Lefebvre, Thierry Hébert, Mélanie Bilodeau, Laurent Sebastiani, Giada Cerny, Milena Olivié, Damien Gao, Zu-Hua Sylvestre, Marie-Pierre Cloutier, Guy Nguyen, Bich N
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Published in
European radiology
To evaluate the diagnostic performance of intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) for grading hepatic inflammation. In this retrospective cross-sectional dual-center study, 91 patients with chronic liver disease were recruited between September 2014 and September 2018. Patients underwent 3.0-T MRI examinations within 6 ...
Shiha, Gamal Soliman, Reham Elbasiony, Mohamed Darwish, Noureldien H. E. Mousa, Shaker A.
Published in
Scientific Reports
The new anti-hepatitis C virus (HCV) molecules improve treatment regimens and outcomes, but there are drawbacks. New combinations should target the HCV infectious cycle and be effective against all HCV genotypes. We developed the novel formulation Catvira, composed of epigallocatechingallate (EGCG) + sofosbuvir + ribavirin. Here, we compared Catvir...
Nakanishi, Tomoko Maekawa, Aya Suzuki, Mariko Tabata, Hirotaka Sato, Kumiko Mori, Mai Saito, Izumu
Published in
Scientific Reports
Simultaneous expression of multiplex guide RNAs (gRNAs) is valuable for knockout of multiple genes and also for effective disruption of a gene by introducing multiple deletions. We developed a method of Tetraplex-guide Tandem for construction of cosmids containing four and eight multiplex gRNA-expressing units in one step utilizing lambda in vitro ...
Patrinely, J. Randall Jr. McGuigan, Ben Chandra, Sunandana Fenton, Sarah E. Chowdhary, Akansha Kennedy, Lucy B. Mooradian, Meghan J. Palmeri, Marisa Portal, Daniella Horst, Sara N.
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Published in
Oncoimmunology
Immune checkpoint inhibitors (ICI) predispose patients to immune-related adverse events (irAEs). Although hepatitis is a potentially lethal toxicity, the timing and outcomes have not been well described. In this retrospective study, patients from six international institutions were included if they were treated with ICIs and developed immune-relate...
Zhou, Li-Na Dong, Shao-Shao Zhang, Sheng-Ze Huang, Wen
Published in
World Journal of Clinical Cases
BACKGROUND Fish gallbladder has long been used as a folk remedy in Asian countries. Multiple organ damage after ingestion of fish gallbladder resulting in near mortality has been known to us. Here, we describe a case of acute renal failure (ARF) and hepatitis due to grass carp gallbladder poisoning and review the literature. CASE SUMMARY A previous...
Li, Peng Liang, Xi Xu, Shan Xiong, Ye Huang, Jianrong
Published in
Scientific Reports
We aim to determine the impact of an artificial liver support system (ALSS) treatment before liver transplantation (LT), and identify the prognostic factors and evaluate the predictive values of the current commonly used ACLF prognostic models for short-term prognosis after LT. Data from 166 patients who underwent LT with acute-on-chronic liver fai...
Vespa, Edoardo Pugliese, Nicola Colapietro, Francesca Aghemo, Alessio
Published in
Techniques and Innovations in Gastrointestinal Endoscopy
SARS-CoV-2 is the virus responsible for COVID-19, whose clinical spectrum ranges widely, both in terms of severity and multi-organicity. SARS-CoV-2 mainly involves the respiratory tract, causing from a flu-like syndrome to interstitial pneumonia and acute respiratory distress syndrome. Although its entry receptor, angiotensin-converting-enzyme 2, i...
Doyle, Erin H. Aloman, Costica El-Shamy, Ahmed Eng, Francis Rahman, Adeeb Klepper, Arielle L. Haydel, Brandy Florman, Sander S. Fiel, M. Isabel Schiano, Thomas
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Published in
Scientific Reports
Viral hepatitis leads to immune-mediated liver injury. The rate of disease progression varies between individuals. We aimed to phenotype immune cells associated with preservation of normal liver function during hepatitis C virus (HCV) infection. Clinical data and specimens were obtained from 19 HCV-infected patients undergoing liver transplantation...
Kong, Lingxiang Wei, Guo Lv, Tao Jiang, Li Yang, Jian Zhao, Yong Yang, Jiayin
Published in
Scientific Reports
The surgical treatment and transcatheter arterial chemoembolization (TACE) rate of human immunodeficiency virus (HIV)-infected hepatocellular carcinoma (HCC) patients is relatively low in West China. For various reasons, most patients do not receive timely surgical treatment. Upon transfer to an infectious disease centralized hospital, they were al...
Wagner, Katherine Zhong, Yuna Teshale, Eyasu White, Kirsten Winstanley, Erin L Hettema, Jennifer Thornton, Karla Bisztray, Birgitta Fiuty, Philip Page, Kimberly
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Published in
Drug and alcohol dependence
We assessed prevalence and correlates for hepatitis C virus (HCV) infection in young adult people who inject drugs (PWID) in rural New Mexico, where opioid use has been historically problematic. Participants were 18-29 years old with self-reported injection drug use in the past 90 days. We conducted testing for HCV antibodies (anti-HCV) and HCV rib...
