Published in Fish physiology and biochemistry
The objective of the present study was to evaluate the physiological responses of juvenile Lophiosilurus alexandri submitted to osmotic and thermic shock. Thirty juveniles were used for each test, of which 10 were not subjected to stress and remained in normal conditions (fresh water at 28.0 °C). The others were submitted to stress shock (saline wa...
Background:Evasion from programmed cell death is a hallmark of cancer and can be achieved in cancer cells by overexpression of inhibitor of apoptosis proteins (IAPs). Second mitochondria-derived activator of caspases (SMAC) directly bind to IAPs and promote apoptosis; thus, SMAC mimetics have been investigated in a variety of cancer types. particul...
Published in Tropical animal health and production
Tropical and subtropical regions were quite short of high-quality protein forage. Ramie (Boehmeria nivea L. Gaud) leaves as crop by products, are rich in protein and widely cultivated in tropical and subtropical regions. Thence, the development and utilization of ramie is of great significance to animal production in these regions. But it contained...
BACKGROUND:Bridging heart failure patients with mechanical ventricular assist devices (VAD) enables access to transplantation. However, VAD is associated with increased risk for anti-HLA antibodies associated with rejection of subsequent allografts. Factors determining alloantibody formation in these patients remain undefined. METHODS:We performed ...
Acute lymphoblastic leukemia (ALL), a common child malignancy, also constitutes a minor fraction of adult cancer with approximately 50 new cases per year in Sweden. While the five-year overall survival (OS) in pediatric ALL is more than 90%, the prognosis in adults is dismal. Using the Swedish ALL quality registry, this thesis investigates treatmen...
A study of myelostimulating activity of ionic compounds-trimecaine alkyl iodide derivatives under the cipher BIV (BIV-117, BIV-118, and BIV-119) was conducted on a model of doxorubicin pancytopenia in white laboratory rats. It was established that the compounds BIV-117 and BIV-119 had a pronounced leukopoiesis-stimulating activity, exceeding the ac...
Published in Clinical Phytoscience
BackgroundJusticia secunda Vahl. is a medicinal plant used in ethnomedical practice as therapy to manage inflammation. Therefore, this study was designed to evaluate the anti-inflammatory activity of methanol extract of J. secunda leaves (MEJSL) using in vitro and in vivo inflammation models.MethodsSeventy-percent MEJSL was prepared following stand...
Published in Critical Care
BACKGROUND: Hemophilia A, a bleeding disorder resulting from F8 mutations, can only be cured by gene therapy. A promising strategy is CRISPR-Cas9-mediated precise insertion of F8 in hepatocytes at highly expressed gene loci, such as albumin (Alb). Unfortunately, the precise in vivo integration efficiency of a long insert is very low (~ 0.1%). RESUL...
Resumo: O objetivo deste estudo foi avaliar as variáveis hematológicas de tilápias para obtenção de potenciais biomarcadores de peixes no monitoramento de qualidade da água dos sistemas de aquários experimentais. Avaliou-se as alterações na série vermelha em juvenis de tilápias mantidas durante 30 dias em sistema de aquários com volume útil de 300 ...
