Chen, Zheng Yao, Jinpeng Zhao, Jiulong Wang, Shige
Published in
International journal of biological macromolecules
Currently, hydrogels are widely studied for wound dressings. However, wound healing is often hindered by bacterial infection. In this study, in situ cross-linked carboxymethyl chitosan (CMCS)/oxidized dextran (OD)/poly-γ-glutamic acid (γ-PGA) (COP) hydrogel was prepared for antimicrobial and hemostasis of diffuse wounds. In the COP hydrogel, γ-PGA ...
Xu, Jie Fang, Huan Su, Ya Kang, Yue Xu, Deli Cheng, Yuen Yee Nie, Yi Wang, Hong Liu, Tianqing Song, Kedong
...
Published in
International journal of biological macromolecules
Currently, a suitable bioink for 3D bioprinting and capable of mimicking the microenvironment of native skin and preventing bacterial infection remains a major challenge in skin tissue engineering. In this study, we prepared a tissue-specific extracellular matrix-based bioink, and dECM/Gel/QCS (dGQ) 3D scaffold assembling with poly(ionic liquid)s (...
Cha, Boram Noh, Jin Hee Ahn, Ji Yong Lee, Jun Su Kim, Ga Hee Na, Hee Kyong Jung, Kee Wook Lee, Jeong Hoon Kim, Do Hoon Choi, Kee Don
...
Published in
Digestive diseases and sciences
In the efforts toward reducing bleeding-related mortality, it is crucial to determine the risk factors for rebleeding after endoscopic hemostasis in benign peptic ulcer (BPU). Between 2013 and 2017, the medical records of 864 BPU patients were selected from 5076 who had undergone emergency endoscopy for suspected upper gastrointestinal bleeding. Pa...
Girish, Aditya Jolly, Ketan Alsaadi, Nijmeh de la Fuente, Maria Recchione, Arielle An, Ran Disharoon, Dante Secunda, Zachary Raghunathan, Shruti Luc, Norman F
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Published in
ACS nano
Severe hemorrhage associated with trauma, surgery, and congenital or drug-induced coagulopathies can be life-threatening and requires rapid hemostatic management via topical, intracavitary, or intravenous routes. For injuries that are not easily accessible externally, intravenous hemostatic approaches are needed. The clinical gold standard for this...
Lee, Michael Fook-Ho Ananda, Arjuna
Published in
Auris, nasus, larynx
Complications of endoscopic sinus/nasal turbinate surgery include postoperative hemorrhage, synechiae formation, and poor wound healing. Our primary objectives were to evaluate whether a topical hydrogel based on self-assembling RADA16 peptides: i) reduces bleeding and synechiae formation, and ii) supports wound healing, using a sheep nasal surgery...
Ouyang, Xiao-Kun Zhao, Lijuan Jiang, Fangyuan Ling, Junhong Yang, Li-Ye Wang, Nan
Published in
Carbohydrate polymers
Porous microsphere hemostatic materials, which possess rapid hemostatic, antibacterial, and wound healing-promotion properties, have key advantages over hemostatic dressings with a single hemostatic function. Using rod-shaped cellulose nanocrystals as the supporting framework, sodium alginate/cellulose nanocrystal porous microspheres (SA/CNC) were ...
Chaudhary, Rahul Sharma, Tushar Tantry, Udaya S Asgar, Juzer Ali Kundan, Parshotam Duhan, Sanchit Gill, Haroon Singh, Arvind Alasadi, Yazan Gurbel, Paul A
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Published in
Journal of thrombosis and thrombolysis
Circadian fluctuations in thrombogenicity and hemostasis play a role in acute cardiovascular thrombotic events occurring in the early morning hours. There is a lack of data assessing thrombogenicity, platelet function, and hemodynamics to investigate diurnal variations in a high cardiovascular risk population. This was an exploratory, single-center...
Tirotta, Christopher F Lagueruela, Richard G Gupta, Apeksha Salyakina, Daria Aguero, David Ojito, Jorge Kubes, Kathleen Hannan, Robert Burke, Redmond P
Published in
Pediatric cardiology
The objective of this study was to determine whether treatment with human fibrinogen concentrate decreases the need for component blood therapy and blood loss in neonate and infant patients undergoing cardiopulmonary bypass. Pediatric patients (N = 30) undergoing elective cardiac surgery were randomized to receive human fibrinogen concentrate or pl...
Cao, Shujun Li, Qiujing Zhang, Shukun Liu, Zhuochen Lv, Xiaoyu Chen, Jingdi
Published in
International journal of biological macromolecules
Massive hemorrhage caused by accident or surgery is a major factor in accidental death. In addition, bacterial infection is also an important threat after bleeding. Cryogels with interpenetrating macroporous structures pose great application prospects in rapid hemostasis and infected wound repair. In this study, cryogels with different pore size ar...
Vandevelde, Arne Chayoua, Walid de Laat, Bas Moore, Gary W Musiał, Jacek Zuily, Stéphane Wahl, Denis Devreese, Katrien M J
Published in
Journal of thrombosis and haemostasis : JTH
Diagnosis of antiphospholipid syndrome (APS) requires persistent presence of lupus anticoagulant (LAC), anticardiolipin (aCL) IgG/IgM, or anti-β2 glycoprotein I (aβ2GPI) IgG/IgM antibodies. Other antiphospholipid antibodies (aPL) such as antiphosphatidylserine/prothrombin antibodies (aPS/PT) are promising in assessment of thrombotic APS (TAPS). To ...