Cacciatore, Carlotta Baudet, Mathilde Jean, Estelle Presente, Simona Para, Marylou Sonneville, Romain Arangalage, Dimitri Ait Abdallah, Nassim Sicre de Fontbrune, Flore Prata, Pedro Henrique
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Systemic sclerosis (SSc) is a rare autoimmune disease (AD), characterised by early diffuse vasculopathy, activation of the immune response and progressive skin and internal organ fibrosis. In severe progressive diffuse SSc (dSSc), autologous hematopoietic stem cell transplantation (aHSCT) improves survival, despite its own risk of complications and...
Gulec Koksal, Zeynep Bilgic Eltan, Sevgi Topyildiz, Ezgi Sezer, Ahmet Keles, Sevgi Celebi Celik, Figen Ozhan Kont, Aylin Gemici Karaaslan, Betul Sefer, Asena Pinar Karali, Zuhal
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Published in
The journal of allergy and clinical immunology. In practice
Major histocompatibility complex class II deficiency, a combined immunodeficiency, results from loss of HLA class II expression on antigen-presenting cells. Currently, hematopoietic stem cell transplantation stands as the sole curative approach, although factors influencing patient outcomes remain insufficiently explored. To elucidate the clinical,...
Shu, Yi-Shuo Dong, Zhong-Hua Yang, Yi-Lei Li, Si-Wen Yi, Qiao-Yan Wang, Peng Shi, Yin-Ping Zhang, Ying-Ying Shi, Hai-Yan
Published in
Scientific reports
To establish a population pharmacokinetic (PopPK) model of posaconazole suspension in Chinese hematopoietic stem cell transplantation (HSCT) patients and to recommend an optimal dosing regimen. A single-center, retrospective, model-based study was conducted in 62 Chinese patients, including 103 with posaconazole plasma concentrations. PopPK analysi...
Mariottini, Alice Nozzoli, Chiara Carli, Ilaria Landi, Filippo Gigli, Valentina Repice, Anna Maria Ipponi, Alessandra Cecchi, Michele Boncompagni, Riccardo Saccardi, Riccardo
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Published in
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Autologous haematopoietic stem cell transplantation (AHSCT) is a highly effective one-off treatment for relapsing-remitting multiple sclerosis (RR-MS), potentially representing an optimal front-loading strategy for costs. Exploring cost/effectiveness of AHSCT and high-efficacy disease-modifying treatments (HE-DMTs) in RR-MS, estimating costs at our...
De Greef, Julien; Averbuch, Dina; Tondeur, Laura; Dureault, Amelie; Zuckerman, Tsila; Roussel, Xavier; Robin, Christine; Xhaard, Alienor; Pagliuca, Simona; Beguin, Yves;
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OBJECTIVES: Nocardiosis is a rare but life-threatening infection after hematopoietic cell transplantation (HCT). We aimed at identifying risk factors for nocardiosis after allogeneic HCT and clarifying the effect of trimethoprim-sulfamethoxazole prophylaxis on its occurrence. METHODS: We performed a retrospective multicenter case-control study of p...
De Greef, Julien Averbuch, Dina Tondeur, Laura Duréault, Amélie Zuckerman, Tsila Roussel, Xavier Robin, Christine Xhaard, Alienor Pagliuca, Simona Beguin, Yves
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Published in
The Journal of infection
Nocardiosis is a rare but life-threatening infection after hematopoietic cell transplantation (HCT). We aimed at identifying risk factors for nocardiosis after allogeneic HCT and clarifying the effect of trimethoprim-sulfamethoxazole prophylaxis on its occurrence. We performed a retrospective multicenter case-control study of patients diagnosed wit...
Iwamuro, Masaya Ennishi, Daisuke Fujii, Nobuharu Matsuoka, Ken-Ichi Tanaka, Takehiro Inokuchi, Toshihiro Hiraoka, Sakiko Otsuka, Motoyuki
Background Endoscopic features of intestinal transplant-associated microangiopathy (iTAM) have not been comprehensively investigated. This study aimed to examine the endoscopic characteristics of patients diagnosed with iTAM.
Methods This retrospective analysis included 14 patients pathologically diagnosed with iTAM after stem cell transplantation ...
Iwamuro, Masaya Ennishi, Daisuke Fujii, Nobuharu Matsuoka, Ken-Ichi Tanaka, Takehiro Inokuchi, Toshihiro Hiraoka, Sakiko Otsuka, Motoyuki
Published in
BMC gastroenterology
Endoscopic features of intestinal transplant-associated microangiopathy (iTAM) have not been comprehensively investigated. This study aimed to examine the endoscopic characteristics of patients diagnosed with iTAM. This retrospective analysis included 14 patients pathologically diagnosed with iTAM after stem cell transplantation for hematolymphoid ...
Peereboom, Emma T.M. Maranus, Anna E. Timmerman, Laura M. Geneugelijk, Kirsten Spierings, Eric
Published in
Transfusion Medicine and Hemotherapy
Introduction: Human leukocyte antigen (HLA)-DPB1 mismatches during hematopoietic stem cell transplantation (HSCT) with an unrelated donor result in an increased risk for the development of graft-versus-host disease (GvHD). The number of CD8+ T-cell epitopes available for indirect allorecognition as predicted by the PIRCHE algorithm has been shown t...
Li, Ziye Wang, Yongqi Li, Gangping Ma, Nan Li, Minghui Yuan, Fangfang Fu, Yuewen Wang, Li
Published in
Biotechnology & genetic engineering reviews
Graft-versus-host disease (GVHD) is caused by a pathologic and destructive response of the organism as a result of the interaction between donor immunocompetent T lymphocytes and the recipient tisular antigens1. Graft-versus-host disease is considered a serious complication of hematopoietic stem cell transplantation. The skin, oral cavity and lungs...
