Vacca, Michele Leslie, Jack Virtue, Samuel Lam, Brian YH Govaere, Olivier Tiniakos, Dina Snow, Sophie Davies, Susan Petkevicius, Kasparas Tong, Zhen
...
Non-alcoholic steatohepatitis (NASH) is characterized by lipotoxicity, inflammation and fibrosis, ultimately leading to end-stage liver disease. The molecular mechanisms promoting NASH are poorly understood and treatment options are limited. Here, we demonstrate that hepatic expression of Bone Morphogenetic Protein 8B (BMP8B), a member of the TGFβ/...
Tao, Le Ma, Wenting Wu, Liu Xu, Mingyi Yang, Yanqin Zhang, Wei Sha, Wenjun Li, Hongshan Xu, Jianrong Feng, Rilu
...
OBJECTIVE:Although glial cell line-derived neurotrophic factor (GDNF) is a member of the transforming growth factor-β superfamily, its function in liver fibrosis has rarely been studied. Here, we investigated the role of GDNF in hepatic stellate cell (HSC) activation and liver fibrosis in humans and mice. DESIGN:GDNF expression was examined in live...
Tutusaus, Anna de Gregorio, Estefanía Cucarull, Blanca Cristóbal, Helena Aresté, Cristina Graupera, Isabel Coll, Mar Colell, Anna Gausdal, Gro Lorens, James B
...
Published in
Cellular and molecular gastroenterology and hepatology
GAS6 signaling, through the TAM receptor tyrosine kinases AXL and MERTK, participates in chronic liver pathologies. Here, we addressed GAS6/TAM involvement in Non-Alcoholic SteatoHepatitis (NASH) development. GAS6/TAM signaling was analyzed in cultured primary hepatocytes, hepatic stellate cells (HSC) and Kupffer cells (KCs). Axl-/-, Mertk-/- and w...
Dobie, Ross Wilson-Kanamori, John R Henderson, Beth EP Smith, James R Matchett, Kylie P Portman, Jordan R Wallenborg, Karolina Picelli, Simone Zagorska, Anna Pendem, Swetha V
...
Chinnadurai, Raghavan Sands, Jenna Rajan, Devi Liu, Xiao Arafat, Dalia Das, Rahul Anania, Frank A Gibson, Greg Kisseleva, Tatiana Galipeau, Jacques
...
Published in
Stem cells (Dayton, Ohio)
Defining the immune physiology of culture-adapted mesenchymal stromal cells (MSCs) derived from distinct tissue compartments informs their potential utility as pharmaceuticals. Here, we have investigated the comparative immune plasticity of MSCs and hepatic stellate cells (HeSCs) isolated from human and murine bone marrow (BM) and liver, respective...
Ogawa, Masahiro Kanda, Tatsuo Higuchi, Teruhisa Takahashi, Hiroshi Kaneko, Tomohiro Matsumoto, Naoki Nirei, Kazushige Yamagami, Hiroaki Matsuoka, Shunichi Kuroda, Kazumichi
...
Published in
International journal of medical sciences
The prevalence of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) is increasing worldwide. Several effective drugs for these diseases are now in development and under clinical trials. It is important to reveal the mechanism of the development of NAFLD and NASH. We investigated the role of arrestin domain-containin...
Baglieri, Jacopo Brenner, David A Kisseleva, Tatiana
Hepatocellular carcinoma (HCC) is one of the most aggressive types of cancer and lacks effective therapeutic approaches. Most HCC develops in the setting of chronic liver injury, hepatic inflammation, and fibrosis. Hepatic stellate cells (HSCs) and cancer-associated fibroblasts (CAFs) are key players in liver fibrogenesis and hepatocarcinogenesis, ...
Tang, Xuechan Xie, Xiaoli Wang, Xin Wang, Yan Jiang, Xiaoyu Jiang, Huiqing
Published in
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Background Piwi-interacting RNA (piRNA) is the largest class of small non-coding RNA, which has also been identified in somatic tissues, and aberrant expression of piRNAs in tumor tissues may be implicated in carcinogenesis. piR-823 is increased in liver cirrhosis and hepatocellular carcinoma (HCC). However, there is no report on the function of pi...
Cortes, E Lachowski, D Rice, A Thorpe, SD Robinson, B Yeldag, G Lee, DA Ghemtio, L Rombouts, K Del Río Hernández, AE
...
Tamoxifen has been used for many years to target estrogen receptor signalling in breast cancer cells. Tamoxifen is also an agonist of the G protein-coupled estrogen receptor (GPER), a GPCR ubiquitously expressed in tissues that mediates the acute response to estrogens. Here we report that tamoxifen promotes mechanical quiescence in hepatic stellate...
Zhang, Huan Lin, Yajun Zhen, Yongzhan Hu, Gang Meng, Xu Li, Xingxin Men, Xiuli
Published in
The American journal of Chinese medicine
To investigate the therapeutic effect of glycyrrhizin arginine salt on rat cholestatic cirrhosis, we subjected male Sprague Dawley rats to common bile duct ligation for 14 days and treated them with distilled water (model group), arginine, or a low or high dose of glycyrrhizin arginine salt by gavage. A sham-operated group was used as a control gro...