Mbayabo, Gloire Ngole, Mamy Lumbala, Paul Kabuyi Lumaka Zola, Aimé Race, Valerie Matthijs, Gert Mikobi, Tite Minga Devriendt, Koenraad Van Geet, Chris Lukusa, Prosper Tshilobo
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peer reviewed / [en] BACKGROUND: Sickle Cell Anemia (SCA) is the most common genetic disease worldwide caused by a single mutation in the gene HBB. The disease severity is very variable and depends on many factors. We evaluated the clinical and biological profile of sickle cell anemia children in rural Central Africa. METHODS: This cross-sectional ...
Ge, Guo Zhang, Peng Sui, Pinpin Chen, Shi Yang, Hui Guo, Ying Rubalcava, Ivan P Noor, Asra Delma, Caroline R Agosto-Peña, Joel
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Published in
The Journal of clinical investigation
ASXL1 mutation frequently occurs in all forms of myeloid malignancies and is associated with aggressive disease and poor prognosis. ASXL1 recruits Polycomb Repressive Complex 2 (PRC2) to specific gene loci to repress transcription through tri-methylation of histone H3 on lysine 27 (H3K27me3). ASXL1 alterations reduce H3K27me3 levels, which results ...
Ruutu, Tapani; Peczynski, Christophe; Houhou, Mohamed; Polge, Emmanuelle; Mohty, Mohamad; Kroeger, Nicolaus; Moiseev, Ivan; Penack, Olaf; Salooja, Nina; Schoemans, Helene; 50822;
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The current incidence, diagnostic policy, management, and outcome of VOD/SOS at EBMT centers were studied. All centers that had performed allogeneic HSCTs in adult patients within one defined year were invited to the study. Seventy-one centers participated with a total of 2886 allogeneic transplantations and 93 cases of VOD/SOS in 2018. The cumulat...
Hoechsmann, Britta; de Latour, Regis Peffault; Hill, Anita; Roeth, Alexander; Devos, Timothy; 38533; Patriquin, Christopher J; Chou, Wen-Chien; Jain, Deepak; Zu, Ke; Wu, Chuntao;
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The objective of this analysis was to identify risk factors for thromboembolic events (TE) in patients with paroxysmal nocturnal hemoglobinuria (PNH) who were not treated with C5 inhibitors. Patients with PNH and a history of ≥ 1 TE at enrollment in the International PNH Registry (NCT01374360; registration date, January 2011) were each matched with...
Jahn, Ekaterina; Saadati, Maral; Fenaux, Pierre; Gobbi, Marco; Roboz, Gail J; Bullinger, Lars; Lutsik, Pavlo; 153916; Riedel, Anna; Plass, Christoph; Jahn, Nikolaus;
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To characterize the genomic landscape and leukemogenic pathways of older, newly diagnosed, non-intensively treated patients with AML and to study the clinical implications, comprehensive genetics analyses were performed including targeted DNA sequencing of 263 genes in 604 patients treated in a prospective Phase III clinical trial. Leukemic traject...
Munung, Nchangwi Syntia Treadwell, Marsha Kamga, Karen Kengne Dennis-Antwi, Jemima Anie, Kofi Bukini, Daima Makani, Julie Wonkam, Ambroise
PurposeSickle cell disease (SCD) is an inherited blood disorder characterized by unpredictable episodes of acute pain and numerous health complications. Individuals with SCD often face stigma from the public, including perceptions that they are lazy or weak tending to exaggerate their pain crisis, which can profoundly impact their quality of life (...
Meyers, Sarah Demeyer, Sofie Cools, Jan
Published in
Journal of hematology & oncology
The CRISPR genome editing technology has revolutionized the way gene function is studied. Genome editing can be achieved in single genes or for thousands of genes simultaneously in sensitive genetic screens. While conventional genetic screens are limited to bulk measurements of cell behavior, recent developments in single-cell technologies make it ...
Meyers, Sarah; 132329; Demeyer, Sofie; 97449; Cools, Jan; 16417;
The CRISPR genome editing technology has revolutionized the way gene function is studied. Genome editing can be achieved in single genes or for thousands of genes simultaneously in sensitive genetic screens. While conventional genetic screens are limited to bulk measurements of cell behavior, recent developments in single-cell technologies make it ...
Kolijn, P Martijn Späth, Florentin Khouja, Mouhamad Hengeveld, Paul J van der Straten, Lina Darzentas, Nikos Hultdin, Magnus McKay, James D Pott, Christiane Vermeulen, Roel C H
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Published in
Blood
Schroyens, Natalie; 98433; D'aes, Tine; De Buck, Emmy; 40859; Mikkelsen, Susan; Tiberghien, Pierre; van den Hurk, Katja; Erikstrup, Christian; Compernolle, Veerle; Van Remoortel, Hans;
BACKGROUND AND OBJECTIVES: As part of a large-scale project to safely increase plasma collection in Europe, the current scoping review identifies the existing evidence (gaps) on adverse events (AEs) and other health effects in plasmapheresis donors, as well as factors that may be associated with such events/effects. MATERIALS AND METHODS: We search...