Abiye, Siwule Yitayal, Mezgebu Abere, Giziew Adimasu, Asefa
Published in
BMC Health Services Research
BackgroundHepatitis B virus (HBV) infection is a global public health problem. The burden of the disease is high in low and middle income countries like Ethiopia. However, for highly vulnerable groups such as health professionals, vaccination coverage is a major issue in the developing countries where health professionals are expected to pay for va...
Yazie, Teshiwal Deress Tebeje, Mekonnen Girma
Published in
BMC Infectious Diseases
BackgroundHepatitis B virus is one of the major public health concerns globally. It is highly infectious and can be transmitted from person to person through vertically or horizontally via contaminated body fluids. Despite the provision of an effective vaccine, it remains a major problem worldwide, particularly among the developing countries.Method...
Sun, Suofeng Li, Yuan Han, Shuangyin Jia, Hongtao Li, Xiuling Li, Xiaofang
Published in
BMC Medical Genomics
BackgroundHepatocellular carcinoma (HCC) is one of the most common cancers worldwide, especially in East Asia. Even with the progress in therapy, 5-year survival rates remain unsatisfied. Chronic infection with the hepatitis B virus (HBV) or hepatitis C virus (HCV) has been epidemiologically associated with HCC and is the major etiology in the East...
Soliman, Gamal Elzalabany, Mahmoud S. Hassanein, Tarek Miller, F. DeWolfe
Published in
BMC Public Health
BackgroundIt is well documented that Egypt has the highest prevalence of hepatitis C virus (HCV) infection in the world. The recent development of highly effective direct acting antiviral drugs (DAAs), has opened the possibility of treating and curing HCV infection in the Egyptian population on a large scale.MethodsA screening demonstration project...
Yuan, Yifei Zhao, Kaitao Yao, Yongxuan Liu, Canyu Chen, Yingshan Li, Jing Wang, Yun Pei, Rongjuan Chen, Jizheng Hu, Xue
...
Published in
Antiviral research
Hepatitis B virus (HBV) infection remains an important public health problem worldwide. Covalently closed circular DNA (cccDNA) exhibits as an individual minichromosome and is the molecular basis of HBV infection persistence and antiviral treatment failure. In the current study, we demonstrated that histone deacetylase 11 (HDAC11) inhibits HBV tran...
Jiang, Pei-Xue Mao, Ri-Cheng Dong, Min-Hui Yu, Xue-Ping Xun, Qi Wang, Jin-Yu Jing, Li Qiang, Deng Zhang, Ji-Ming
Published in
Hepatobiliary & pancreatic diseases international : HBPD INT
Hepatitis B virus covalently closed circular DNA (HBV cccDNA) is an important biomarker of hepatitis B virus infection. However, the current methods are not specific and sensitive. The present study aimed to develop a specific and sensitive assay method for the quantification of HBV cccDNA. Exonuclease I (Exo I) & Exonuclease III (Exo III) and spec...
huang, si-xin mou, jun-fei luo, qin qing-hu, mo zhou, xian-li huang, xiao qing, xu tan, xiang-duan chen, xu liang, cheng-qin
...
the compound was identified as esculetin by hydrogen and carbon spectroscopy. Its anti-hepatitis B virus (HBV) activity was investigated in vitro and in vivo. In the human hepatocellular liver carcinoma 2.2.15 cell line (HepG2.2.15) transfected with HBV, esculetin effecting inhibited the expression of the HBV antigens and HBV DNA in vitro. Esculeti...
Foroghi Biland, Luca Ferrari, Ludovica Malagnino, Vincenzo Teti, Elisabetta Cerva, Carlotta Gentile, Adele Aragri, Marianna Salpini, Romina Svicher, Valentina Andreoni, Massimo
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Published in
Journal of Medical Case Reports
BackgroundAlthough several cases of hepatitis B virus reactivation have been described in patients with a history of hepatitis B virus infection while undergoing treatment for hepatitis C virus infection with direct acting antivirals, the question of whether hepatitis B virus surface antigen immune-escape mutations might play a role has not been ad...
Li, Feng-Cai Fan, Yu-Chen Li, Yue-Kai Wang, Kai
Published in
Virology Journal
Background and aimsHepatitis B virus-related decompensated cirrhosis is difficult to cure but has a high readmission rate due to multiple complications. Our aim was to investigate the diagnostic potential value of plasma diamine oxidase (DAO) for 6-month readmission of patients with HBV-related decompensated cirrhosis.MethodsA total of 135 patients...
Vandenbossche, Joris Jessner, Wolfgang van den Boer, Maarten Biewenga, Jeike Berke, Jan Martin Talloen, Willem De Zwart, Loeckie Snoeys, Jan Yogaratnam, Jeysen
Published in
Advances in therapy
Hepatitis B viral capsid assembly is an attractive target for new antiviral treatments. JNJ-56136379 (JNJ-6379) is a potent capsid assembly modulator in vitro with a dual mode of action. In Part 1 of this first-in-human study in healthy adults, the pharmacokinetics (PK), safety and tolerability of JNJ-6379 were evaluated following single ascending ...
