Aka, Ibrahim Basar Ozturk, Caglar Lazoglu, Ismail
Published in
SN Applied Sciences
In the design of rotary blood pumps, the optimization of design parameters plays an essential role in enhancing the hydrodynamic performance and hemocompatibility. This study investigates the influence of the volute tongue angle as a volute geometric parameter on the hemodynamic characteristics of a blood pump. A numerical investigation on five dif...
Szajek, Katarzyna Kajdi, Marie-Elisabeth Luyckx, Valerie A. Fehr, Thomas Hans Gaspert, Ariana Cusini, Alexia Hohloch, Karin Grosse, Philipp
Published in
BMC Nephrology
BackgroundAcute kidney injury (AKI) associated with severe coronavirus disease 19 (COVID-19) is common and is a significant predictor of morbidity and mortality, especially when dialysis is required. Case reports and autopsy series have revealed that most patients with COVID-19 – associated acute kidney injury have evidence of acute tubular injury ...
Xu, Huan-Hua Jiang, Zhen-Hong Huang, Cong-Shu Sun, Yu-Ting Xu, Long-Long Tang, Xiang-Ling Tan, Hong-Ling Ma, Zeng-Chun Gao, Yue
Published in
Chinese Medicine
BackgroundOPD and OPD' are the two main active components of Ophiopogon japonicas in Shenmai injection (SMI). Being isomers of each other, they are supposed to have similar pharmacological activities, but the actual situation is complicated. The difference of hemolytic behavior between OPD and OPD' in vivo and in vitro was discovered and reported b...
Schöps, Malte Groß-Hardt, Sascha H. Schmitz-Rode, Thomas Steinseifer, Ulrich Brodie, Daniel Clauser, Johanna C. Karagiannidis, Christian
Published in
Journal of Translational Medicine
BackgroundTreating severe forms of the acute respiratory distress syndrome and cardiac failure, extracorporeal membrane oxygenation (ECMO) has become an established therapeutic option. Neonatal or pediatric patients receiving ECMO, and patients undergoing extracorporeal CO2 removal (ECCO2R) represent low-flow applications of the technology, requiri...
Bahr, Timothy M. Knudsen, Mari C. Lozano-Chinga, Michell Agarwal, Archana M. Meznarich, Jessica A. Ohls, Robin K. Christensen, Robert D.
Published in
Biomedicine Hub
Infantile pyknocytosis is a rare, self-limited, hemolytic condition of unknown pathogenesis. It is diagnosed when a neonate with Coombs-negative hemolytic anemia has abundant pyknocytes and a characteristic clinical course after other hemolytic disorders has been excluded. Previous reports suggest that transfusions might be avoidable in this condit...
Langer, Arielle L. Scigliano, Eileen
Published in
MedEdPORTAL : the Journal of Teaching and Learning Resources
Introduction This team-based learning (TBL) exercise focused on hemolysis and hemoglobin structure and function. The goal was to emphasize content that directly impacts clinical practice, but obliges students to understand underlying pathophysiology. The readiness assurance test (RAT) covers oxygen affinity, diagnosing hemolysis, inherited causes o...
Khan, Anam Sajjad Ud Din, Fakhar Ali, Zakir Bibi, Maryam Zahid, Fatima Zeb, Alam Mujeeb-Ur-Rehman, Khan, Gul Majid
Published in
International journal of pharmaceutics
The purpose of this study was to enhance the anti-leishmanial efficacy of miltefosine (MTF) and reduce its toxic effects by loading it into nanostructured lipid carriers (NLCs). Micro-emulsion technique was used to prepare MTF-loaded NLCs. The optimized NLCs were characterized in terms of various physicochemical parameters including particle size, ...
Obeidat, Khaldun Yassin, Mohamed A.
Published in
Dubai Medical Journal
During the pandemic of COVID-19, which started in December 2019, hydroxychloroquine, the drug which was first introduced as antimalarial medication, was widely used to treat this new viral infection, and it was reported in the literature as a safe drug for use in patients with G6PD deficiency; here, we report a 64-year-old male who was started on h...
Kumbhar, Popat S. Sakate, Asmita M. Patil, Onkar B. Manjappa, Arehalli S. Disouza, John I.
Published in
Journal of the Egyptian National Cancer Institute
BackgroundPodophyllotoxin (PPT) is a naturally occurring compound obtained from the roots of Podophyllum species, indicated for a variety of malignant tumors such as breast, lung, and liver tumors. This toxic polyphenol (PPT) exhibited significant activity against P-glycoprotein (P-gp) mediated multidrug-resistant (MDR) cancer cells. However, extre...
Yamane, Takashi Adachi, Kazuki Kosaka, Ryo Maruyama, Osamu Nishida, Masahiro
Published in
Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs
A suitable index is needed for hemolysis tests that use low-flow pumps, such as pediatric blood pumps or blood purification pumps. To create such an index, the present study investigates the change of plasma-free hemoglobin in the pump circuit with time and the change of the hemolysis rate with flow rate and impeller rotational speed. The results s...
