Candelas, Adrian Vianay, Benoit Gelin, Matthieu Faivre, Lionel Larghero, Jerome Blanchoin, Laurent Théry, Manuel Brunet, Stéphane
ABSTRACT Hematopoietic stem and progenitor cells (HSPCs) give rise to all cell types of the hematopoietic system through various processes, including asymmetric divisions. However, the contribution of stromal cells of the hematopoietic niches in the control of HSPC asymmetric divisions remains unknown. Using polyacrylamide microwells as minimalist ...
Dahariya, Swati Enright, Anton Kumar, Santosh Gutti, Ravi Kumar
Peer reviewed: True / Acknowledgements: The authors thank the DBT (India), the British Council, and the University of Cambridge for the Newton-Bhabha Student Exchange Program (2019–2020). The authors thank the University of Hyderabad (School of Life Sciences) and the University of Cambridge (Department of Pathology) for providing the laboratory and...
Brunetti, Mia Iasenza, Isabella A. Jenner, Adrianne L. Raynal, Noël J.M. Eppert, Kolja Craig, Morgan
Over the years, the overall survival of older patients diagnosed with acute myeloid leukemia (AML) has not significantly increased. Although standard cytotoxic therapies that rapidly eliminate dividing myeloblasts are used to induce remission, relapse can occur due to surviving therapy-resistant leukemic stem cells (LSCs). Hence, anti-LSC strategie...
Fowler, Jonas L Zheng, Sherry Li Nguyen, Alana Chen, Angela Xiong, Xiaochen Chai, Timothy Chen, Julie Y Karigane, Daiki Banuelos, Allison M Niizuma, Kouta
...
The developmental origin of blood-forming hematopoietic stem cells (HSCs) is a longstanding question. Here, our non-invasive genetic lineage tracing in mouse embryos pinpoints that artery endothelial cells generate HSCs. Arteries are transiently competent to generate HSCs for 2.5 days (∼E8.5-E11) but subsequently cease, delimiting a narrow time fra...
Brunetti, Mia Iasenza, Isabella A Jenner, Adrianne L Raynal, Noël J-M Eppert, Kolja Craig, Morgan
Published in
Leukemia research
Over the years, the overall survival of older patients diagnosed with acute myeloid leukemia (AML) has not significantly increased. Although standard cytotoxic therapies that rapidly eliminate dividing myeloblasts are used to induce remission, relapse can occur due to surviving therapy-resistant leukemic stem cells (LSCs). Hence, anti-LSC strategie...
Pv, Anu; Mehatre, Shubham Haribhau; Verfaillie, Catherine M.; 48658; Alam, Mohammad Tauqeer; Khurana, Satish;
The first definitive hematopoietic progenitors emerge through the process of endothelial-to-hematopoietic transition in vertebrate embryos. With molecular regulators for this process worked out, the role of metabolic pathways used remains unclear. Here, we performed nano-LC-MS/MS-based proteomic analysis and predicted a metabolic switch from a glyc...
Pv, Anu; Mehatre, Shubham Haribhau; Verfaillie, Catherine M.; 48658; Alam, Mohammad Tauqeer; Khurana, Satish;
The first definitive hematopoietic progenitors emerge through the process of endothelial-to-hematopoietic transition in vertebrate embryos. With molecular regulators for this process worked out, the role of metabolic pathways used remains unclear. Here, we performed nano-LC-MS/MS-based proteomic analysis and predicted a metabolic switch from a glyc...
Pv, Anu; Mehatre, Shubham Haribhau; Verfaillie, Catherine M.; 48658; Alam, Mohammad Tauqeer; Khurana, Satish;
The first definitive hematopoietic progenitors emerge through the process of endothelial-to-hematopoietic transition in vertebrate embryos. With molecular regulators for this process worked out, the role of metabolic pathways used remains unclear. Here, we performed nano-LC-MS/MS-based proteomic analysis and predicted a metabolic switch from a glyc...
Pardo-Cea, Miguel Angel Farré, Xavier Esteve, Anna Palade, Joanna Espín, Roderic Mateo, Francesca Alsop, Eric Alorda, Marc Blay, Natalia Baiges, Alexandra
...
Published in
Genome medicine
The immune system has a central role in preventing carcinogenesis. Alteration of systemic immune cell levels may increase cancer risk. However, the extent to which common genetic variation influences blood traits and cancer risk remains largely undetermined. Here, we identify pleiotropic variants and predict their underlying molecular and cellular ...
Soum, Cécile
Les leucémies aiguës myéloïdes (LAM) sont des hémopathies malignes caractérisées par une dérégulation de l'hématopoïèse. Les altérations (translocations chromosomiques et/ou mutations) conduisent à un blocage de la différenciation cellulaire, une prolifération clonale accrue et une accumulation de blastes myéloïdes dans la moelle osseuse et le sang...