Tothova, Zuzana Valton, Anne-Laure Venev, Sergey V. Dekker, Job Ebert, Benjamin L.
The cohesin complex plays an essential role in chromosome maintenance and transcriptional regulation. Recurrent somatic mutations in the cohesin complex are frequent genetic drivers in cancer, including myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). Here, using genetic dependency screens of stromal antigen 2-mutant (STAG2-mutant)...
Singh, Suvir Singh, Jagdeep Paul, Davinder Jain, Kunal
Published in
Clinical Lymphoma, Myeloma & Leukemia
The Coronavirus disease-2019 (COVID-19) pandemic is an unprecedented health care crisis and has led to over 1.5 million deaths worldwide. The risk of severe COVID-19 and mortality is markedly raised in patients with cancer, prompting several collaborative groups to issue guidelines to mitigate the risk of infection by delaying or de-escalating immu...
Susheela, Ammu Thampi Vadakapet, Padmesh Pillai, Lekshmi Thampi, Susheela
Published in
Journal of Medical Case Reports
BackgroundFamilial chylomicronemia is an extremely rare disease. Lipoprotein lipase deficiency, lipoprotein defect or lipoprotein receptor defect are the main genetic causes of familial chylomicronemia.Case presentationWe report a rare case of hypertriglyceridemia which was diagnosed at 24 days after birth. A newborn south east Asian baby born for ...
Harrysson, Sara Eloranta, Sandra Ekberg, Sara Enblad, Gunilla Jerkeman, Mats Wahlin, Bjorn E. Andersson, Per-Ola Smedby, Karin E.
Published in
Blood Cancer Journal
We performed a national population-based study of all patients diagnosed with diffuse large B-cell lymphoma (DLBCL) in Sweden in 2007–2014 to assess treatment intent and risk of relapsed/refractory disease, including central nervous system (CNS) relapse, in the presence of competing risks. Overall, 84% of patients started treatment with curative in...
Romeo, Claudia D’Alessandro, Sara Bielli, Mattia Comazzi, Stefano Ferrari, Nicola
Published in
European Journal of Wildlife Research
The eastern grey squirrel (Sciurus carolinensis) is a North American tree squirrel species which has been introduced to several countries outside its native range. We made use of squirrels culled in Italy within control activities to establish hematological reference intervals for this invasive species, with the aim to broaden the current knowledge...
Chan, Raymond Javan Buhagiar, Stephanie Teleni, Laisa Simonsen, Camilla Turner, Jane Rawson, Courtney Hart, Nicolas H. Jones, Lee Gordon, Louisa Joseph, Ria
...
Published in
Trials
BackgroundSurvival rates for lymphoma are highest amongst hematological malignancies. In 2019, it was estimated that over 6400 Australians were diagnosed with lymphoma, a group of hematological malignancies with a high 5-year survival rate of ~ 76%. There is an increased focus on the promotion of wellness in survivorship and active approaches to re...
Almotiri, Alhomidi Alzahrani, Hamed Ahmad A Menendez-Gonzalez, Juan Bautista Abdelfattah, Ali Alotaibi, Badi Saleh, Lubaid Greene, Adelle Georgiou, Mia R F Gibbs, Alex Alsayari, Amani Salem
...
Published in
The Journal of clinical investigation
Zeb1, a zinc finger E-box binding homeobox epithelial-mesenchymal (EMT) transcription factor, confers properties of 'stemness', such as self-renewal, in cancer. Yet little is known about the function of Zeb1 in adult stem cells. Here, we used the hematopoietic system, as a well-established paradigm of stem cell biology, to evaluate Zeb1 mediated re...
Akintimehin, Emmanuel Sina Karigidi, Kayode Olayele Omogunwa, Tope Samuel Adetuyi, Foluso Olutope
Published in
Clinical Phytoscience
BackgroundConsumption of medicinal plants has diverse therapeutic benefits and could also have toxic effect. Justicia carnea is a medicinal plant that is used conventionally as blood tonic from time immemorial in Nigeria. The aim of this study is to evaluate the safety of ethanol extract of J. carnea leaf assessing the hematology indices, organ ant...
De Decker, Matthias Lavaert, Marieke Roels, Juliette Tilleman, Laurentijn Vandekerckhove, Bart Leclercq, Georges Van Nieuwerburgh, Filip Van Vlierberghe, Pieter Taghon, Tom
Published in
Haematologica
In both mouse and human, Notch1 activation is the main initial driver to induce T-cell development in hematopoietic progenitor cells. The initiation of this developmental process coincides with Notch1-dependent repression of differentiation towards other hematopoietic lineages. Although well described in mice, the role of the individual Notch1 targ...
alzahrani, faisal m. al-amri, ali shaikh, saeed sattar alomar, amer ibrahim acharya, sadananda aldossary, maryam ahmed hassan, fathelrahman mahdi
Introduction. Bloodstream infections (BSI) among patients with hematological malignancies (HM) could predispose them to higher morbidity and mortality for various underlying conditions. Several microorganisms, either pathogenic or opportunistic normal human flora, could cause severe bacteremia and septicemia. While conventional methods have their o...