Wang, Dapeng He, Rui Song, Qian Diao, Heng Jin, Ying Zhang, Aihua
Published in
Biological trace element research
Previous studies, including our own, have demonstrated that arsenic exposure can induce liver fibrosis, while the underlying mechanism remains unclear and there is currently no effective pharmacological intervention available. Recent research has demonstrated that vitamin D supplementation can ameliorate liver fibrosis caused by various etiologies,...
Xie, Li Chen, Hui Zhang, Li Ma, Yue Zhou, Yuan Yang, Yong-Yu Liu, Chang Wang, Yu-Li Yan, Ya-Jun Ding, Jia
...
Published in
Clinical and molecular hepatology
Cholestatic liver diseases including primary biliary cholangitis (PBC) are associated with active hepatic fibrogenesis, which ultimately progresses to cirrhosis. Activated hepatic stellate cells (HSCs) are the main fibrogenic effectors in response to cholangiocyte damage. JCAD regulates cell proliferation and malignant transformation in nonalcoholi...
Choi, Haena Oh, Daehyun Kim, Hyeon-Ji Chambugong, Melody Kim, Mi-Hyun Lee, Mi-Ock Park, Hyeung-Geun
Published in
Life sciences
Hepatic fibrosis is a dynamic process characterized by the net accumulation of an extracellular matrix resulting from chronic liver injury such as nonalcoholic steatohepatitis. Activation of hepatic stellate cells (HSCs) plays a role in transdifferentiation of quiescent cells into fibrogenic myofibroblasts. We aimed to examine the function of retin...
Raza, Sana Rajak, Sangam Singh, Rajani Zhou, Jin Sinha, Rohit A Goel, Amit
Published in
World Journal of Hepatology
Autophagy, a cellular degradative process, has emerged as a key regulator of cellular energy production and stress mitigation. Dysregulated autophagy is a common phenomenon observed in several human diseases, and its restoration offers curative advantage. Non-alcoholic fatty liver disease (NAFLD), more recently renamed metabolic dysfunction-associa...
Liao, Xin Luo, Yilin Gu, Fang Song, Wen Nie, Xin Yang, Qin
Published in
Hepatology international
Cleavage of fibronectin type III domain-containing protein 5 (FNDC5), a membrane-bound precursor protein, would cleave into a myokine, irisin, which is also expressed in the liver. FNDC5/Irisin has been reported to play a critical role in maintaining glucose and lipid homeostasis in the liver and in combating liver fibrosis. Recently, several studi...
Xie, Zhongping Zhou, Yu Lin, Min Huang, Caihua
Published in
Amino acids
Hepatic stellate cell (HSC) activation is the key process in hepatic fibrosis (HF) development. Targeted death of HSCs could be effective in the prevention and treatment of HF. Phosphatidylethanolamine-binding protein (PEBP)1 can trigger ferroptosis by mediating peroxide production, but how it modulates HSC ferroptosis is not known. We screened nat...
Ruiz de Galarreta, Marina Arriazu, Elena Pérez de Obanos, María P Ansorena, Eduardo Iraburu, María J
Published in
Journal of physiology and biochemistry
Ocoxin is a nutritional supplement that has been shown to exert antioxidant and immunomodulatory responses in patients with chronic hepatitis C. The present work aimed to determine the effects of Ocoxin on activated hepatic stellate cells (HSC), the cell type mainly responsible for collagen deposition in the fibrotic liver. Ocoxin was found to redu...
Lu, Hongjian Zhang, Ronghua Zhang, Shukun Li, Yufeng Liu, Yankun Xiong, Yanan Yu, Xiaohan Lan, Tao Li, Xin Wang, Meimei
...
Published in
International immunopharmacology
Exosomes have been implicated in inflammation-related diseases, such as hepatic fibrosis (HF) and renal fibrosis, via transferring bioactive cargoes to recipient cells. This study aimed to investigate the possible effect of hepatic stellate cell (HSC)-derived exosomes on the initiation and development of HF by delivering microRNA (miR)-199a-5p. In ...
Xing, Kai Wu, Yue Gao, Fei Dai, Yupeng Guan, Chun Tong, Yu Gao, Yi Wang, Cong Zhang, Can
Published in
European journal of medicinal chemistry
Hepatic fibrosis poses a significant threat to human health due to excessive extracellular matrix (ECM) deposition leading to liver function damage. Ligand-activated vitamin D receptor (VDR) has been identified as an effective target for hepatic fibrosis, reducing ECM by inhibiting hepatic stellate cell (HSC) activation. Here, a series of novel dip...
Hu, Guang-Xian Xie, Xiao-Fen Yuan, Tian-Hong Shuai, Min Zhang, Jin-Juan Zhou, Dan Chen, Jiu-Qiong Ran, Miao Wang, Lan Yong-Li,
...
Published in
Fitoterapia
Liver fibrosis refers to a reversible event of repair and reconstruction following injury due to various etiologies, and its continuous development will lead to cirrhosis and liver cancer. Abnormal alterations in intestinal microbiota can hasten the development of hepatic fibrosis and damage. Veronicastrum latifolium (Hemsl.) Yamazaki (VLY) is a cl...
