory T cells and explored the immunological mechanism. A total of 89 pregnant women with HBsAg positive were enrolled, where 30 pregnant wo...
Zhang, Liangdong Wang, Zichao
Published in
Virology Journal
BackgroundThe present study aims to explore the functions of circular RNA hsa_circ_0004812 in chronic hepatitis B (CHB) and its underlying molecular mechanisms.MethodsThe expression of circular RNA (circRNA)_0004812 was examined using qRT-PCR and Western blot in blood and liver tissues from CHB patients and healthy volunteers. In the in vitro study...
Niizuma, Kuniyasu Ogawa, Yoshikazu Kogure, Takayuki Tominaga, Teiji
Published in
BMC Infectious Diseases
BackgroundHepatitis B virus (HBV) infection is a major public health problem worldwide. More than 2 billion people have been exposed to HBV, and about 257 million individuals are chronic carriers of HBV. HBV reactivation has been increasingly reported in HBV carriers who have undergone immunosuppression or chemotherapy, resulting in mortality. Trea...
Hou, Yixin Zhang, Qianqian Gao, Fangyuan Mao, Dewen Li, Jun Gong, Zuojiong Luo, Xinla Chen, Guoliang Li, Yong Yang, Zhiyun
...
Published in
BMC Gastroenterology
BackgroundThis study aimed to develop prognostic models for predicting 28- and 90-day mortality rates of hepatitis B virus (HBV)-associated acute-on-chronic liver failure (HBV-ACLF) through artificial neural network (ANN) systems.MethodsSix hundred and eight-four cases of consecutive HBV-ACLF patients were retrospectively reviewed. Four hundred and...
Li, Xiaojie Yuan, Mei Song, Lu Wang, Yan
Published in
BMC Medical Genetics
BackgroundThis study was aimed to investigate the regulatory role of microRNA-210 (miRNA-210) on the progression of liver cancer and Hepatitis B virus (HBV)-associated liver cancer.MethodsThe expression of miRNA-210 was detected in liver tissues of HBV-associated cirrhosis and liver cancer, and in HepG2 and HepG2.2.15 cells by qRT-PCR. MiRNA-210 wa...
Mustapha, Garba Umar Ibrahim, Abdulrasul Balogun, Muhammad Shakir Umeokonkwo, Chukwuma David Mamman, Aisha Indo
Published in
BMC Infectious Diseases
BackgroundHepatitis B virus disease is a potentially life-threatening liver infection and a major global health problem. It causes chronic infection and puts people at high risk of death from cirrhosis and liver cancer. WHO estimated 257 million people are living with hepatitis B virus (HBV) infection and in 2015 alone HBV resulted in to 887,000 de...
Guo, Xiaoyan Chen, Dianke Cai, Qingxian Huang, Zhanlian Xu, Wenxiong Peng, Liang Chen, Ping
Published in
BMC Molecular and Cell Biology
BackgroundInterferon-alpha (IFNα) is a first-line treatment option for chronic hepatitis B virus (HBV) infection, but the severe systemic side-effects limited its clinical application. Interferon-lambda (IFNλ) with comparable antiviral activity and less toxic side-effects is thought to be a good alternative interferon to IFNα. Additionally, the gen...
Xue, Xiulan Liao, Wei Xing, Yugang
Published in
Infectious Agents and Cancer
ObjectiveTo evaluate the difference between hepatitis B virus related hepatocellular carcinoma (HBV-HCC) and non-HBV non-HCV hepatocellular carcinoma (NBNC-HCC) patients based on clinical features and prognosis.MethodsA total of 175 patients with HCC were enrolled. Patients’ characteristics were extracted from medical records. Among them, 107 patie...
Kawambwa, Rahim H. Majigo, Mtebe V. Mohamed, Ahmed A. Matee, Mecky I.
Published in
BMC Public Health
BackgroundTanzania has witnessed a significant decrease in the prevalence of human immunodeficiency virus (HIV) and viral hepatitis in the general population attributed to several interventional measures. It is uncertain whether this decline has also occurred among people who inject drugs (PWID). This study aimed to determine the seroprevalence of ...
Yang, Tian Hu, Lun-Yang Li, Zhen-Li Liu, Kai Wu, Han Xing, Hao Lau, Wan Yee Pawlik, Timothy M Zeng, Yong-Yi Zhou, Ya-Hao
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Published in
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
The incidence of hepatocellular carcinoma (HCC) in non-alcoholic fatty liver disease (NAFLD) is increasing worldwide. Higher perioperative risks may be anticipated due to underlying steatohepatitis, while long-term outcomes after liver resection are unknown. We sought to investigate outcomes after liver resection for NAFLD-HCC versus hepatitis B vi...
