Tsai, Yu-Wei Zhou, Zhuhuang Gong, Cihun-Siyong Alex Tai, Dar-In Cristea, Anca Lin, Yu-Ching Tang, Ya-Chun Tsui, Po-Hsiang
Published in
Ultrasound in medicine & biology
Acoustic structure quantification (ASQ) based on the analysis of ultrasound backscattered statistics has been reported to detect liver fibrosis without significant hepatic steatosis. This study proposed using ultrasound parametric imaging based on the parameter α of the homodyned K (HK) distribution for staging liver fibrosis in patients with signi...
Lin, Yu-Chun Lu, Hsu-Feng Chen, Jui-Chieh Huang, Hsiu-Chen Chen, Yu-Hsin Su, Yen-Shuo Tung, Chien-Yi Huang, Cheng
Published in
BMC Complementary Medicine and Therapies
BackgroundObesity and its associated diseases have become a major world-wide health problem. Purple-leaf Tea (Camellia sinensis L.) (PLT), that is rich of anthocyanins, has been shown to have preventive effects on obesity and metabolic disorders. The intestinal microbiota has been shown to contribute to inflammation, obesity, and several metabolic ...
Lin, Minjie Long, Jungke Li, Wenbo Yang, Chenxuan Loughran, Patricia O’Doherty, Robert Billiar, Timothy R. Deng, Meihong Scott, Melanie J.
Published in
Molecular Medicine
BackgroundCirculating high-mobility group box 1 (HMGB1) plays important roles in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Intracellular HMGB1 is critical for the biology of hepatocytes. However, the intracellular role of HMGB1 in hepatocellular steatosis is unknown. Therefore, we aimed to investigate the role of hepatocyte-spec...
Edmunds, Lia R Xie, Bingxian Mills, Amanda M Huckestein, Brydie R Undamatla, Ramya Murali, Anjana Pangburn, Martha M Martin, James Sipula, Ian Kaufman, Brett A
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Published in
Molecular metabolism
PARKIN is an E3 ubiquitin ligase that regulates mitochondrial quality control through a process called mitophagy. Recent human and rodent studies suggest that loss of hepatic mitophagy may occur during the pathogenesis of obesity-associated fatty liver and contribute to changes in mitochondrial metabolism associated with this disease. Whole-body Pr...
Franceschetti, Lorenzo Bonomini, Francesca Rodella, Luigi Fabrizio Rezzani, Rita
Published in
Current molecular medicine
Non-alcoholic fatty liver disease is a chronic metabolic disorder representing the most common cause of chronic liver disease in western civilization and one of the main causes of cirrhosis with a significant impact on all-cause mortality in the most advanced phases. It is characterized by hepatic fat accumulation in the absence of significant etha...
Guo, Wen Lu, Jing Qin, Pei Li, Xiaona Zhu, Wenfang Wu, Juan Xu, Nianzhen Zhang, Qun
Published in
Lipids in Health and Disease
BackgroundThe triglyceride-glucose index (TyG) is a reliable predictor of non-alcoholic fatty liver disease (NAFLD). Its association with the severity of hepatic steatosis and liver fibrosis in NAFLD is poorly understood. This study evaluated the relationship between these factors in NAFLD.MethodsA total of 4784 participants who underwent ultrasono...
Homayounieh, Fatemeh Saini, Sanjay Mostafavi, Leila Doda Khera, Ruhani Sühling, Michael Schmidt, Bernhard Singh, Ramandeep Flohr, Thomas Kalra, Mannudeep K
Published in
International journal of computer assisted radiology and surgery
Radiomics help move cross-sectional imaging into the domain of quantitative imaging to assess the lesions, their stoma as well as in their temporal monitoring. We applied and assessed the accuracy of radiomics for differentiating healthy liver from diffuse liver diseases (cirrhosis, steatosis, amiodarone deposition, and iron overload) on non-contra...
Park, Ji-Eun Jeong, Yeon Jae Kim, Hye Young Yoo, Young Hyun Lee, Kwang Sik Yang, Won Tae Kim, Doh Hoon Kim, Jong-Min
Published in
Development & Reproduction
Many benefits of silk protein fibroin (SPF) have been suggested in biomedical applications; and notably, significant SPF effects have been observed for metabolic syndromes that are directly linked to insulin resistance, such as type 2 diabetes mellitus (T2DM). Based on our previous findings, we believe that SPF from spiders exhibits outstanding glu...
Yanagita, Teruyoshi Tsuge, Keisuke Koga, Misato Inoue, Nao Nagao, Koji
Published in
Archives of biochemistry and biophysics
Nonalcoholic fatty liver disease (NAFLD) is emerging as the most common liver disease in industrialized countries. Because hepatic steatosis is an early pathogenesis of NAFLD, the discovery of food components that could ameliorate hepatic steatosis is of interest. Susabinori (Pyropia yezoensis) is recognized as one of the most delicious edible brow...
Zhao, Qiong-Ya Ge, Ling-Hong Zhang, Kun Chen, Hai-Feng Zhan, Xin-Xin Yang, Yue Dang, Qing-Lin Zheng, Yi Zhou, Huai-Bin Lyu, Jian-Xin
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Published in
Zoological research
Metabolic dysfunction-associated fatty liver disease (MAFLD) is characterized by deregulated hepatic lipid metabolism; however, the association between MAFLD development and mitochondrial dysfunction has yet to be confirmed. Herein, we employed high-resolution respirometry, blue native polyacrylamide gel electrophoresis-based in-gel activity measur...
